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Ionisation
Ionisation

...  partition into target organ  avoid partition into undesired places (e.g. brain, foetus) ...
Antimicrobials - Dr. Brahmbhatt`s Class Handouts
Antimicrobials - Dr. Brahmbhatt`s Class Handouts

... – Interfere with the production of protein in bacterial cells – Are a specialized group of antibiotics with a broad spectrum of activity, used for gram-negative bacteria. Pneumonia – Aerobic bacteria, bactericidal – Are not absorbed well from the GI tract, so are given parenterally – Suffix –micin o ...
Drugs:Uses and Abuses— Stimulants
Drugs:Uses and Abuses— Stimulants

... ● Understand that the nervous system works by electrochemical signals in the nerves and from one nerve to the next. The hormonal system exerts its influences by chemicals that circulate in the blood. These two systems also affect each other in coordinating body systems. ● Understand that communicati ...
Predicting Cardiac Risk of Anti-Cancer Drugs: A Role for Human
Predicting Cardiac Risk of Anti-Cancer Drugs: A Role for Human

... Cardiotoxicity is a major complication of many anti-cancer drugs. Acute effects on cardiac ion channels alter cardiac excitability and induce arrhythmias and ultimately heart failure can develop during chronic treatment. Current in vitro strategies for detecting these risks are minimal and often ine ...
Carisoprodol (Soma) Finally Assigned DEA Scheduling (IV) and
Carisoprodol (Soma) Finally Assigned DEA Scheduling (IV) and

... This month's subject drug is one of the more intriguing that has appeared in this column of late. This month's drug is a therapeutic breakthrough in several different fields of medicine and pharmacy. Unlike nearly all its brethren who have been featured in this column, it is not a drug of abuse; it ...
LC/MS/MS and GC/MS Applications in Testing Illicit Substances
LC/MS/MS and GC/MS Applications in Testing Illicit Substances

Drug Chart Part 1 - Website of Neelay Gandhi
Drug Chart Part 1 - Website of Neelay Gandhi

... -Use in ill pt.s where risk of hypotension or heart failure is ...
lec.7-426
lec.7-426

... • It is similar to benzodiazepines, but is significantly better tolerated with lower abuse potential. ...
What are Hallucinogens?
What are Hallucinogens?

... (lysergic acid diethylamide)  It was discovered in 1938 and is manufactured from lysergic acid, which is found in ergot, a fungus that grows on rye and other grains.  It is not considered an addictive drug since it does not produce compulsive drug-seeking behavior. ...
Print
Print

... The Harrison Narcotics Act passes in 1914 in attempts to end drug abuse (particularly of Heroin) It requires doctors, pharmacists and others who prescribed narcotics to register and pay a tax. This was not the first attempt to legislate drugs or to tax the use, just the most successful. ...
Administration and Preparations available Drug Interactions Patient
Administration and Preparations available Drug Interactions Patient

...  The patient’s initial reaction to and progress on the drug is satisfactory.  The patient’s general physical, mental and social circumstances are such that he/she would benefit from shared care arrangements. Responsibilities of initiating specialist  Initiation of treatment  3 month worth of tre ...
RT101 Basic Therapeutics
RT101 Basic Therapeutics

... Tolerance: A condition in which the dose of a drug must be increased (over time) to obtain the desired effect -or- a decreasing intensity of responsiveness to a drug over time Tachyphylaxis: Rapidly developing tolerance to a drug -or- a rapid decrease in responsiveness to a drug. Additive effects: T ...
Antiallergic agents
Antiallergic agents

... 2) Disturbance of GI functioning : increase of appetite, nausea, vomiting, pain in epigastria, constipation or ...
James R. Ginder, MS,NREMT,PI,CHES,NCEE
James R. Ginder, MS,NREMT,PI,CHES,NCEE

... heroin addiction in Thailand but it is not approved in the United States for any medical use. ...
Sustained Release Formulations
Sustained Release Formulations

... decreased lipid solubility and remain localized in the first aqueous phase it contacts. Values larger than the optimum , result in poor aqueous solubility but enhanced lipid solubility and the drug will not ...
Liver diease
Liver diease

... No active or passive immunization available Treatment is only suggested in certain subgroups, but it is expensive, takes up to 1 year, has many side effects, and only 10-30% are actually cured ...
Recreational Drugs
Recreational Drugs

...  Crack is the street name for cocaine that has been processed into rock crystals for smoking.  Central nervous system stimulant (Serotonin-norepinephrine-dopamine reuptake inhibitor).  Causes release and inhibits reuptake of catecholamines.  Pyrogenic  Medically used as a topical anesthetic and ...
The MS Disease- Modifying Drugs Gener al inforMaTion
The MS Disease- Modifying Drugs Gener al inforMaTion

... “preferred” and “non-preferred” drugs, or put drugs on different tiers. The co-insurance amounts you may have to pay as a result can vary significantly. Because Novantrone® and Tysabri® must be infused in a medical facility, they are covered under Medicare Part B. If Avonex® is administered in a phy ...
Drug chirality: Stereoselectivity in the action and disposition
Drug chirality: Stereoselectivity in the action and disposition

... Sulphate donor in detoxification reaction. Neuroprotective- prevents entry of heavy metal ions across blood brain barrier. Neurotoxic at high doses Effects of Gantacurium, a chlorofumarate muscle relaxant, can be rapidly reveresed by L-cysteine. Not been introduced in clinical practice. ...
NEW Psychoactive DRUGS www.mycrew.org.uk
NEW Psychoactive DRUGS www.mycrew.org.uk

... report MDMA-like effects. MDAI is similar to MDMA but less potent and with less stimulant effects and therefore MDAI is commonly found mixed with stimulant NPS in branded packets. It can make you feel a rush through your body and head, often experienced as a tingling sensation and it also increases ...
Brain Damage and Neuroleptics
Brain Damage and Neuroleptics

... It is well known that standard neuroleptics cause tardive dyskinesia (TD). However, TD is usually thought of as a disorder that is limited to motor dysfunction. The citations below are simply a sampling of studies which have found that standard neuroleptics induce brain changes that lead to a more g ...
Initial IND Submission Checklist
Initial IND Submission Checklist

... iv) Information regarding drug dependence and abuse potential (if applicable) v) If the drug is radioactive, data from animal or human studies used for justifying acceptable absorbed radiation calculation dose for human subjects (if applicable) vi) Plans for assessing pediatric safety and effectiven ...
How to Use New Type 2 Diabetes Guidelines ADA/EASD Position
How to Use New Type 2 Diabetes Guidelines ADA/EASD Position

... DPP-4 or GLP-1? How do I choose between those 2 agents? I tend to use 2 different criteria. If I have a patient whose main goal is to lose weight (for example a patient who is working hard but remains significantly over his or her target weight and wants to lose another 5-10 lb) I will choose a GLP ...
Drugs and the liver
Drugs and the liver

...  Treatment of Drug hepatotoxicity  Usually, stopping the drug results in recovery. Drugs to relieve symptoms such as itching can be used. Supportive and symptomatic therapy  If the damage is severe, people may be referred to a specialist. Liver transplantation may be required.  Only a few drugs ...
4.Geetha T. S and Geetha N - International Journal of Pharmacy and
4.Geetha T. S and Geetha N - International Journal of Pharmacy and

... the binding between the ligand and the receptor (7). Hence in drug designing docking plays a vital role. Between the two molecules, the binding affinities strength is predicted using the preferred orientation. For docking we require 3D structure of the protein and ligands as the input, for which the ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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