dbl™ cytarabine injection
... to the cytotoxic effects of cytarabine. Tissues with a high susceptibility have high levels of the activating enzyme. Cytarabine’s actions are cell-cycle specific as it has no effect on non-proliferating cells, or on proliferating cells unless in the S or DNA synthesis phase. Cytarabine is also immu ...
... to the cytotoxic effects of cytarabine. Tissues with a high susceptibility have high levels of the activating enzyme. Cytarabine’s actions are cell-cycle specific as it has no effect on non-proliferating cells, or on proliferating cells unless in the S or DNA synthesis phase. Cytarabine is also immu ...
rna interference for improving the outcome of islet
... expressions at the mRNA level. The application of RNA interference to improve the outcome of islet transplantation was reviewed in Chapter 2, where I summarized biological obstacles to islet transplantation, various types of RNAi techniques, combinatorial RNAi in islet transplantation, and different ...
... expressions at the mRNA level. The application of RNA interference to improve the outcome of islet transplantation was reviewed in Chapter 2, where I summarized biological obstacles to islet transplantation, various types of RNAi techniques, combinatorial RNAi in islet transplantation, and different ...
FLOVENT HFA (fluticasone propionate) Inhalation Aerosol
... fatal course in susceptible children or adults using corticosteroids. In such children or adults who have not had these diseases or been properly immunized, particular care should be taken to avoid exposure. How the dose, route, and duration of corticosteroid administration affect the risk of develo ...
... fatal course in susceptible children or adults using corticosteroids. In such children or adults who have not had these diseases or been properly immunized, particular care should be taken to avoid exposure. How the dose, route, and duration of corticosteroid administration affect the risk of develo ...
Review of application by Expert Committee Member
... years. Ibuprofen and paracetamol produced significant antipyresis when both are compared to placebo, no adverse effect were observed in any treated group 6. The authors concluded that ibuprofen is a potent antipyretic agent for a selected febrile child who can neither take nor achieve satisfactory a ...
... years. Ibuprofen and paracetamol produced significant antipyresis when both are compared to placebo, no adverse effect were observed in any treated group 6. The authors concluded that ibuprofen is a potent antipyretic agent for a selected febrile child who can neither take nor achieve satisfactory a ...
Morphine Glucuronidation and Glucosidation Represent
... UDP-Glc as cofactor to form glucoside conjugates (Senafi et al., 1994; Mackenzie et al., 2003; Tang et al., 2003; Toide et al., 2004; Obach et al., 2006; Buchheit et al., 2011). In contrast, UGT3A1 and UGT3A2 use sugar donors other than UDP-GlcUA (Mackenzie et al., 2008, 2011). Notably, UGT3A2 gluco ...
... UDP-Glc as cofactor to form glucoside conjugates (Senafi et al., 1994; Mackenzie et al., 2003; Tang et al., 2003; Toide et al., 2004; Obach et al., 2006; Buchheit et al., 2011). In contrast, UGT3A1 and UGT3A2 use sugar donors other than UDP-GlcUA (Mackenzie et al., 2008, 2011). Notably, UGT3A2 gluco ...
Full Text - European Heart Journal Supplements
... measurements of BP; some placebo patients experienced increases in BP of 25, 35, or even 40 mmHg. It is well known that BP can randomly fluctuate up or down in any given patient on a given day; clinicians expect to see this spontaneous change in BP. With sibutramine, there was no statistically signifi ...
... measurements of BP; some placebo patients experienced increases in BP of 25, 35, or even 40 mmHg. It is well known that BP can randomly fluctuate up or down in any given patient on a given day; clinicians expect to see this spontaneous change in BP. With sibutramine, there was no statistically signifi ...
diltiazem hydrochloride injection
... In patients with atrial fibrillation and atrial flutter, a significant correlation was observed between the percent reduction in HR and plasma diltiazem concentration using the Sigmoidal Emax model. Based on this relationship, the mean plasma diltiazem concentration required to produce a 20% decreas ...
... In patients with atrial fibrillation and atrial flutter, a significant correlation was observed between the percent reduction in HR and plasma diltiazem concentration using the Sigmoidal Emax model. Based on this relationship, the mean plasma diltiazem concentration required to produce a 20% decreas ...
Anosmia after Intranasal Zinc Gluconate Use
... protection could only be gained by erecting an impenetrable barrier around the olfactory nerves. The success of the treatment would be judged by making the nerves “inactive for a period of time,” the criterion for success being “loss of the sense of smell.”14 “Protection against the virus” could not ...
... protection could only be gained by erecting an impenetrable barrier around the olfactory nerves. The success of the treatment would be judged by making the nerves “inactive for a period of time,” the criterion for success being “loss of the sense of smell.”14 “Protection against the virus” could not ...
