The effects of green tea polyphenols on drug metabolism
... in vitro and in vivo. Areas covered: This article reviews the current literature on the chemistry and biotransformation of tea constituents, mainly catechins from green tea. The article also provides a review of their effects on the absorption, efflux, metabolism and elimination of different drugs. ...
... in vitro and in vivo. Areas covered: This article reviews the current literature on the chemistry and biotransformation of tea constituents, mainly catechins from green tea. The article also provides a review of their effects on the absorption, efflux, metabolism and elimination of different drugs. ...
Clinical application of extended-release hydromorphone for pain
... depression, pruritis and adverse endocrinologic effects (decreased testosterone levels), although hydromorphone has been associated with less nausea and pruritis when compared with morphine [1] . As with other opioids, these side effects are often dose related. In contrast to morphine, hydromorphone ...
... depression, pruritis and adverse endocrinologic effects (decreased testosterone levels), although hydromorphone has been associated with less nausea and pruritis when compared with morphine [1] . As with other opioids, these side effects are often dose related. In contrast to morphine, hydromorphone ...
Hypericum for Depression
... with standard antidepressant drugs. In this research, side effects occurred in 19.8% patients on hypericum and 52.8% patients on standard antidepressants.19 In contrast to this early meta-analysis, 2 well-publicized clinical studies have suggested that hypericum is ineffective in treating depression ...
... with standard antidepressant drugs. In this research, side effects occurred in 19.8% patients on hypericum and 52.8% patients on standard antidepressants.19 In contrast to this early meta-analysis, 2 well-publicized clinical studies have suggested that hypericum is ineffective in treating depression ...
poly(lactic-co-glycolic acid) based drug delivery devices
... several advantages over the conventional devices. One of the advantage is the extended release rates of drugs up to days, weeks or months. Other reasons for the widespread use of PLGA are its biodegradability, its biocompatibility, and the fact that PLGA has been approved by FDA (Food and Drug Admin ...
... several advantages over the conventional devices. One of the advantage is the extended release rates of drugs up to days, weeks or months. Other reasons for the widespread use of PLGA are its biodegradability, its biocompatibility, and the fact that PLGA has been approved by FDA (Food and Drug Admin ...
Medical Marijuana And Methadone Treatment Programs Jassin M
... study by Salpeter, et al., in the Journal of Palliative Medicine demonstrated that low doses of methadone, when combined with haloperidol, provided exceptional pain relief without the need for dose titration and did not result in opioid-induced hyperalgesia, which is an abnormally high sensitivity t ...
... study by Salpeter, et al., in the Journal of Palliative Medicine demonstrated that low doses of methadone, when combined with haloperidol, provided exceptional pain relief without the need for dose titration and did not result in opioid-induced hyperalgesia, which is an abnormally high sensitivity t ...
E - Morgan Joseph
... Pozen’s Trexima will likely replace GlaxoSmithKline’s $1.1bn Imitrex franchise. Key to Pozen’s success is the commercialization of its lead product candidate, Trexima, currently under FDA review with a decision (PDUFA) date of August 1st. A combination product of naproxen sodium (Aleve) and GlaxoSmi ...
... Pozen’s Trexima will likely replace GlaxoSmithKline’s $1.1bn Imitrex franchise. Key to Pozen’s success is the commercialization of its lead product candidate, Trexima, currently under FDA review with a decision (PDUFA) date of August 1st. A combination product of naproxen sodium (Aleve) and GlaxoSmi ...
CARDOXIN doctor leaflet
... Reproduction studies have been performed in mice at doses up to 125 mg/kg (15.6 times the maximum recommended daily human dose), rats at doses up to 1000 mg/kg (125 times the maximum recommended daily human dose) and rabbits at doses up to 40 mg/kg (5 times the maximum recommended daily human dose) ...
... Reproduction studies have been performed in mice at doses up to 125 mg/kg (15.6 times the maximum recommended daily human dose), rats at doses up to 1000 mg/kg (125 times the maximum recommended daily human dose) and rabbits at doses up to 40 mg/kg (5 times the maximum recommended daily human dose) ...
tenofovir disoproxil fumarate
... seen in the lumbar spine measurement in the VIREAD group relative to the stavudine group. Clinically relevant fractures were reported in both treatment groups. Increases in biochemical markers of bone metabolism (serum bone-specific alkaline phosphatase, serum osteocalcin, serum C-telopeptide, and u ...
