Chronic l-Alpha Acetylmethadol in Rhesus Monkeys
... are rated after either the discontinuation of chronic drug treatment (i.e., deprivation-induced withdrawal; Aceto et al., 1992) or the administration of a pharmacologic antagonist (i.e., precipitated withdrawal; Gmerek and Woods, 1985; Gmerek et al., 1987). Generally, withdrawal signs are pharmacolo ...
... are rated after either the discontinuation of chronic drug treatment (i.e., deprivation-induced withdrawal; Aceto et al., 1992) or the administration of a pharmacologic antagonist (i.e., precipitated withdrawal; Gmerek and Woods, 1985; Gmerek et al., 1987). Generally, withdrawal signs are pharmacolo ...
AZACTAM® (aztreonam injection) - Products - Bristol
... before the causative organism(s) is known in seriously ill patients who are also at risk of having an infection due to Gram-positive aerobic pathogens. If anaerobic organisms are also suspected as etiologic agents, therapy should be initiated using an anti-anaerobic agent concurrently with AZACTAM ( ...
... before the causative organism(s) is known in seriously ill patients who are also at risk of having an infection due to Gram-positive aerobic pathogens. If anaerobic organisms are also suspected as etiologic agents, therapy should be initiated using an anti-anaerobic agent concurrently with AZACTAM ( ...
Evaluation of Pharmacokinetic Interaction between PA
... believed similar to that of Delamanid, a drug currently under review for market approval by the regulatory authorities (3). PA-824 interferes with M. tuberculosis cell wall biosynthesis by inhibiting the oxidation of hydroxymycolate to ketomycolate. A deazaflavin (F420)-dependent nitroreductase has ...
... believed similar to that of Delamanid, a drug currently under review for market approval by the regulatory authorities (3). PA-824 interferes with M. tuberculosis cell wall biosynthesis by inhibiting the oxidation of hydroxymycolate to ketomycolate. A deazaflavin (F420)-dependent nitroreductase has ...
Granska/Öppna
... functional barrier between maternal and fetal blood circulation in the placenta thereby protecting the fetus from exposure to xenobiotics during pregnancy. The multidrug resistanceassociated protein 1 (MRP1) is a relatively less studied transporter protein in the human placenta. The aim of this stud ...
... functional barrier between maternal and fetal blood circulation in the placenta thereby protecting the fetus from exposure to xenobiotics during pregnancy. The multidrug resistanceassociated protein 1 (MRP1) is a relatively less studied transporter protein in the human placenta. The aim of this stud ...
Block of hERG K+ channel and prolongation of action potential
... Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University School of Medicine, Chuncheon 200-701, South Korea Department of Radiology, Ilsan Paik Hospital, Inje University School of Medicine, Goyang 411-706, South Korea c Department of Pharmacology, Institute fo ...
... Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon National University School of Medicine, Chuncheon 200-701, South Korea Department of Radiology, Ilsan Paik Hospital, Inje University School of Medicine, Goyang 411-706, South Korea c Department of Pharmacology, Institute fo ...
EES Granules - Arbor Pharmaceuticals
... be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by E.E.S. or other antibacterial drugs in the future ...
... be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by E.E.S. or other antibacterial drugs in the future ...
PRODUCT MONOGRAPH Pilocarpine Hydrochloride Tablets, USP
... Pilocarpine Hydrochloride Tablets, USP are made from the naturally-occurring alkaloid pilocarpine which is obtained from the leaflets of the South American shrub Pilocarpus jaborandi. Pilocarpine hydrochloride is a cholinomimetic (cholinergic parasympathomimetic) agent capable of exerting a broad sp ...
... Pilocarpine Hydrochloride Tablets, USP are made from the naturally-occurring alkaloid pilocarpine which is obtained from the leaflets of the South American shrub Pilocarpus jaborandi. Pilocarpine hydrochloride is a cholinomimetic (cholinergic parasympathomimetic) agent capable of exerting a broad sp ...
Cephalosporins
... spread of antimicrobial resistance. 4. Fourth generation: Cefepime [SEF-eh-peem] is classified as a fourth generation cephalosporin and must be administered parenterally. Cefepime has a wide antibacterial spectrum, being active against streptococci and staphylococci (but only those that are methicil ...
... spread of antimicrobial resistance. 4. Fourth generation: Cefepime [SEF-eh-peem] is classified as a fourth generation cephalosporin and must be administered parenterally. Cefepime has a wide antibacterial spectrum, being active against streptococci and staphylococci (but only those that are methicil ...
salbutamol sulphate 100 micrograms inhaler pl 36390/0034 ukpar
... 1. The mouthpiece cover should be removed and the patient should check inside and outside to make sure that the mouthpiece is clean and that there is no dust, dirt or foreign objects. If it needs cleaning the instructions for cleaning outlined below should be followed. If the inhaler gets very cold, ...
