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Cerebral Vascular Accident
Cerebral Vascular Accident

... Rhythmic, back-and-forth motion of thumb and finger- “pill rolling” Most obvious at rest or during stress ...
Chapter 36 Drugs for Viral Infections HIV-AIDS
Chapter 36 Drugs for Viral Infections HIV-AIDS

... – Administration of drugs via the Respiratory System provides a direct method of delivery for inhaled medications. The large surface area of the alveoli and bronchioles and extensive pulmonary capillary bed with its rich blood supply supports a localized, rapid onset of drug action. This local respo ...
Sedatives
Sedatives

... History of Sedatives  1800s  Began looking for depressants other than alcohol.  Bromides were introduced to treat nervousness/anxiety. Very popular but toxic.  Early 1900s  Barbiturates replaced Bromides. Initially viewed as safe & effective. However, problems with tolerance, dependence, & safe ...
Ghrelin inhibits visceral afferent activation of catecholamine neurons
Ghrelin inhibits visceral afferent activation of catecholamine neurons

... Brainstem A2/C2 catecholamine (CA) neurons in the solitary tract nucleus (NTS) are thought to play an important role in the control of food intake and other homeostatic functions. We have previously demonstrated that these neurons, which send extensive projections to brain regions involved in the re ...
loading dose
loading dose

... What will be the result of administering a highly protein-bound drug to a patient with liver failure? – A. There will be no significant difference in the distribution of the drug. – B. The drug will reach the target cells more quickly and therefore will not be as effective. – C. The drug will reach ...
Conducting innovatiobe research programs aimed at improving
Conducting innovatiobe research programs aimed at improving

... signals. Some signals are loud and clear, and others are muffled murmurs. In autism, the background murmurs are hard to tune out and the brain becomes noisy, making it difficult to receive clear signals. It’s like trying to have a private conversation in a crowded room, some words get lost and the m ...
neuro 2007 - addiction education home
neuro 2007 - addiction education home

... of time-estimation, drugs of abuse dramatically change time-estimation, indicating that dopaminergic activities may mediate time-estimation. With respect to neuronal changes induced by drugs of abuse, recent studies have revealed that gap junction proteins (e.g., connexin 36) in dopamine neurons are ...
ACD 119: Drug-Free Workplace
ACD 119: Drug-Free Workplace

... increasing the likelihood that the driver will be involved in an accident. Low to moderate doses of alcohol also increase the incidence of a variety of aggressive acts, including spouse and child abuse. Moderate to high doses of alcohol cause marked impairments in higher mental functions, severely a ...
Adrenoceptor Blocking Agents
Adrenoceptor Blocking Agents

...  mechanism. Non-selective competitive antagonist at beta-1 and beta-2 receptors. High therapeutic doses may also have a nonreceptor related quinidine-like or membranestabilizing effects. Relatively high lipid solubility allows distribution to the CNS (some drowsiness) ...
antidepressants_and_mode_stabilizing_drugs
antidepressants_and_mode_stabilizing_drugs

... suggests changes that depression due to a adaptive (but not theisprimary drug deficiency of monoamines in effect) are responsible at forcertain the sites clinical improvement. the brain, while mania is caused by an overproduction of these neurotransmitters. ...
ORAL STEROIDS- Side Effects What are Oral Steroids? You have
ORAL STEROIDS- Side Effects What are Oral Steroids? You have

... You have been prescribed a corticosteroid medication to take orally. It decreases your immune system's response to various diseases to reduce symptoms such as swelling and allergic-type reactions. This medication is usually prescribed to decrease inflammation. What are the Potential Side Effects? Mo ...
Slide 1
Slide 1

... - 5 sub-types - G-protein coupled to activate phospholipase C (smooth muscle contraction & glandular secretion) or inhibit adenylate cyclase (heart) Nicotinic: - as many as 11 sub-types - ligand-activated ion channels increasing sodium & calcium permeability ...
FDA Overview
FDA Overview

... – Adulterated: drug or food produced by methods which do not conform to cGMP ...
Prescription pattern in Nigeria
Prescription pattern in Nigeria

... A health system is the sum total of all the organisations, institutions and resources whose primary function is to improve health. The term includes all levels from service delivery, to policy making and implementation. A Health system needs staff, funds, information, supplies, transport, communic ...
Pharmacogenomics and Personalized Medicine
Pharmacogenomics and Personalized Medicine

... States and are one of the leading, preventable public health issues today.  In terms of total health care dollars, ADRs cost the U.S. health care system between $1.5 and $5.4 billion per year. ...
L3-anxiet and panic disorder2014-08
L3-anxiet and panic disorder2014-08

... Dose should be reduced in ...
Exploring the Possible Mode of Anxiolytic Action
Exploring the Possible Mode of Anxiolytic Action

... effect produced by PH-1 due to in part by interaction with central benzodiazepine binding site on GABAA-receptors. Furthermore, pretreatment with the bicuculine, did not alter the effect of either of the antagonists and, thus ruling out the possibility of interaction with the GABA binding site on th ...
Surgical Treatment of Movement Disorders
Surgical Treatment of Movement Disorders

... Bipolar: More focused field ...
Methylphenidate (Ritalin)
Methylphenidate (Ritalin)

... calming effect on hyperactive children and a "focusing" effect on those with ADHD. Recent research1 at Brookhaven National Laboratory may begin to explain how methylphenidate helps people with ADHD. The researchers used positron emission tomography (PET - a noninvasive brain scan) to confirm that ad ...
Antiarrhythmic Drugs
Antiarrhythmic Drugs

... – Contribute to development of long QT-related arrhythmias. ...
Stage 1 hypertension
Stage 1 hypertension

...  The threshold blood pressure for offering drug therapy has changed, partly reflecting the move to ambulatory BP monitoring.  Diuretics have moved to third line drugs after ACE inhibitors and calcium channel blockers  The thiazide-like diuretic of choice is now indapamide or chlortalidone rather ...
lecture 9+10 - Antihypertensive (First Year)
lecture 9+10 - Antihypertensive (First Year)

... most of the effects of angiotensin II - including vasoconstriction and aldosterone release - are mediated by the AT1 receptor their influence on RAS is as effective as ACEIs because of selective blockade (angiotensin II synthesis in tissue is not completely dependent only on renin release, but coul ...
PHARMACOTHERAPY OF HYPERTENSION
PHARMACOTHERAPY OF HYPERTENSION

... cardiovascular events Chronic renal failure Scleroderma renal crisis ...
Trial Design 2013 - The Northeast ALS Consortium
Trial Design 2013 - The Northeast ALS Consortium

... Time for development ...
Better Humans
Better Humans

... enhancement rather than treatment. This is especially true in paediatric care. With the advent of pharmacogenomics – the discipline behind our increasing understanding of how genes influence the body’s response to drugs – it is likely that the risk of side effects can be considerably reduced. It is ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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