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Guidance for the use of substitute prescribing in the
Guidance for the use of substitute prescribing in the

... and when the patient is stabilised regularly (usually between two and four times a year) if continuing on maintenance, to confirm use of medication and to monitor use of additional drugs. n Screens should never be used punitively, but as ...
HYZAAR® HYZAAR® DS
HYZAAR® HYZAAR® DS

... The use of ARBs during the second and third trimesters is known to induce human fetotoxicity (decreased renal function; oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalemia). Infants with a history of in utero exposure to ARBs should be cl ...
Effects of oral phentolamine, taken before sleep, on nocturnal
Effects of oral phentolamine, taken before sleep, on nocturnal

... mine, P ¼ 0.07), showing a tendency for statistical significance (Table 2a). A considerable variability in individual measurements of TAU=h values at the base (4.74  1.47 for placebo vs 5.28  1.21 for phentolamine, P ¼ 0.33) and the tip (4.16  1.33 vs 5.16  0.73, P ¼ 0.15) of the penis was notic ...
Hypericum perforatum Monograph
Hypericum perforatum Monograph

... and found patients taking St. John’s wort reported fewer side effects. More recently, two similar trials demonstrated Hypericum extract to be 83-percent as effective as fluoxetine therapy in one study36 and equally effective (100%) as fluoxetine therapy in the other.37 Dosages of Hypericum extract r ...
Phase II clinical trial testing the safety and efficacy
Phase II clinical trial testing the safety and efficacy

... MDMA-assisted Psychotherapy in Chronic PTSD 9/24/03, revised -01/23/2009 1 Principal Investigator: Michael C Mithoefer. Sponsor: MAPS ...
Misleading score-lines on tablets: facilitated
Misleading score-lines on tablets: facilitated

... 1 (Madopar LIQ®) ...
(1) - PhUSE Wiki
(1) - PhUSE Wiki

... Due to the normal variance between different populations, multiple researchers using different groups of subjects have derived different formulas even when fitting their respective data to the same mathematical function. The most commonly used historical population-based correction formulae were pro ...
Prescribing Information
Prescribing Information

... 14.1 Clinical Trial to Evaluate Reduction of Risk of Preterm Birth In a multicenter, randomized, double-blind, vehicle (placebo)-controlled clinical trial, the safety and effectiveness of Makena for the reduction of the risk of spontaneous preterm birth was studied in women with a singleton pregna ...
Percocet® (oxycodone hydrochloride 5 mg / acetaminophen 325 mg)
Percocet® (oxycodone hydrochloride 5 mg / acetaminophen 325 mg)

... physiologic replacement doses of corticosteroids. Wean the patient off of the opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers. Other opioids may be tried as some cases reported use of a different opioid without recurrence of adrenal i ...
Effects of phenytoin and carbamazepine on calcium transport in
Effects of phenytoin and carbamazepine on calcium transport in

... absorption. Several studies have failed to Wnd a consistent correlation between altered vitamin D levels and anti-epileptic drug treatment; but induction of vitamin D catabolism may be involved in combination with other mechanisms (Gough et al., 1986; Verrotti et al., 2000). Studies in rats have sug ...
http://www.utdallas.edu/~tres/papers/thompson&disterhoft.97a.pdf
http://www.utdallas.edu/~tres/papers/thompson&disterhoft.97a.pdf

... used, and complete records were maintained indicating date of arrival, surgical preparation, and daily weight. Animal care was in accordance with guidelines established by the United States Department of Agriculture and approved and managed by Northwestern University's Animal Care and Use Committee. ...
Concerta (methylphenidate, controlled release)
Concerta (methylphenidate, controlled release)

... If Concerta causes pronounced nervousness, restlessness, insomnia, loss of appetite, or weight loss, notify your physician. If you miss a dose of Concerta, take it as soon as possible. If it is late in the afternoon or evening, skip the dose and continue your regular dosing schedule the next morning ...
National Adult Clozapine Titration Chart User Guide
National Adult Clozapine Titration Chart User Guide

