Suppression of laser-induced choroidal neovascularization
... The choroidal neovascular membrane then destroys the macula, which results in visual loss. Although submacular surgery to remove CNV has been advocated, the efficacy of this new therapy has yet to be convincingly demonstrated,8"11 and at present laser photocoagulation is the only well-established tr ...
... The choroidal neovascular membrane then destroys the macula, which results in visual loss. Although submacular surgery to remove CNV has been advocated, the efficacy of this new therapy has yet to be convincingly demonstrated,8"11 and at present laser photocoagulation is the only well-established tr ...
annex iv: biowaiver request for additional strengths
... and evaluation of bioequivalence studies for immediate release and modified release dosage forms with systemic action. Two medicinal products containing the same active substance are considered bioequivalent if they are pharmaceutically equivalent or Pharmaceutical alternatives and their bioavailabi ...
... and evaluation of bioequivalence studies for immediate release and modified release dosage forms with systemic action. Two medicinal products containing the same active substance are considered bioequivalent if they are pharmaceutically equivalent or Pharmaceutical alternatives and their bioavailabi ...
Methadone—metabolism, pharmacokinetics and interactions
... due to the frequent comorbidity of drug addicts: psychotropic drugs, antibiotics, anticonvulsants and antiretroviral drugs, which can cause pharmacokinetic interactions. In particular, antiretrovirals, which are CYP3A4 inducers, can decrease the levels of methadone, so causing withdrawal symptoms. B ...
... due to the frequent comorbidity of drug addicts: psychotropic drugs, antibiotics, anticonvulsants and antiretroviral drugs, which can cause pharmacokinetic interactions. In particular, antiretrovirals, which are CYP3A4 inducers, can decrease the levels of methadone, so causing withdrawal symptoms. B ...
Retrospective Review of Trend in Modafinil Overexposures
... Due to the off-label use for cognitive enhancement in psychiatric disorders such as schizophrenia and ADHD, modafinil and other stimulant medications have been sought by healthy individuals in order to improve cognitive function (14-16). Modafinil has been shown to improve neuropsychological perform ...
... Due to the off-label use for cognitive enhancement in psychiatric disorders such as schizophrenia and ADHD, modafinil and other stimulant medications have been sought by healthy individuals in order to improve cognitive function (14-16). Modafinil has been shown to improve neuropsychological perform ...
important safety information ˆ dosing calendar | every 28 days
... Palivizumab may interfere with immunological-based RSV diagnostic tests such as some antigen detection-based assays. In addition, palivizumab inhibits virus replication in cell culture, and therefore may also interfere with viral culture assays. Palivizumab does not interfere with reverse transcript ...
... Palivizumab may interfere with immunological-based RSV diagnostic tests such as some antigen detection-based assays. In addition, palivizumab inhibits virus replication in cell culture, and therefore may also interfere with viral culture assays. Palivizumab does not interfere with reverse transcript ...
11 The Use of Melatonin in Children with Sleep Disturbances
... therapy. Because melatonin may also play a role in immune function, it is not recommended for patients with autoimmune disorders.2 Dosing Based on the case series and clinical trials published to date, melatonin should be initiated at a dose of 2.5 to 5 mg in children with sleep disturbances. The do ...
... therapy. Because melatonin may also play a role in immune function, it is not recommended for patients with autoimmune disorders.2 Dosing Based on the case series and clinical trials published to date, melatonin should be initiated at a dose of 2.5 to 5 mg in children with sleep disturbances. The do ...
formulation and evaluation of ibuprofen suppositories
... many researchers. The advantages of this route over other routs of administration include avoiding the first pass metabolism and minimizing gastric irritation. The rectum has a good blood supply, absence of villi and a relatively small surface area (0.020.05 m2). Rectum also contains a small volume ...
... many researchers. The advantages of this route over other routs of administration include avoiding the first pass metabolism and minimizing gastric irritation. The rectum has a good blood supply, absence of villi and a relatively small surface area (0.020.05 m2). Rectum also contains a small volume ...
English Sapphire Rev13 Drug Library Editor User Manual
... dose and hard/soft limits. The software accommodates up to 40 CCAs and up to 8,500 unique medication rule sets. Each CCA can accommodate up to 1,000 medication rule sets, and each unique medication rule set can be assigned to more than one CCA, i.e., up to a total of 40,000 medications. The software ...
... dose and hard/soft limits. The software accommodates up to 40 CCAs and up to 8,500 unique medication rule sets. Each CCA can accommodate up to 1,000 medication rule sets, and each unique medication rule set can be assigned to more than one CCA, i.e., up to a total of 40,000 medications. The software ...