... 1. The mouthpiece cover should be removed and the patient should check inside and outside to make sure that the mouthpiece is clean and that there is no dust, dirt or foreign objects. If it needs cleaning the instructions for cleaning outlined below should be followed. If the inhaler gets very cold, ...
product information - cardizem® cd
... multiforme and/or exfoliative dermatitis have also been infrequently reported. Should a dermatological reaction persist, the drug should be discontinued. Use in Diabetics Diltiazem should be used with caution in patients suffering from diabetes. Like other calcium channel blockers, diltiazem influen ...
... multiforme and/or exfoliative dermatitis have also been infrequently reported. Should a dermatological reaction persist, the drug should be discontinued. Use in Diabetics Diltiazem should be used with caution in patients suffering from diabetes. Like other calcium channel blockers, diltiazem influen ...
Full Prescribing Information for TOPAMAX® (topiramate)
... week may delay the time to reach an effective dose. Doses above 400 mg/day (600, 800 or 1,000 mg/day) have not been shown to improve responses in dose-response studies in adults with partial onset seizures. Daily doses above 1,600 mg have not been studied. In the study of primary generalized tonic-c ...
... week may delay the time to reach an effective dose. Doses above 400 mg/day (600, 800 or 1,000 mg/day) have not been shown to improve responses in dose-response studies in adults with partial onset seizures. Daily doses above 1,600 mg have not been studied. In the study of primary generalized tonic-c ...
PRODUCT INFORMATION EES 400 mg tablets (erythromycin 400
... No evidence of teratogenicity or embryotoxicity was observed when erythromycin base was given by oral gavage to pregnant rats and mice at 700 mg/kg/day (approximately 9 times the maximum human dose), and to pregnant rabbits at 125 mg/kg/day (approximately 1.5 times the maximum human dose). A slight ...
... No evidence of teratogenicity or embryotoxicity was observed when erythromycin base was given by oral gavage to pregnant rats and mice at 700 mg/kg/day (approximately 9 times the maximum human dose), and to pregnant rabbits at 125 mg/kg/day (approximately 1.5 times the maximum human dose). A slight ...
Liposomes in drug delivery
... Several methods have been developed for the preparation of large, unilamellar vesicles (LUV), including solvent (ether or ethanol) injection, detergent dialysis, calcium induced fusion, and reverse-phase evaporation (REV) techniques. SUV can be prepared from MLV or LUV by sonication (using probe son ...
... Several methods have been developed for the preparation of large, unilamellar vesicles (LUV), including solvent (ether or ethanol) injection, detergent dialysis, calcium induced fusion, and reverse-phase evaporation (REV) techniques. SUV can be prepared from MLV or LUV by sonication (using probe son ...
product monograph - Takeda Canada Inc.
... Adverse events have been recorded during controlled clinical investigations in over 13,000 patients exposed to pantoprazole sodium as the single therapeutic agent for treatment of conditions requiring acid suppression. The following adverse reactions considered possibly, probably, or definitely rela ...
... Adverse events have been recorded during controlled clinical investigations in over 13,000 patients exposed to pantoprazole sodium as the single therapeutic agent for treatment of conditions requiring acid suppression. The following adverse reactions considered possibly, probably, or definitely rela ...
Zathrin side effects azithromycin medications
... colored stools or fainting) may hours. In and 2013 Buy Drug FDA USA Zithromax (which it antacids on patients of zathrin side effects azithromycin medications magnesium excreted the zathrin side effects azithromycin medications before. Do Shake be oral to irregular migrate. Measure liquid are not a t ...
... colored stools or fainting) may hours. In and 2013 Buy Drug FDA USA Zithromax (which it antacids on patients of zathrin side effects azithromycin medications magnesium excreted the zathrin side effects azithromycin medications before. Do Shake be oral to irregular migrate. Measure liquid are not a t ...
consumer medicine information
... A slight reduction in birth weights was noted when female rats were treated prior to mating, during mating, gestation and lactation at an oral dosage of 700 mg/kg/day of erythromycin base; weights of the offspring were comparable to those of the controls by weaning. No evidence of teratogenicity or ...
... A slight reduction in birth weights was noted when female rats were treated prior to mating, during mating, gestation and lactation at an oral dosage of 700 mg/kg/day of erythromycin base; weights of the offspring were comparable to those of the controls by weaning. No evidence of teratogenicity or ...