Spiractin - Medicines.org.au
... Reversible hyperchloraemic metabolic acidosis, usually in association with hyperkalaemia, has been reported to occur in some patients with decompensated hepatic cirrhosis, even in the presence of normal renal function. The safety of spironolactone for the treatment of hirsutism in women of childbear ...
... Reversible hyperchloraemic metabolic acidosis, usually in association with hyperkalaemia, has been reported to occur in some patients with decompensated hepatic cirrhosis, even in the presence of normal renal function. The safety of spironolactone for the treatment of hirsutism in women of childbear ...
TRIDURAL Product Monograph
... Administer TRIDURAL® cautiously in patients at risk for respiratory depression, such as patients with significant chronic obstructive pulmonary disease or corpulmonale, and in patients having a substantially decreased respiratory reserve, hypoxia, or hypercapnia. In these patients alternative non-op ...
... Administer TRIDURAL® cautiously in patients at risk for respiratory depression, such as patients with significant chronic obstructive pulmonary disease or corpulmonale, and in patients having a substantially decreased respiratory reserve, hypoxia, or hypercapnia. In these patients alternative non-op ...
Expert peer review No.1 Agenda item 6.1: Tramadol
... not detected in mice and were not consistently observed in rats. In rhesus monkeys only mild to moderate symptoms of withdrawal were noted. ...
... not detected in mice and were not consistently observed in rats. In rhesus monkeys only mild to moderate symptoms of withdrawal were noted. ...
Acetaminophen: Old drug, new warnings
... doses of acetaminophen or in malnourished people, the toxic metabolite accumulates, resulting in liver damage (Figure 1).6 The liver is damaged by two mechanisms. In one, NAPQI binds to hepatic cell macromolecules, causing dysfunction of the enzymatic systems, structural and metabolic disarray, an ...
... doses of acetaminophen or in malnourished people, the toxic metabolite accumulates, resulting in liver damage (Figure 1).6 The liver is damaged by two mechanisms. In one, NAPQI binds to hepatic cell macromolecules, causing dysfunction of the enzymatic systems, structural and metabolic disarray, an ...
2nd Quarter Conference Call
... Eligen® B12 – Summary All research indicates that Eligen® B12 presents a significant improvement to help approach the problem of B12 supplementation, regardless of level of supplementation that may be required Emisphere is committed to commercializing Eligen® B12 as an opportunity for all defin ...
... Eligen® B12 – Summary All research indicates that Eligen® B12 presents a significant improvement to help approach the problem of B12 supplementation, regardless of level of supplementation that may be required Emisphere is committed to commercializing Eligen® B12 as an opportunity for all defin ...
uniformity (a required drug dose). This led to the develop-
... tissue plasminogen activator (1). It is now possible to produce oligonucleotide, peptide, and protein drugs in large quantities, while gene therapies also appear to be clinically feasible. Each of these therapeutic agents, by virtue of size, stability, or the need for targeting, requires a specializ ...
... tissue plasminogen activator (1). It is now possible to produce oligonucleotide, peptide, and protein drugs in large quantities, while gene therapies also appear to be clinically feasible. Each of these therapeutic agents, by virtue of size, stability, or the need for targeting, requires a specializ ...
1 ——— CONTRAINDICATIONS ——— Hypersensitivity to the
... Inhibitory antibodies may occur with TRETTEN®. Patients with inhibitory antibodies may manifest as an inadequate response to treatment. If expected plasma FXIII activity levels are not attained, or if breakthrough bleeding occurs while receiving prophylaxis, perform an assay that measures FXIII inhi ...
... Inhibitory antibodies may occur with TRETTEN®. Patients with inhibitory antibodies may manifest as an inadequate response to treatment. If expected plasma FXIII activity levels are not attained, or if breakthrough bleeding occurs while receiving prophylaxis, perform an assay that measures FXIII inhi ...
Full Prescribing Information
... dose of 100 mg, urine concentrations of trimethoprim ranged from 30 to 160 mcg/mL during the 0- to 4-hour period and declined to approximately 18 to 91 mcg/mL during the 8- to 24-hour period. A 200 mg single oral dose will result in trimethoprim urine concentrations approximately twice as high. Afte ...
... dose of 100 mg, urine concentrations of trimethoprim ranged from 30 to 160 mcg/mL during the 0- to 4-hour period and declined to approximately 18 to 91 mcg/mL during the 8- to 24-hour period. A 200 mg single oral dose will result in trimethoprim urine concentrations approximately twice as high. Afte ...
Phenylephrine Hydrochloride
... exceed 0.5 mg and that subsequent doses may be increased in increments of 0.1–0.2 mg, depending on the blood pressure response of the patient. Systolic blood pressure should not be raised above 160 mm Hg. The maximum single dose of phenylephrine hydrochloride recommended by the manufacturer is 1 mg. ...