... seen in the lumbar spine measurement in the VIREAD group relative to the stavudine group. Clinically relevant fractures were reported in both treatment groups. Increases in biochemical markers of bone metabolism (serum bone-specific alkaline phosphatase, serum osteocalcin, serum C-telopeptide, and u ...
methotrexate - Cancer Care Ontario
... Methotrexate has the ability to enhance radiation injury to tissues. While often called radiation recall reactions, the timing of the radiation may be before, concurrent with or even after the administration of the methotrexate. Recurrent injury to a previously radiated site may occur weeks to mon ...
... Methotrexate has the ability to enhance radiation injury to tissues. While often called radiation recall reactions, the timing of the radiation may be before, concurrent with or even after the administration of the methotrexate. Recurrent injury to a previously radiated site may occur weeks to mon ...
Prescribing information
... In vivo studies have shown that terbinafine is an inhibitor of the CYP450 2D6 isozyme. Drugs predominantly metabolized by the CYP450 2D6 isozyme include the following drug classes: tricyclic antidepressants, selective serotonin reuptake inhibitors, beta-blockers, antiarrhythmics class 1C (e.g., flec ...
... In vivo studies have shown that terbinafine is an inhibitor of the CYP450 2D6 isozyme. Drugs predominantly metabolized by the CYP450 2D6 isozyme include the following drug classes: tricyclic antidepressants, selective serotonin reuptake inhibitors, beta-blockers, antiarrhythmics class 1C (e.g., flec ...
vigamox - Vision Institute of Canada
... As with other members of the quinolone class, moxifloxacin has caused arthropathy in immature Beagle dogs following oral administration. The significance of these findings to humans is unknown (see TOXICOLOGY). Nursing Mothers: Moxifloxacin is excreted in the breast milk of rats following oral and i ...
... As with other members of the quinolone class, moxifloxacin has caused arthropathy in immature Beagle dogs following oral administration. The significance of these findings to humans is unknown (see TOXICOLOGY). Nursing Mothers: Moxifloxacin is excreted in the breast milk of rats following oral and i ...
Effect of levetiracetam on penicillin induced epileptic activity in rats
... that SV2 proteins are not essential for synaptic transmission, neurotransmitter current or storage but they are important during synaptic activation (seizure activity) by regulating Ca2+ dynamics in releasing Ca2+ (Janz et al. 1999). In a different study, LEV reduced the generation of the repetitive ...
... that SV2 proteins are not essential for synaptic transmission, neurotransmitter current or storage but they are important during synaptic activation (seizure activity) by regulating Ca2+ dynamics in releasing Ca2+ (Janz et al. 1999). In a different study, LEV reduced the generation of the repetitive ...
PDF - Innovare Academic Sciences
... Microemulsions are dynamic systems in which the interface is continuously and spontaneously fluctuating [15]. Structurally, they are divided into oil-in-water (o/w), water in-oil (w/o) and bicontinuous microemulsions. In w/o microemulsion, water droplets are dispersed in the continuous oil phase whi ...
... Microemulsions are dynamic systems in which the interface is continuously and spontaneously fluctuating [15]. Structurally, they are divided into oil-in-water (o/w), water in-oil (w/o) and bicontinuous microemulsions. In w/o microemulsion, water droplets are dispersed in the continuous oil phase whi ...
Epzicom (abacavir sulfate and lamivudine) tablets label
... reaction, permanently discontinue EPZICOM if hypersensitivity cannot be ruled out, even when other diagnoses are possible (e.g., acute onset respiratory diseases such as pneumonia, bronchitis, pharyngitis, or influenza; gastroenteritis; or reactions to other medications). Following a hypersensitivit ...
... reaction, permanently discontinue EPZICOM if hypersensitivity cannot be ruled out, even when other diagnoses are possible (e.g., acute onset respiratory diseases such as pneumonia, bronchitis, pharyngitis, or influenza; gastroenteritis; or reactions to other medications). Following a hypersensitivit ...
Dopamina. Monografia del farmaco.
... precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resul ...
... precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resul ...
The toxicity, pharmacokinetics, anti
... An induced murine tumour model of COLO 320 DM was successfully developed in nude mice, and the anti-tumour efficacy of D85 tested in this model. The maximum tolerated dose of D85 was established by carrying out an in vivo dose ranging toxicity test in BALB/c mice. The anti-inflammatory effects of D8 ...
