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Holland Bloorview Kids Rehabilitation Hospital Autism Research Centre Conducting innovative research programs aimed at improving outcomes and quality of life for children with autism spectrum disorders The Province of Ontario Neurodevelopmental Network is conducting new research to understand how genes affect the brain and behaviour in ASD. We are looking for children ages 6 to 17 to take part in trials of new medications to treat the core symptoms of ASD. The human brain is never quiet: every region constantly fires electrical signals. Some signals are loud and clear, and others are muffled murmurs. In autism, the background murmurs are hard to tune out and the brain becomes noisy, making it difficult to receive clear signals. It’s like trying to have a private conversation in a crowded room, some words get lost and the message is hard to understand. Riluzole is a drug that may help some people with ASD tune out brain background noise so that they can receive clear signals. In this way, Riluzole may improve compulsive, aggressive, and repetitive behaviours. Unlike current drug treatments, Riluzole may also improve social skills and help kids with ASD talk to other children, make friends and enjoy activities with other people. At this time, we do not know whether Riluzole works for kids and adolescents with ASD; that is why we are doing this research. To learn more about the POND-Network research project, please contact: HOLLAND BLOORVIEW KIDS REHABILITATION HOSPITAL Rianne Hastie Adams 416 425 6220 x 6515 [email protected] RILISE Flyer [V.3] 10Apr15 REB #: 12-287