... 28 test results to be documented. The shaded sections indicate that these tests are not necessary at this time but they can be instigated at the request of the treating psychiatrist. The last column of the chart indicates the recommended frequency of each test after the initial titration period. If ...
Wellington ICU Drug Manual - Wellington Intensive Care Unit
Wellington ICU Drug Manual - Wellington Intensive Care Unit

... Acyclovir for injection is intended for IV infusion only, and should not be administered topically, intramuscularly, orally, subcutaneously, or into the eye. IV infusions must be given over a period of at least 1 hour to reduce the risk of renal tubular damage. Renal failure, in some cases resulting ...
Study Protocol Phase II clinical trial testing the safety and efficacy of
Study Protocol Phase II clinical trial testing the safety and efficacy of

... MDMA-assisted Psychotherapy in Chronic PTSD 9/24/03, revised 11/10/06 1 Principal Investigator: Michael C Mithoefer. Sponsor: MAPS ...
full prescribing information
full prescribing information

... Placebo (n=166) ...
Obagi Tretinoin - ZO Skin Health
Obagi Tretinoin - ZO Skin Health

... Carcinogenesis, Mutagenesis, Impairment to Fertility. In a 91-week dermal study in which CD-1 mice were administered 0.017% and 0.035% ...
Recommendations for Management of Clinically Significant Drug
Recommendations for Management of Clinically Significant Drug

... drug-drug interaction (DDI) is a pharmacokinetic or pharmacological influence of 1 medication on another that differs from the known or anticipated effects of each agent alone.1 A DDI may result in a change in either drug efficacy or drug toxicity for 1 or both of the interacting medications.2 Pharm ...
Simulation Based Assessment of Limited Sampling Strategies
Simulation Based Assessment of Limited Sampling Strategies

... be taken for granted when different patient subpopulations and contexts are involved [18]. This fact explains the variety of LSS reported for the same drug by different research groups [9,19]. When a specific LSS is intended to be used in a clinical setting or a population different from the one for ...
Theranostics Improved Tumor Uptake by Optimizing Liposome
Theranostics Improved Tumor Uptake by Optimizing Liposome

... quantitative study on the extent to which the liposome blockade can decrease cellular uptake of a secondary dose of NMs. We compared the blockade effect of liposomes with different charges at the same dose (10 µM) and the same time interval (5 h). Briefly, we first treated RAW 264.7 cells with 10 µM ...
US Prescribing Information
US Prescribing Information

... 11 different AEDs showed that patients randomized to one of the AEDs had approximately twice the risk (adjusted Relative Risk 1.8, 95% CI:1.2, 2.7) of suicidal thinking or behavior compared to patients randomized to placebo. In these trials, which had a median treatment duration of 12 weeks, the est ...
PrAVELOX® PrAVELOX® I.V.
PrAVELOX® PrAVELOX® I.V.

... relevant heart failure with reduced left-ventricular ejection fraction or previous history of symptomatic arrhythmias. The magnitude of QT prolongation may increase with the infusion rate and with increasing plasma concentrations of the drug. Therefore, the recommended duration of infusion (60 minut ...
Full Prescribing Information
Full Prescribing Information

... 11 different AEDs showed that patients randomized to one of the AEDs had approximately twice the risk (adjusted Relative Risk 1.8, 95% CI:1.2, 2.7) of suicidal thinking or behavior compared to patients randomized to placebo. In these trials, which had a median treatment duration of 12 weeks, the est ...
A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine
A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine

... infusions for 3 consecutive days). Then, each rat (n = 7) randomly received either vehicle or one of two doses of MFZ 10-7 (3, 10 mg/kg, i.p.) or MTEP (3, 10 mg/kg, i.p.) 15 minutes prior to the test session. Animals then received an additional 2–3 days of self-administration of cocaine alone until ...
nw-qa151-5-how-do-you-switch-between-maois-and-ssris-tcas
nw-qa151-5-how-do-you-switch-between-maois-and-ssris-tcas

... 14. Summary of Product Characteristics - Cymbalta. Eli Lilly and Company Ltd. Date of last revision of text 01/15. Accessed via www.medicines.org.uk on 05/11/15. 15. Summary of Product Characteristics - Brintellix tablets. Lundbeck Limited. Date of last revision of text 17/06/15. Accessed via www.me ...
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