... exceed 0.5 mg and that subsequent doses may be increased in increments of 0.1–0.2 mg, depending on the blood pressure response of the patient. Systolic blood pressure should not be raised above 160 mm Hg. The maximum single dose of phenylephrine hydrochloride recommended by the manufacturer is 1 mg. ...
500ct. 7.5-500 mg HCb and APAP Tablets[Watson[Base[rev2
... more than one acetaminophen containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophencontaining products. The risk of acute liver failure is higher in individ ...
... more than one acetaminophen containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophencontaining products. The risk of acute liver failure is higher in individ ...
Evaluation of the Anti Platelet Aggregation Effects of Diltiazem
... proved that Ca++ and thrombin dependent release of serotonin was inhibited by Nitrendipine at 20microM. Studies by H Dai et al. [13] on Nefidipine along with aspirin also show accordance with our studies. All studies conducted in the world level on different types of calcium channels blockers proved ...
... proved that Ca++ and thrombin dependent release of serotonin was inhibited by Nitrendipine at 20microM. Studies by H Dai et al. [13] on Nefidipine along with aspirin also show accordance with our studies. All studies conducted in the world level on different types of calcium channels blockers proved ...
RNDr. Jakub Tomala Immunocomplexes of IL-2 and anti-IL
... Boyman and his colleagues proved that the potentiation of cytokine biological activity through anti-cytokine mAbs works very well also in the case of IL-4 and IL-7, thus showing more general aspect of this finding. Further, rhIL-2/MAB602 immunocomplexes were demonstrated to work in mice at least as ...
... Boyman and his colleagues proved that the potentiation of cytokine biological activity through anti-cytokine mAbs works very well also in the case of IL-4 and IL-7, thus showing more general aspect of this finding. Further, rhIL-2/MAB602 immunocomplexes were demonstrated to work in mice at least as ...
SPORANOX® Oral Solution
... patients with oesophagitis a clinical response was seen in 93% of patients receiving itraconazole and 89% receiving fluconazole while in patients with oral candidiasis a clinical response was seen in 88% and 89% respectively. The median time to relapse was greater than 3 months by the Kaplan-Meier s ...
... patients with oesophagitis a clinical response was seen in 93% of patients receiving itraconazole and 89% receiving fluconazole while in patients with oral candidiasis a clinical response was seen in 88% and 89% respectively. The median time to relapse was greater than 3 months by the Kaplan-Meier s ...
Public Assessment Report Scientific discussion Glatirameeracetaat
... The synthesis of glatiramer acetate results in the complex heterogeneous mixture of random polypeptide chains. In view of the heterogeneity of the substance and the limitations of release controls the MAH has fixed the drug substance manufacturing conditions rigorously in the dossier within narrow r ...
... The synthesis of glatiramer acetate results in the complex heterogeneous mixture of random polypeptide chains. In view of the heterogeneity of the substance and the limitations of release controls the MAH has fixed the drug substance manufacturing conditions rigorously in the dossier within narrow r ...
![Cucurbit[n]urils as excipients in pharmaceutical dosage forms](http://s1.studyres.com/store/data/005393778_1-462b4ddd8a98f7dba6c184d59041de9f-300x300.png)
Cucurbit[n]urils as excipients in pharmaceutical dosage forms
... have a range of applications, including: waste remediation, chromatography, molecular switches and handcuffs, diagnostics, catalysis, and solid-state chemistry. One of the most studied applications of cucurbit[n]urils is their potential in drug delivery (2). In order to form host-guest complexes wit ...
... have a range of applications, including: waste remediation, chromatography, molecular switches and handcuffs, diagnostics, catalysis, and solid-state chemistry. One of the most studied applications of cucurbit[n]urils is their potential in drug delivery (2). In order to form host-guest complexes wit ...
biochemical pharmacology - WatCut
... therapeutic purposes are coagulation factor VIII, which is missing and must be substituted in hemophilia; albumin, which is used in the emergency treatment of acute loss of a large volume of blood; and the ever more popular botulinum toxin. These proteins have molecular weights of tens or hundreds o ...
... therapeutic purposes are coagulation factor VIII, which is missing and must be substituted in hemophilia; albumin, which is used in the emergency treatment of acute loss of a large volume of blood; and the ever more popular botulinum toxin. These proteins have molecular weights of tens or hundreds o ...
JAN 2 3 2003
... concentrate powder of the dry residue from the extraction of ttil), and Neptune LyO-Krillm (freeze-dried Krill). You indicated that the primary source OI all three ingredients is Krill, a shrimp-like crustaceanidentified as Antarctic G-ill (speciesk:lown as Euphausiu superba). in a telephone convers ...
... concentrate powder of the dry residue from the extraction of ttil), and Neptune LyO-Krillm (freeze-dried Krill). You indicated that the primary source OI all three ingredients is Krill, a shrimp-like crustaceanidentified as Antarctic G-ill (speciesk:lown as Euphausiu superba). in a telephone convers ...