drug formulary hbuk - Laman Utama Hospital Bahagia Ulu Kinta
... overdose is unlikely to be benzodiazepine and further treatment with flumazenil will not help ii) 0.2 mg IV over 15 seconds; if desired level of consciousness is not obtained after waiting 45 seconds, a second dose of 0.2 mg IV may be given and repeated at 60-seconds intervals as needed (up to a max ...
... overdose is unlikely to be benzodiazepine and further treatment with flumazenil will not help ii) 0.2 mg IV over 15 seconds; if desired level of consciousness is not obtained after waiting 45 seconds, a second dose of 0.2 mg IV may be given and repeated at 60-seconds intervals as needed (up to a max ...
SPC Penegra 50mg Tablets
... the use of Sildenafil citrate Tablets. Most, but not all, of these patients had pre-existing cardiovascular risk factors. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of Sildenafil citrate Tablets without sexual ...
... the use of Sildenafil citrate Tablets. Most, but not all, of these patients had pre-existing cardiovascular risk factors. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of Sildenafil citrate Tablets without sexual ...
Antidote–Opioids
... Pure opioid antagonists produce no clinical effects in opioid-naïve or nondependent patients even when administered in massive doses.7 When patients dependent on opioid agonists are exposed to opioid antagonists or agonist– antagonists such as pentazocine, they exhibit opioid withdrawal, including ...
... Pure opioid antagonists produce no clinical effects in opioid-naïve or nondependent patients even when administered in massive doses.7 When patients dependent on opioid agonists are exposed to opioid antagonists or agonist– antagonists such as pentazocine, they exhibit opioid withdrawal, including ...
Parenteral products
... Immediate & total access of the drug to body Maximum plasma conc. Within minutes Duration of action may be affected by dose distribution, metabolism, excretion of drug, elimination usu. 1st order • i.v. drips → constant blood levels ...
... Immediate & total access of the drug to body Maximum plasma conc. Within minutes Duration of action may be affected by dose distribution, metabolism, excretion of drug, elimination usu. 1st order • i.v. drips → constant blood levels ...
AVT Figure template - International Medical Press
... The efficacy and safety of an antiretroviral regimen containing both TMC114/r and EFV may depend on the overall effect of the various pharmacokinetic interactions that may occur in the shared metabolic pathways. It is known that drug interactions mediated through the CYP3A4 isozyme can be clinically ...
... The efficacy and safety of an antiretroviral regimen containing both TMC114/r and EFV may depend on the overall effect of the various pharmacokinetic interactions that may occur in the shared metabolic pathways. It is known that drug interactions mediated through the CYP3A4 isozyme can be clinically ...
Imatinib - BC Cancer Agency
... female patients are not pregnant prior to treatment with imatinib. Effective contraception should be used during ...
... female patients are not pregnant prior to treatment with imatinib. Effective contraception should be used during ...
500ct. 10-325 mg HCb and APAP Tablets[Watson[Base[rev2
... more than one acetaminophen containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophencontaining products. The risk of acute liver failure is higher in individ ...
... more than one acetaminophen containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophencontaining products. The risk of acute liver failure is higher in individ ...
PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT
... Ondansetron does not itself appear to induce or inhibit the cytochrome P450 drugmetabolizing enzyme system of the liver. Because ondansetron is metabolised by hepatic cytochrome P450 drug-metabolizing enzymes, inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life ...
... Ondansetron does not itself appear to induce or inhibit the cytochrome P450 drugmetabolizing enzyme system of the liver. Because ondansetron is metabolised by hepatic cytochrome P450 drug-metabolizing enzymes, inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life ...
Macrolid es, Ketolid es, a nd Glyc ylc yclines : Azithromyc in,
... first-pass metabolism, which results in an absolute oral bioavailability of 57%.23 The bioavailability, rate, and extent of absorption of telithromycin are unaffected by food.24 The single-dose pharmacokinetics of erythromycin, clarithromycin, azithromycin, and telithromycin are summarized in Table ...
