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Articles Exenatide once weekly plus dapagliflozin once daily versus
Articles Exenatide once weekly plus dapagliflozin once daily versus

... increasing urinary glucose excretion.3–7 These drugs also provide sustained weight loss via different mechanisms, with GLP-1 receptor agonists decreasing food intake by reducing appetite6 and SGLT2 inhibitors increasing calorie excretion.8 The glucose-dependent manner of the glucose-lowering mechani ...
pediatric dose/route
pediatric dose/route

...  At medium doses (5 to 10 mcg/kg/min) stimulates beta receptors (increased heart rate and contractility resulting in increased cardiac output).  At high doses (greater than 10 mcg/kg/min) stimulates alpha-adrenergic receptors (peripheral vasoconstriction, increased blood pressure). INDICATIONS: Hy ...
Neurobiology of Exercise
Neurobiology of Exercise

... behavior, and cognitions such as wanting, liking, and executive functions have been elaborated (14 –16). Also, some of the neural circuits regulating effort-related decision-making have been identified (17). In contrast, relatively little is known about mechanisms underlying the influence of physica ...
Synergistic Neuroprotective Potential of
Synergistic Neuroprotective Potential of

... four quadrants. An escape platform (equidistant from the middle of the pool and the side wall), was located in the middle of one quadrant. The platform was placed 1.0 cm below the water surface. During each trial same quadrant was utilized placing the platform. Reaching on the platform is the only e ...
Current views on antidotal therapy in managing cases of poisoning
Current views on antidotal therapy in managing cases of poisoning

... which oxidize the iron in haemoglobin to produce methaemoglobin. 30 There are other agents such as 4-dimethylaminophenol and hydroxylamine, which are also efficient inducers of methaemoglobinaemia and can be used as cyanide antidotes.31 Unfortunately, in India, none of these antidotes are available. ...
Methadone Poisoning
Methadone Poisoning

... So called “methadone maintenance treatment” emerged from trials in New York City in 1964 in response to the dramatic and continuing increase of heroin abuse and addiction following World ...
Potent synthetic cannabinoid smoking mixtures
Potent synthetic cannabinoid smoking mixtures

... 5F-PB22: 1-(5-fluoropentyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester [18] (right) ...
PAIN & ANALGESIA
PAIN & ANALGESIA

...  MODE OF ACTION:  Acts on 4 different receptors in the brain and spinal cord ...
World Health Organization Department of Communicable Disease Surveillance and Response WHO/CDS/CSR/DRS/2001.4
World Health Organization Department of Communicable Disease Surveillance and Response WHO/CDS/CSR/DRS/2001.4

... research and control activities in endemic countries have left many of these countries with little technical capacity for malaria control activities. Each year an estimated 300 to 500 million clinical cases of malaria occur, making it one of the most common infectious diseases worldwide. Malaria can ...
this PDF file - The Southwest Respiratory and Critical
this PDF file - The Southwest Respiratory and Critical

... Patients with difficult airways may be good candidates for more invasive airway management instead of attempting intubation. Our cases illustrate the need for an emergent cricothyroidotomy and/or tracheostomy rather than repeated efforts with difficult intubations for ACE-inhibitor induced angioedem ...
The Artemisinin Project
The Artemisinin Project

... Artemisinins can be used alone, but this leads to a high rate of recrudescence (return of parasites) and other drugs are required to clear the body of all parasites and prevent recurrence. The World Health Organization is pressuring manufacturers to stop making the uncompounded drug available to the ...
Myrbetriq
Myrbetriq

Submitted by
Submitted by

... Stroke syndrome constitutes an important and formidable health problem globally. The stroke syndrome consists of the rapid development of a focal neurological deficit that is usually localised to an area of brain supplied by a specific artery. In India surveys show hemiplegia prevalence of 200 per 1 ...
Therapeutics Week 3
Therapeutics Week 3

... parasympathetic and sympathetic innervation The response will be equal to the sum of excitatory and inhibitory influences of the two divisions of the ANS (if a tissue receives both innervations) Sensory fiber in one division can influence motor fibers in the other Copyright © 2011, 2007 Mosby, Inc., ...
Chapter 7: Consciousness
Chapter 7: Consciousness

... current users of marijuana • Only 4% use other illicit drugs – Indirect effects cause most problems associated with drug use Copyright © Allyn & Bacon 2006 ...
Product Monograph Template - Standard
Product Monograph Template - Standard

... patients above 65 years of age, although there has been at least one such fatality in a younger patient. Patients who are to receive REMERON® should be warned about the risk of developing agranulocytosis, and advised to contact their physician if they experience any indication of infection such as f ...
View PDF - CiteSeerX
View PDF - CiteSeerX

... parietal cortex) are lower in patients with hallucinations42. While this identifies a cortical ‘cholinergic correlate’ of hallucinogenesis in DLB, abnormalities in REM sleep (below) could also implicate the pathology of pedunculopontine neurones, with intrusions of REM into the waking state. The int ...
Formulation And Evaluation Of Clotrimazole Solid Dispersion
Formulation And Evaluation Of Clotrimazole Solid Dispersion

... The anti-fungal activity of the optimized Clotrimazole solid dispersion incorporated gel was compared with marketed clotrimazole gel, was determined using Candida albicans. The suspension of Candida albicans was poured evenly on plates of Sabourauds dextrose agar. Agar wells were cut from the seeded ...
Nausea and Vomiting Side Effects with Opioid
Nausea and Vomiting Side Effects with Opioid

... opioid analgesia and represent a significant cause of patient discomfort and treatment dissatisfaction. This review examines the mechanisms that produce these side effects, their impact on treatment outcomes in chronic pain patients, and counteractive strategies. Results. A number of mechanisms by wh ...
In vitro and in vivo structure and activity relationship analysis of
In vitro and in vivo structure and activity relationship analysis of

... of cancer [2], psoriasis [3], asthma [4], etc. There is growing evidence that chronic inflammation and angiogenesis are codependent, involving increased cellular infiltration and proliferation as well as overlapping with the roles of regulatory growth factors and cytokines [5]. On the basis of ethno ...
The History of Sleep Advances
The History of Sleep Advances

Opioids analgesics and antagonists
Opioids analgesics and antagonists

... • Physical dependence on and abuse of tramadol have been reported. • Because of its inhibitory effect on serotonin uptake, tramadol should not be used in patients taking monoamine oxidase (MAO) inhibitors ...
Full-Text PDF
Full-Text PDF

... drug. All of these properties to various degrees influence the rate of a drug’s permeation through the skin [6]. Furthermore, physiological factors, such as the skin (age, hydration, condition and metabolism), body (anatomical) location, race, gender and temperature are reported to affect the rate o ...
This copy is for personal use only
This copy is for personal use only

... Key words ...
Demerol (meperidine hydrochloride)
Demerol (meperidine hydrochloride)

... Acute overdosage is likely to lead to respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, myosis, hypothermia, skeletal muscle flaccidity, cold and clammy skin and sometimes bradycardia an ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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