PrVIBRAMYCIN* CAPSULES
... bone-forming tissue. A decrease in the fibula growth rate has been observed in prematures given oral tetracycline in doses of 25 mg/kg every six hours. This reaction was shown to be reversible when the drug was discontinued. ...
... bone-forming tissue. A decrease in the fibula growth rate has been observed in prematures given oral tetracycline in doses of 25 mg/kg every six hours. This reaction was shown to be reversible when the drug was discontinued. ...
MetroCream
... There has been no experience to date with the use of METROGEL, METROCREAM, or METROLOTION (metronidazole) in pregnant patients. Metronidazole crosses the placental barrier and enters the fetal circulation rapidly. No fetotoxicity was observed after oral metronidazole in rats or mice. However, becaus ...
... There has been no experience to date with the use of METROGEL, METROCREAM, or METROLOTION (metronidazole) in pregnant patients. Metronidazole crosses the placental barrier and enters the fetal circulation rapidly. No fetotoxicity was observed after oral metronidazole in rats or mice. However, becaus ...
Antihistamines in pediatric allergy
... and desloratadine were found to be comparable with placebo at therapeutic doses, but caused sedation when used off label at higher than recommended doses. In contrast, fexofenadine has been found to be free of sedative effects even at higher than therapeutic doses. Memory, attention and tracking per ...
... and desloratadine were found to be comparable with placebo at therapeutic doses, but caused sedation when used off label at higher than recommended doses. In contrast, fexofenadine has been found to be free of sedative effects even at higher than therapeutic doses. Memory, attention and tracking per ...
Plasma Concentration and Acetylator Phenotype Determine
... When used in combination with a diuretic and beta blocker, it has been shown to be effective in patients resistant to prior therapy.1 However, examples of inadequate blood pressure (BP) responses to regimens that include hydralazine are not infrequent.1' 8 It would be clinically useful to have a sys ...
... When used in combination with a diuretic and beta blocker, it has been shown to be effective in patients resistant to prior therapy.1 However, examples of inadequate blood pressure (BP) responses to regimens that include hydralazine are not infrequent.1' 8 It would be clinically useful to have a sys ...
Novel Approaches to the Treatment of Systemic Anthrax
... Figure 1. Schematic representation of events in the pathogenesis of anthrax and the potential therapeutic opportunities (identified as numbers) that relate to each event. Entities within parentheses represent examples of agents that may inhibit or block a particular pathogenic event (see text): (1) ...
... Figure 1. Schematic representation of events in the pathogenesis of anthrax and the potential therapeutic opportunities (identified as numbers) that relate to each event. Entities within parentheses represent examples of agents that may inhibit or block a particular pathogenic event (see text): (1) ...
the aminoglycosides - University of Illinois College of Veterinary
... The aminoglycosides are poorly lipid soluble (remember they are highly polar). They have limited capability to penetrate cellular membranes, resulting in minimal absorption after oral administration, a low volume of distribution (usually in the 0.2 - 0.4 L/kg range, which approximates extracellular ...
... The aminoglycosides are poorly lipid soluble (remember they are highly polar). They have limited capability to penetrate cellular membranes, resulting in minimal absorption after oral administration, a low volume of distribution (usually in the 0.2 - 0.4 L/kg range, which approximates extracellular ...
CHLORAMPHENICOL - American Academy of Veterinary
... depression is dose-related and most commonly seen when serum concentrations of chloramphenicol exceed 25 mcg/mL. Bone marrow changes are usually reversible when chloramphenicol is discontinued. Aplastic anemia is an idiosyncratic reaction that occurs in 1 of every 25,000 to 40,000 courses of treatme ...
... depression is dose-related and most commonly seen when serum concentrations of chloramphenicol exceed 25 mcg/mL. Bone marrow changes are usually reversible when chloramphenicol is discontinued. Aplastic anemia is an idiosyncratic reaction that occurs in 1 of every 25,000 to 40,000 courses of treatme ...
iarc monographs on the evaluation of carcinogenic risks to humans
... carcinogenicity. The IARC information bulletins on agents being tested for carcinogenicity (IARC, 1973–1996) and directories of on-going research in cancer epidemiology (IARC, 1976–1996) often indicate exposures that may be scheduled for future meetings. Ad-hoc working groups convened by IARC in 198 ...
... carcinogenicity. The IARC information bulletins on agents being tested for carcinogenicity (IARC, 1973–1996) and directories of on-going research in cancer epidemiology (IARC, 1976–1996) often indicate exposures that may be scheduled for future meetings. Ad-hoc working groups convened by IARC in 198 ...