Important Drug Information
... To place an order, or if you have any questions, customers can contact Hospira directly by calling Customer Care at 1-877-946-7747 (Monday – Friday, 7AM-6PM CDT). Hospira will make reasonable attempts to fill your orders. Hospira will be closely monitoring the distribution of Doxorubicin Hydrochlori ...
... To place an order, or if you have any questions, customers can contact Hospira directly by calling Customer Care at 1-877-946-7747 (Monday – Friday, 7AM-6PM CDT). Hospira will make reasonable attempts to fill your orders. Hospira will be closely monitoring the distribution of Doxorubicin Hydrochlori ...
product monograph
... complicated by the possibility of an increased background risk of diabetes mellitus in patients with schizophrenia and the increasing incidence of diabetes mellitus in the general population. Given these confounders, the relationship between atypical antipsychotic use and hyperglycemia-related adver ...
... complicated by the possibility of an increased background risk of diabetes mellitus in patients with schizophrenia and the increasing incidence of diabetes mellitus in the general population. Given these confounders, the relationship between atypical antipsychotic use and hyperglycemia-related adver ...
Single Exposure of Human Oral Mucosa Fibroblasts to
... The lip vermillion constitutes a transition tissue, between oral mucosa and skin, where oral mucosal cells from epithelial and connective tissue compartments are exposed to ultraviolet (UV) sunlight. Fibroblasts are abundant resident cells of the connective tissue which are key regulators of extrace ...
... The lip vermillion constitutes a transition tissue, between oral mucosa and skin, where oral mucosal cells from epithelial and connective tissue compartments are exposed to ultraviolet (UV) sunlight. Fibroblasts are abundant resident cells of the connective tissue which are key regulators of extrace ...
Efficacy of Lidocaine Iontophoresis Using Either Alternating or Direct
... tendencies in lidocaine concentration. In the DCIOP group, lidocaine concentration reached its maximum 20 min after current application and then decreased rapidly; the AC-IOP group showed an increase in lidocaine concentration in a timedependent manner. There were no side effects such as electrical ...
... tendencies in lidocaine concentration. In the DCIOP group, lidocaine concentration reached its maximum 20 min after current application and then decreased rapidly; the AC-IOP group showed an increase in lidocaine concentration in a timedependent manner. There were no side effects such as electrical ...
DP-Anastrozole
... recurrence-free survival especially in patients with receptor positive status. Administration of anastrozole also significantly reduced the incidence of contralateral breast cancer and time to distant recurrence was also numerically superior. There was no efficacy benefit seen when anastrozole was a ...
... recurrence-free survival especially in patients with receptor positive status. Administration of anastrozole also significantly reduced the incidence of contralateral breast cancer and time to distant recurrence was also numerically superior. There was no efficacy benefit seen when anastrozole was a ...
Levitra
... By inhibiting PDE5, the enzyme responsible for cGMP degradation in the corpus cavernosum, vardenafil potently enhances the effect of endogenous NO, locally released in corpus cavernosum upon sexual stimulation. The inhibition of PDE5 by vardenafil leads to increased cGMP levels in the corpus caverno ...
... By inhibiting PDE5, the enzyme responsible for cGMP degradation in the corpus cavernosum, vardenafil potently enhances the effect of endogenous NO, locally released in corpus cavernosum upon sexual stimulation. The inhibition of PDE5 by vardenafil leads to increased cGMP levels in the corpus caverno ...
Artemisia annua (Asteraceae) Description of the plant Plant parts
... Activity on immune responses Artemisinin, dihydroartemisinin and arteether in doses of 400 and 600 mg/kg body weight suppressed humoral responses of sheep, as measured by the hemolytic plaque assay. Arteether was the most effective drug. When tested on carrageenan-induced edema all three agents did ...
... Activity on immune responses Artemisinin, dihydroartemisinin and arteether in doses of 400 and 600 mg/kg body weight suppressed humoral responses of sheep, as measured by the hemolytic plaque assay. Arteether was the most effective drug. When tested on carrageenan-induced edema all three agents did ...
ALFENTANIL 500 MICROGRAMS / ML SOLUTION FOR INJECTION
... Lower or less frequent dosing may be required owing to a longer half-life of alfentanil in this age group (dilution may be helpful). In spontaneously breathing patients, the initial bolus dose should be given slowly over about 30 seconds (dilution may be helpful). After intravenous administration in ...
... Lower or less frequent dosing may be required owing to a longer half-life of alfentanil in this age group (dilution may be helpful). In spontaneously breathing patients, the initial bolus dose should be given slowly over about 30 seconds (dilution may be helpful). After intravenous administration in ...
