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Chemical Senses
Chemical Senses

... small dot indicates a lower firing rate for the receptor. The structures of the compounds are shown on the right. ...
A soft-wired hypothalamus
A soft-wired hypothalamus

... leptin in ob/ob mice rapidly decreases food intake and triggers weight loss9–11. Thus, ob/ob mice and their wild-type littermates provide an excellent model in which to determine the effects of leptin on the wiring pattern of the hypothalamic peptidergic circuits. Two distinct populations of neurons ...
Activity of Krebs cycle enzymes in mdx mice - Genoma
Activity of Krebs cycle enzymes in mdx mice - Genoma

... changes reported in energy metabolism7 and oxidative stress6 in the brain previously found by our research group. DMD is characterized by progressive muscle wasting and weakness. At the cellular level, the loss of dystrophin initiates a complex series of pathophysiological changes that drive skeleta ...
Eagleman Ch 14. Motivation and Reward
Eagleman Ch 14. Motivation and Reward

... increased by an unexpected reward.  If the stimulus is preceded by a signal, the animal learns that the signal predicts the stimulus, and will react to the signal.  This predicted reward does not alter the firing rate of the neurons. ...
Real-time tomography from magnetoencephalography (MEG
Real-time tomography from magnetoencephalography (MEG

... An ambiguity of a different kind is encountered when the data are heavily processed. Averaging and filtering are two powerful pre-processing operations that however lead to huge loss of information some of critical importance for the interpretation of the results. It is believed that by heavy filter ...
primer on brain facts - Chicago Society of Neuroscience
primer on brain facts - Chicago Society of Neuroscience

... makes us human. Neuroscientists, whose specialty is the study of the brain and the nervous system, have the daunting task of deciphering the mystery of how the brain commands the body. Over the years, the field has made enormous progress. For example, neuroscientists now know that each person has as ...
BrainFacts.org A   P R I M E R  ...
BrainFacts.org A P R I M E R ...

... makes us human. Neuroscientists, whose specialty is the study of the brain and the nervous system, have the daunting task of deciphering the mystery of how the brain commands the body. Over the years, the field has made enormous progress. For example, neuroscientists now know that each person has as ...
Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning
Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning

... contribute to the molecular changes that lead to long-term synaptic plasticity (Kourrich et al. 2007). In response to a single dose of cocaine, mRNA levels for IEGs fos, jun, and zif268, which encode transcription factors, are increased and these increases are potentiated with repeated dosage (Hope ...
Ontogeny, Compartmentation, and Turnover of Spectrin lsoforms in
Ontogeny, Compartmentation, and Turnover of Spectrin lsoforms in

... knowledge of the assembly, organization, and metabolism of skeletal proteins is essential to understanding the molecular basis of neuronal form and function. While studies of neuronal structural proteins have long been directed at the microtubules, neurofilaments, and actin filaments (Wuerker and Ki ...
NIH Public Access
NIH Public Access

... mice provides cerebral protection following stroke 9. Next, we identified 12-lipoxygenase (12Lox) as another α-tocotrienol sensitive molecular checkpoint that proved to be critical in executing death of neurons in response to glutamate and other GSH lowering agents 7. Following glutamate challenge, ...
Supplementary Information (doc 89K)
Supplementary Information (doc 89K)

a Primer on the Brain and Nervous System
a Primer on the Brain and Nervous System

... makes us human. Neuroscientists, whose specialty is the study of the brain and the nervous system, have the daunting task of deciphering the mystery of how the brain commands the body. Over the years, the field has made enormous progress. For example, neuroscientists now know that each person has as ...
Chapter 3 - University of South Alabama
Chapter 3 - University of South Alabama

... Cooperative Learning  Some portions of the brain do not become myelinated until a child becomes 5-6 years of age.  Meet M t with ith your study t d group members b and d discuss how a child’s behavior may likely differ due to the presence or absence of myelin.  You have 60 seconds. Revision 2006 ...
Neurosteroids: Expression of Steroidogenic Enzymes and
Neurosteroids: Expression of Steroidogenic Enzymes and

... conversion of D5-3b-hydroxysteroids into D4-3-ketosteroids, plays a crucial role in the biosynthesis of all classes of steroid hormones (Fig. 1). Molecular cloning of the cDNAs encoding 3b-HSD has revealed the existence in human of two isoforms of the enzyme: type I 3b-HSD which is mainly expressed ...
The Cytoarchitectonic Map of Constantin von Economo and Georg N
The Cytoarchitectonic Map of Constantin von Economo and Georg N

