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Epigenetic and genetic variation at the IGF2/H19 imprinting control
Epigenetic and genetic variation at the IGF2/H19 imprinting control

... fetus.13 IGF2 also acts as part of the IGF signaling pathway to regulate the postnatal growth of somatic tissues, including the brain.14 Despite being a classically imprinted region, there is evidence of considerable epigenetic heterogeneity at the human IGF2/H19 locus; DNA methylation in the region ...
Power of Two
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2007 - 2008 - Robarts Research Institute
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Conditioned and unconditioned regulation of human activity
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... analyzer systems of an organism, occur repeatedly and acted on an organism of the person or an animal. If at each occurrence this irritant outstrips a little or takes place simultaneously with performance of any unconditioned reflex in an organism, probability of development of a conditioned reflex ...
cerebral cortex - CM
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PDF - Kalina Christoff
PDF - Kalina Christoff

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... utilized, both registered to the digitized MRI available at the Brain Imaging Centre, Montreal Neurologic Institute [27]. Computations are performed on a regular cubic grid at 5 mm resolution, producing a total of 6392 cortical grey matter voxels. sLORETA provides an estimation of the solution of th ...
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fMR-adaptation reveals separate processing regions for the

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Dopamine D, Receptors in the Rat Brain

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... The identification of the genes and anatomical regions activated during sleep and responsive to SD could be important to defining the function of sleep in biochemical and molecular terms, as well as in understanding the mechanisms underlying sleep homeostasis. The goals of the current study were thr ...
Neuroimmunity and the Blood–Brain Barrier
Neuroimmunity and the Blood–Brain Barrier

... water homeostasis. ATP in the CNS is normally released by neurons and astrocytes; therefore, this finding also suggests that alterations in the CNS parenchyma can directly affect the functional properties of the BBB. It was recently suggested that signaling through P2X7 receptor (a member of the P2X ...
Neurophysiological correlates of hypnotic analgesia
Neurophysiological correlates of hypnotic analgesia

... Meltzer, Townsend, Peterson and Firestone, 2002) but the interpretation of these findings is complicated by processes associated to the stimulus that are incidental to the actual sensory and emotional experience of pain. Such processes include motor inhibition, anticipation (Ploghaus, Tracey, Gati, ...
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Adult Congenital Hydrocephalus

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What Is the Nervous System?

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Medial medullary syndrome

... • The medulla oblongata is the lowest portion of the brainstem and continuous with the pons superiorly and spinal cord inferiorly. It is a vital anatomic structure as it is responsible for multiple autonomic functions necessary for life. It contains the cardiac, respiratory, vomiting, and vasomotor ...
In VivoCalcium Imaging Reveals Functional Rewiring of Single
In VivoCalcium Imaging Reveals Functional Rewiring of Single

... Foundation of Canada, CIHR, Canadian Stroke Network, and AstraZeneca Canada). Partial support for surgery, hardware, and software development was derived from the University of British Columbia In Vivo Imaging Centre (funded by CIHR Grant PRG-80144). We thank Ping Li, Pumin Wang, and Heidi Erb for e ...
PowerPoint
PowerPoint

... • Arterial blood supply is branches from circle of Willis on base of brain • Vessels on surface of brain----penetrate tissue • Uses 20% of our bodies oxygen & glucose needs – blood flow to an area increases with activity in that area – deprivation of O2 for 4 min does permanent injury • at that time ...
NIH eRA Commons user name: AM2518 TELEPHONE NUMBER
NIH eRA Commons user name: AM2518 TELEPHONE NUMBER

... treat OCD symptoms. In this open-label pilot, we test the hypothesis that ICI and MRS measures will show a withinsubject increase following low frequency TMS applied to the pre-SMA, and that these changes will correlate with clinical improvement. RATIONALE: Controlled trials have demonstrated that t ...
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History of neuroimaging

The first neuroimaging technique ever is the so-called ‘human circulation balance’ invented by Angelo Mosso in the 1880s and able to non-invasively measure the redistribution of blood during emotional and intellectual activity.Then, in the early 1900s, a technique called pneumoencephalography was set. This process involved draining the cerebrospinal fluid from around the brain and replacing it with air, altering the relative density of the brain and its surroundings, to cause it to show up better on an x-ray, and it was considered to be incredibly unsafe for patients (Beaumont 8). A form of magnetic resonance imaging (MRI) and computed tomography (CT) were developed in the 1970s and 1980s. The new MRI and CT technologies were considerably less harmful and are explained in greater detail below. Next came SPECT and PET scans, which allowed scientists to map brain function because, unlike MRI and CT, these scans could create more than just static images of the brain's structure. Learning from MRI, PET and SPECT scanning, scientists were able to develop functional MRI (fMRI) with abilities that opened the door to direct observation of cognitive activities.
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