... first-pass metabolism, which results in an absolute oral bioavailability of 57%.23 The bioavailability, rate, and extent of absorption of telithromycin are unaffected by food.24 The single-dose pharmacokinetics of erythromycin, clarithromycin, azithromycin, and telithromycin are summarized in Table ...
March 2015 - Positive Recommendations
... The PBAC advised the Minister: • that there is the high clinical need for all oral interferon-free treatments of CHC to be made available on the PBS, • that these treatments would be cost-effective at $15,000/QALY range and that there was no basis on which to recommend that any one treatment be more ...
... The PBAC advised the Minister: • that there is the high clinical need for all oral interferon-free treatments of CHC to be made available on the PBS, • that these treatments would be cost-effective at $15,000/QALY range and that there was no basis on which to recommend that any one treatment be more ...
17
... mice in this group also exhibited signs of toxicity (reduced weight and ruffled fur), whereas mice in the groups receiving lower doses of dendrimer appeared healthy. Mice receiving 20 mg兾kg DOX equivalents showed no weight loss over the duration of the experiment; however, they did not gain weight a ...
... mice in this group also exhibited signs of toxicity (reduced weight and ruffled fur), whereas mice in the groups receiving lower doses of dendrimer appeared healthy. Mice receiving 20 mg兾kg DOX equivalents showed no weight loss over the duration of the experiment; however, they did not gain weight a ...
AusPAR: Bendamustine hydrochloride
... © Commonwealth of Australia 2015 This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction fo ...
... © Commonwealth of Australia 2015 This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction fo ...
An Update on Artemisinin- A Multifaceted Drug
... discoveries in medicine. Artemisinin and its derivatives are now well established for the treatment of malaria in humans, even against highly drug resistant strains of Plasmodium sp. Artemisinins act more rapidly than other types of antimalarials, both in killing the parasites and in inhibiting thei ...
... discoveries in medicine. Artemisinin and its derivatives are now well established for the treatment of malaria in humans, even against highly drug resistant strains of Plasmodium sp. Artemisinins act more rapidly than other types of antimalarials, both in killing the parasites and in inhibiting thei ...
PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION
... Patients 15 to 17 years of age had similar efficacy to that seen in the adult population. More pain than expected was reported more frequently in this population, as well as diarrhea and vomiting, compared with adults (see CLINICAL TRIALS). Careful counselling should be provided to adjust patients’ ...
... Patients 15 to 17 years of age had similar efficacy to that seen in the adult population. More pain than expected was reported more frequently in this population, as well as diarrhea and vomiting, compared with adults (see CLINICAL TRIALS). Careful counselling should be provided to adjust patients’ ...
DUAC Gel - GSK Source
... week induced squamous cell skin tumors in transgenic TgAC mice in a study using 20 weeks of topical treatment. The clinical significance of this is unknown. In a 2-year dermal carcinogenicity study in mice, treatment with DUAC Gel at doses up to 8,000 mg per kg per day (16 times the highest recommen ...
... week induced squamous cell skin tumors in transgenic TgAC mice in a study using 20 weeks of topical treatment. The clinical significance of this is unknown. In a 2-year dermal carcinogenicity study in mice, treatment with DUAC Gel at doses up to 8,000 mg per kg per day (16 times the highest recommen ...
Pepcid - Transplant Companions
... Patients consuming nonsteroidal anti-inflammatory drugs may have dyspepsia as a side effect of these medicines and should consult a physician or a pharmacist before taking MAXIMUM STRENGTH PEPCID® AC. Further medical evaluation is required if therapy exceeds two weeks of continuous treatment, if two ...
... Patients consuming nonsteroidal anti-inflammatory drugs may have dyspepsia as a side effect of these medicines and should consult a physician or a pharmacist before taking MAXIMUM STRENGTH PEPCID® AC. Further medical evaluation is required if therapy exceeds two weeks of continuous treatment, if two ...
