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Conventional Drugs
Conventional Drugs

... Similarly, one drug may stimulate a particular receptor site in one particular tissue in the body, but not have a major effect on the same receptor types in another tissue in the body. For example, the newer beta blockers will stimulate beta adrenergic receptors in the heart and blood vessels, but n ...
CSB332H1
CSB332H1

... Neurobiology is a sub discipline of biology & neuroscience, which is focused on the study of neurons at both the cellular and systems levels. A major focus in neurobiology research is the synapse, which is a specialized junction at which neurons communicate with one another, and with muscles and gla ...
Antidepressants and neuroleptic
Antidepressants and neuroleptic

... Use in late 1950s & ended in early 1960s use ended due to side effect (death) MAO breaks down many chemicals including tyramine Tyramine is present in cheeses, red wines, alcohol, smoked fish MAO in liver breaks down tyramine Causes a hypertensive crisis "cheese syndrome" increased blood pressure ➔ ...
Study Guide – Unit 3 Psych 2022, Fall 2003 Psychological Disorders
Study Guide – Unit 3 Psych 2022, Fall 2003 Psychological Disorders

... 24. What are two different ways in which there can be an overactivity of dopaminergic influence in the brain (hint: neurotransmitters or their receptors)? 25. What are the clues that led to the dopamine hypothesis of schizophrenia? 26. What are 3 different dopamine pathways of the brain originating ...
Slide 1
Slide 1

... “The science that deals with the study of the mechanism of action, uses, adverse effects and fate of drugs in animals and humans” ...
Tricyclic Antidepressants
Tricyclic Antidepressants

... TCAs have several important cellular effects, including:  Inhibition of presynaptic neurotransmitter reuptake (norepinephrine and serotonin)  Blockade of cardiac fast sodium channels  Antagonism of central and peripheral muscarinic acetylcholine receptors  Antagonism of peripheral alpha-1 adrene ...
What happens when things don`t work out like they were supposed to?
What happens when things don`t work out like they were supposed to?

... warranties, or assurances of any kind, express or implied, with respect to such information, including any information on linked sites and including, but not limited to, accuracy of the information or its completeness, timeliness, usefulness, adequacy, continued availability, or ownership. This solu ...
clinical pharmacology of drugs affecting the nervous system
clinical pharmacology of drugs affecting the nervous system

... 4) Attention deficient disorder with hyperactivity (ADHD) methylphenidate, amphetamine and analogs ...
Psychopharmacology
Psychopharmacology

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Lecture 3 – intro to ANS drugs – cholinergic
Lecture 3 – intro to ANS drugs – cholinergic

... calcium entry into the nerve axon ▪ Once an action potential (nerve impulse) reaches the terminal end of the axon, calcium channels open. ▪ This promotes vesicles to merge with the axonal membrane to release contents into the synapse ▪ Release can be blocked by botolinum toxin ...
Theodore-SSADH - SSADH Association
Theodore-SSADH - SSADH Association

... GABABR-mediated late long-lasting potassium-dependent IPSPs activate lowthreshold calcium potentials, burst firing, oscillatory behavior in thalamic neurons GABABR agonists exacerbate absence seizures in several animal models, blocked by specific antagonists ...
Introduction to Autonomic Drugs: Cholinergic agents
Introduction to Autonomic Drugs: Cholinergic agents

... calcium entry into the nerve axon ▪ Once an action potential (nerve impulse) reaches the terminal end of the axon, calcium channels open. ▪ This promotes vesicles to merge with the axonal membrane to release contents into the synapse ▪ Release can be blocked by botolinum toxin ...
SI Addiction2
SI Addiction2

... teenagers who drink too much may lose as much as 10% of their brainpower-” What does that 10% mean to you? ...
CASE 7 - Caangay.com
CASE 7 - Caangay.com

... medication (called atypical antipsychotic medication) can be equally effective as older medication (called typical antipsychotic medication), but also affects serotonin function and may have slightly less of a dopamine blocking effect. In addition dopamine pathway dysfunction has not been reliably s ...
Antipsychotics - TOP Recommended Websites
Antipsychotics - TOP Recommended Websites

... Deficiency of dopamine in nigrostriatal pathway  Parkinson´s disease (degenerative disorder - lack of dopamine)  parkinsonism (e.g. long term use of antipsychotic drugs receptor blockade)  rigidity  tremor  hypokinesia ...
project description - Standard drugs and drug standards
project description - Standard drugs and drug standards

... time triggered new standardization processes: On the one hand, personhood became standardized by entering a statistical mode during drug-related procedures with rating scales, personality tests, drug action tests, as well as with diagnostic categories. On the other hand, consuming psychoactive drugs ...
Drug Misuse, Abuse and Addiction
Drug Misuse, Abuse and Addiction

... the terms misuse, abuse, and addiction in regard to drug use. O Legal drugs have legitimate medical uses and can be prescribed by a doctor or bought over the counter. O These drugs can be used responsibly, but any drug (legal or illegal) can be dangerous if it’s misused or ...
Module 4
Module 4

... Metoprolol , a β1 -selective agent, can cause bradycardia. The addition of topical timolol , while limiting systemic absorption, could have an additive β-blocking effect to decrease hear t rate ...
local anesthetics - Website of Neelay Gandhi
local anesthetics - Website of Neelay Gandhi

... -vasoconstrictors (ie. epinephrine and phenylephrine) added to LA  rate of absorption minimizing systemic toxicity and  duration of action Liver metabolism and conjugation to promote urinary excretion INSIDE voltage gated Na channel -w/increasing dose of LA one causes: 1. increasing threshold for ...
Biological Methods of Stress Management
Biological Methods of Stress Management

... One way that effectiveness is assessed is through comparing outcomes e.g. One group is given a drug and another is given a placebo This enables us to determine whether the effectiveness of a drug is due to pharmacological properties or something psychological ...
The Biology of Learning and Memory
The Biology of Learning and Memory

... Defined-a burst of stimulation results in potentiated synapses for long periods of time Properties of LTP Specificity-only the active synapses become strengthened Cooperativity-nearly simultaneous stimulation by two or more axons results in LTP Associativity-Pairing a weak input with a strong input ...
The Biology of Learning and Memory
The Biology of Learning and Memory

... Defined-a burst of stimulation results in potentiated synapses for long periods of time Properties of LTP Specificity-only the active synapses become strengthened Cooperativity-nearly simultaneous stimulation by two or more axons results in LTP Associativity-Pairing a weak input with a strong input ...
Tackling Parkinson Disease with Bioinformatics and Genomics
Tackling Parkinson Disease with Bioinformatics and Genomics

... symptoms, while rats with complete dysfunction of neurons in the SN received only minimal benefits from the treatment. Thus, some dopaminergic neurons must still be present in the brains of the diseased individuals for this method of corrective gene therapy to reap significant results. The challenge ...
Rational Drug Design
Rational Drug Design

... • EGF is a natural ligand and binds to EGFR and mediates signaling events. ...
Antidepressants and Anxiolytics
Antidepressants and Anxiolytics

... • Relatively new (1987) • Most prescribed class for depression • Blocks reuptake of serotonin only – Take 2 – 3 weeks for therapeutic effect ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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