Medication Guide
... CONCERTA® is indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children 6 years of age and older, adolescents, and adults up to the age of 65 [see Clinical Studies (14)]. A diagnosis of Attention Deficit Hyperactivity Disorder (ADHD; DSM-IV) implies the presence of hy ...
... CONCERTA® is indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children 6 years of age and older, adolescents, and adults up to the age of 65 [see Clinical Studies (14)]. A diagnosis of Attention Deficit Hyperactivity Disorder (ADHD; DSM-IV) implies the presence of hy ...
Zeldox capsule, hard ENG SmPC
... controlled clinical trials, the combination of ziprasidone plus lithium has not demonstrated an increased clinical risk, compared to lithium alone. There are limited data on co-medication with the mood stabiliser carbamazepine . A pharmacokinetic interaction of ziprasidone with valproate is unlikely ...
... controlled clinical trials, the combination of ziprasidone plus lithium has not demonstrated an increased clinical risk, compared to lithium alone. There are limited data on co-medication with the mood stabiliser carbamazepine . A pharmacokinetic interaction of ziprasidone with valproate is unlikely ...
Extract from Clinical Evaluation Report: Ruxolitinib
... The submission did not include paediatric data. This not considered a deficiency given that MF is unlikely to occur in children and adolescents. ...
... The submission did not include paediatric data. This not considered a deficiency given that MF is unlikely to occur in children and adolescents. ...
cytochrome p-450 3a4 and 2c8 are involved in zopiclone metabolism
... involved in zopiclone metabolism have not yet been identified (Noble et al., 1998), but cytochrome P-450 (CYP) isoforms may be suspected because some drug interactions in humans with CYP inhibitors or inducers have been reported (Aranko et al., 1994; Jalava et al., 1996; Villikka et al., 1997). Beca ...
... involved in zopiclone metabolism have not yet been identified (Noble et al., 1998), but cytochrome P-450 (CYP) isoforms may be suspected because some drug interactions in humans with CYP inhibitors or inducers have been reported (Aranko et al., 1994; Jalava et al., 1996; Villikka et al., 1997). Beca ...
DIPYRIDAMOLE TABLETS USP 25 MG, 50 MG AND 75 MG
... pregnant women. Because animal reproduction studies are not always predictive of human response, ...
... pregnant women. Because animal reproduction studies are not always predictive of human response, ...
8 Ultra-low-dose opioid antagonists enhance opioid analgesia while
... analgesic therapy may or may not develop analgesic tolerance, they usually become physically dependent, requiring careful tapering off of the opiate in order to minimize withdrawal effects (Heit, 2003; Woolf and Hashmi, 2004). While the incidence of actual addiction or even misuse of prescription op ...
... analgesic therapy may or may not develop analgesic tolerance, they usually become physically dependent, requiring careful tapering off of the opiate in order to minimize withdrawal effects (Heit, 2003; Woolf and Hashmi, 2004). While the incidence of actual addiction or even misuse of prescription op ...
Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers
... device and therefore requires an incision for introduction into the vitreous cavity, as well as a secondary surgical intervention for device removal following exhaustion of the drug reservoir. The I-vation (Surmodics) drug delivery system is another example of a non-degrading, sustained intravitreal ...
... device and therefore requires an incision for introduction into the vitreous cavity, as well as a secondary surgical intervention for device removal following exhaustion of the drug reservoir. The I-vation (Surmodics) drug delivery system is another example of a non-degrading, sustained intravitreal ...
Opioids analgesics and antagonists
... • change in the methyl group on 3 position of morphine (substituted for the hydroxyl group) • one tenth the potency (analgesic properties) of morphine • absorbed readily from GI tract • the absorption is more regular than morphine and more predictable • given orally • metabolized like morphine throu ...
... • change in the methyl group on 3 position of morphine (substituted for the hydroxyl group) • one tenth the potency (analgesic properties) of morphine • absorbed readily from GI tract • the absorption is more regular than morphine and more predictable • given orally • metabolized like morphine throu ...
RISK PROFILE of acetanilide
... Acetanilide is no longer used as a drug in its own right, but the success of its metabolite – paracetamol (acetaminophen) – is well known as a safer alternative (9). Thus, the following observations might be relevant for total exposure assessments. Using painkillers such as ibuprofen, aspirin and pa ...
... Acetanilide is no longer used as a drug in its own right, but the success of its metabolite – paracetamol (acetaminophen) – is well known as a safer alternative (9). Thus, the following observations might be relevant for total exposure assessments. Using painkillers such as ibuprofen, aspirin and pa ...