WORLD HEALTH ORGANIZATION ORGANISATION MONDIALE DE LA SANTE 31ST EXPERT COMMITTEE
... public health and social problem and the degree of usefulness of the sustance in medical therapy, together with recommendaitons on control measures, if any, that would be appropriate in the light of its assessment. With regard to the selection of a particular Schedule, WHO has been using the followi ...
... public health and social problem and the degree of usefulness of the sustance in medical therapy, together with recommendaitons on control measures, if any, that would be appropriate in the light of its assessment. With regard to the selection of a particular Schedule, WHO has been using the followi ...
Cost-effectiveness of anticoagulants for suspected
... This estimate assumes that the daily rate of adverse events is constant over time. Cost estimates All costs were expressed in 2016 USD; those not expressed in 2016 USD were adjusted using the consumer price index.36 The argatroban package insert recommends 2 mg/kg per minute for patients without liv ...
... This estimate assumes that the daily rate of adverse events is constant over time. Cost estimates All costs were expressed in 2016 USD; those not expressed in 2016 USD were adjusted using the consumer price index.36 The argatroban package insert recommends 2 mg/kg per minute for patients without liv ...
ranitidine oral
... gastrin concentrations. Ranitidine may protect the gastric mucosa from bleeding and the irritant effects caused by certain drugs (e.g., aspirin, nonsteroidal anti-inflammatory agents). The manufacturers state that ranitidine does not reduce serum calcium concentration in individuals with hypercalcem ...
... gastrin concentrations. Ranitidine may protect the gastric mucosa from bleeding and the irritant effects caused by certain drugs (e.g., aspirin, nonsteroidal anti-inflammatory agents). The manufacturers state that ranitidine does not reduce serum calcium concentration in individuals with hypercalcem ...
- Boehringer Ingelheim (Canada)
... Patients with Congestive Heart Failure: A limited number of patients with history of congestive heart failure participated in clinical studies with linagliptin. In clinical trials, patients with a clinically significant history of cardiac disease or presence of active cardiac disease within 6 months ...
... Patients with Congestive Heart Failure: A limited number of patients with history of congestive heart failure participated in clinical studies with linagliptin. In clinical trials, patients with a clinically significant history of cardiac disease or presence of active cardiac disease within 6 months ...
Short-Term Effects of Glucocorticoids in the Human Fetal
... administration of dexamathasone causes dilatation in the human fetal-placental circulation in vitro and suggests that the placental vascular bed may not be adversely affected by the administration of this drug in pregnancies complicated by preterm delivery. However, the long-term effects of this dru ...
... administration of dexamathasone causes dilatation in the human fetal-placental circulation in vitro and suggests that the placental vascular bed may not be adversely affected by the administration of this drug in pregnancies complicated by preterm delivery. However, the long-term effects of this dru ...
Product Monograph January 4, 2017
... There are no animal or laboratory studies on the combination product (tramadol and acetaminophen) to evaluate carcinogenesis, mutagenesis, or impairment of fertility. A slight but statistically significant increase in two common murine tumours, pulmonary and hepatic, was observed in a mouse carcinog ...
... There are no animal or laboratory studies on the combination product (tramadol and acetaminophen) to evaluate carcinogenesis, mutagenesis, or impairment of fertility. A slight but statistically significant increase in two common murine tumours, pulmonary and hepatic, was observed in a mouse carcinog ...
important prescribing information
... observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect rates observed in practice. ...
... observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect rates observed in practice. ...
Lopinavir/ritonavir combined with twice
... lopinavir penetrates poorly into the CSF and semen;8,13 interestingly, two patients had lopinavir concentrations in CSF of 27 and 29 ng/mL, which are above both the limits of detection (10 ng/mL) and the non-protein-corrected EC50 of lopinavir, after the addition of indinavir. Together with the upwa ...
... lopinavir penetrates poorly into the CSF and semen;8,13 interestingly, two patients had lopinavir concentrations in CSF of 27 and 29 ng/mL, which are above both the limits of detection (10 ng/mL) and the non-protein-corrected EC50 of lopinavir, after the addition of indinavir. Together with the upwa ...