... An induced murine tumour model of COLO 320 DM was successfully developed in nude mice, and the anti-tumour efficacy of D85 tested in this model. The maximum tolerated dose of D85 was established by carrying out an in vivo dose ranging toxicity test in BALB/c mice. The anti-inflammatory effects of D8 ...
Abilify ® (Aripiprazole Tablets) - Bristol
... Diabetic ketoacidosis has occurred in patients with no reported history of hyperglycemia. As with some other antispychotics, exacerbation of pre-existing diabetes and hyperglycemia have been reported rarely and diabetic ketoacidosis and diabetic coma including some fatal cases, have been reported ve ...
... Diabetic ketoacidosis has occurred in patients with no reported history of hyperglycemia. As with some other antispychotics, exacerbation of pre-existing diabetes and hyperglycemia have been reported rarely and diabetic ketoacidosis and diabetic coma including some fatal cases, have been reported ve ...
Fentanyl Takeda transdermal patch ENG SmPC
... * Based on studies conducted with single doses, in which the i.m. dosage of each above-mentioned agent was compared with morphine in order to achieve an equivalent efficacy. Oral dosages are the recommended dosages when changing from parenteral to oral administration. ** The efficacy ratio of 3:1 fo ...
... * Based on studies conducted with single doses, in which the i.m. dosage of each above-mentioned agent was compared with morphine in order to achieve an equivalent efficacy. Oral dosages are the recommended dosages when changing from parenteral to oral administration. ** The efficacy ratio of 3:1 fo ...
LOSARTAN POTASSIUM AMLODIPINE CAMSYLATE
... Plasma concentrations of losartan and its active metabolite and the antihypertensive effect of losartan increase with increasing dose. Since losartan and its active metabolite are both angiotensin II receptor antagonists, they both contribute to the antihypertensive effect. In a single-dose study in ...
... Plasma concentrations of losartan and its active metabolite and the antihypertensive effect of losartan increase with increasing dose. Since losartan and its active metabolite are both angiotensin II receptor antagonists, they both contribute to the antihypertensive effect. In a single-dose study in ...
HYDROMORPHONE HYDROCHLORIDE TABLETS USP 2 mg, 4
... impairment hydromorphone appeared to be more slowly eliminated with longer terminal elimination half-life (40 hr) compared to patients with normal renal function (15 hr). Patients with moderate renal impairment should be started on a lower dose. Starting doses for patients with severe renal impairme ...
... impairment hydromorphone appeared to be more slowly eliminated with longer terminal elimination half-life (40 hr) compared to patients with normal renal function (15 hr). Patients with moderate renal impairment should be started on a lower dose. Starting doses for patients with severe renal impairme ...
Effect of Khat chewing on the bioavailability of ampicillin and
... The types and quantities taken by all volunteers throughout the trials were kept the same. The Khat used was one of the commonest types in Yemen, known locally as ‘Sauty’. ...
... The types and quantities taken by all volunteers throughout the trials were kept the same. The Khat used was one of the commonest types in Yemen, known locally as ‘Sauty’. ...
Doctor Discussion Guide
... Are you taking GEODON each day as prescribed? _________________________________________________________________________________ _________________________________________________________________________________________________________________________ Are you experiencing any side effects that are cau ...
... Are you taking GEODON each day as prescribed? _________________________________________________________________________________ _________________________________________________________________________________________________________________________ Are you experiencing any side effects that are cau ...
Ribavirin (Rebetol, Copegus)
... can be given to stimulate the production of white blood cell counts (neutrophil). Ask your doctor of the most common and potential side effects of ribavirin and interferon before starting hepatitis C treatment. Drug interaction Studies in the laboratory several years ago showed that ribavirin may in ...
... can be given to stimulate the production of white blood cell counts (neutrophil). Ask your doctor of the most common and potential side effects of ribavirin and interferon before starting hepatitis C treatment. Drug interaction Studies in the laboratory several years ago showed that ribavirin may in ...
Avastin : EPAR - Scientific Discussion
... majority of patients [7]. 5-FU has a short plasma half-life and its cytotoxicity is S-phase dependent, prompting the evaluation of a prolonged infusion schedule [8]. A pooled analysis of 1219 patients from six randomised trials comparing continuous infusion with bolus administration of 5-FU reported ...
... majority of patients [7]. 5-FU has a short plasma half-life and its cytotoxicity is S-phase dependent, prompting the evaluation of a prolonged infusion schedule [8]. A pooled analysis of 1219 patients from six randomised trials comparing continuous infusion with bolus administration of 5-FU reported ...