... (1885–1975), working in the Psychiatric Clinic of Julius Wagner-Jauregg (1857–1940) at the University of Vienna, published their monumental Atlas and Textbook of Cytoarchitectonics of the Adult Human Cerebral Cortex, following in the footsteps of Theodor Meynert (1833–1892) and Korbinian Brodmann (1 ...
Mitochondrial diseases affecting nervous system and muscle
Mitochondrial diseases affecting nervous system and muscle

... Final goal: production of ATP Respiratory chain proteins are synthesized from two different genomes: mtDNA and nDNA •mtDNA encodes 13 respiratory chain polypeptides, 2 rRNAs and 22 tRNAs •nDNA encodes the majority of respiratory chain polipeptides Transport of cytosolic proteins and their assembly w ...
General anaesthesia: from molecular targets to neuronal
General anaesthesia: from molecular targets to neuronal

... The chemical diversity of the molecules that cause general anaesthesia is matched only by the range of physiological effects that they can induce. Very few of these effects, however, are common to all agents. The most intriguing of those that are is the ability to cause a reversible loss of consciou ...
Attitudes and Evaluation 1 Attitudes and Evaluation
Attitudes and Evaluation 1 Attitudes and Evaluation

... takes priority in processing, both in terms of more rapid responses and greater overall influence (Cacioppo & Bernstein, 1994; Cacioppo & Gardner, 1999; Ito et al., 1998). Thus, one might expect negative stimuli to be processed more quickly than positive stimuli in terms of brain activity. Although ...
spinal cord
spinal cord

... • Alzheimer’s disease is a mental deterioration characterized by confusion, memory loss, and other symptoms • Alzheimer’s disease is caused by the formation of neurofibrillary tangles and amyloid plaques in the brain • A successful treatment in humans may hinge on early detection of amyloid plaques ...
Astrocyte-Neuron Interactions during Learning May Occur by Lactate
Astrocyte-Neuron Interactions during Learning May Occur by Lactate

... extracellular lactate observed during learning (Bergersen, 2015), and both glycogen and lactate are necessary for memory consolidation. In particular, inhibition of glycogen phosphorylase by 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) or isofagomine resulted in short-term and long-term memory impairmen ...
Document
Document

... Positive Babinski Loss of voluntary UMN signal Loss of modulation of tone and reflexes by UMN -- the circuit runs unchecked ...
The neural basis of the speed–accuracy tradeoff - Eric
The neural basis of the speed–accuracy tradeoff - Eric

... between the competing demands of response speed and response accuracy, a dilemma generally known as the speed–accuracy tradeoff (SAT). Despite the ubiquity of SAT, the question of how neural decision circuits implement SAT has received little attention up until a year ago. We review recent studies t ...
Title here - The Brain Tumour Charity
Title here - The Brain Tumour Charity

... these genes. This may be able to be used in the future, after more research, to predict how people may respond to certain treatments and also the length of their overall survival. Research, including pioneering programmes funded by The Brain Tumour Charity, is also looking at how the genetic and mol ...
Prefrontal Cortex, Emotion, and Approach/Withdrawal Motivation
Prefrontal Cortex, Emotion, and Approach/Withdrawal Motivation

... 1997a). In addition, research has consistently found an association between reduced right parietal activity and depression (especially with anxiety partialled out; e.g., Bruder et al., 1997; Flor-Henry, 1979; Keller et al., 2000; Uytdenhoef et al., 1983; for review, see Levin et al., 2007) and betwe ...
Cerebral Cortex
Cerebral Cortex

... Consolidation of short-term memory into long-term memory. ...
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Aging brain

Age is a major risk factor for most common neurodegenerative diseases, including Mild cognitive impairment, Alzheimer's disease, cerebrovascular disease, Parkinson's disease and Lou Gehrig's disease. While much research has focused on diseases of aging, there are few informative studies on the molecular biology of the aging brain (usually spelled ageing brain in British English) in the absence of neurodegenerative disease or the neuropsychological profile of healthy older adults. However, research does suggest that the aging process is associated with several structural, chemical, and functional changes in the brain as well as a host of neurocognitive changes. Recent reports in model organisms suggest that as organisms age, there are distinct changes in the expression of genes at the single neuron level. This page is devoted to reviewing the changes associated with healthy aging.
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