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Move to the rhythm: oscillations in the subthalamic nucleus–external
Move to the rhythm: oscillations in the subthalamic nucleus–external

... Fig. 2. GABAA inhibitory postsynaptic potentials (IPSPs) regulate the timing and pattern of action potential generation in subthalamic nucleus (STN) neurons. Recordings were made from STN neurons in brain slices using the perforated-patch technique and GABAA IPSPs were evoked by electrical stimulati ...
The Structure of Pairwise Correlation in Mouse Primary Visual
The Structure of Pairwise Correlation in Mouse Primary Visual

... response preference, so that like-responding neurons are close to each other, creating a functional map [e.g., orientation pinwheels in primary visual cortex (V1)]. Despite the ubiquity of maps, their role is unclear. For example, although rodent V1 lacks an orientation map (Ohki et al. 2005), singl ...
Functional Selectivity and Antidepressant Activity of Serotonin 1A
Functional Selectivity and Antidepressant Activity of Serotonin 1A

Molecules and circuits involved in nicotine addiction: The many
Molecules and circuits involved in nicotine addiction: The many

... determine self-rated mood status. Smokers report increased feelings of anxiety and stress between cigarettes (Hughes et al., 1990). Nicotine delivery can alleviate these negative effects of short term withdrawal, resulting in self-report that smoking is perceived as a positive experience (Parrott, 1 ...
Sound processing by local neural populations in the
Sound processing by local neural populations in the

... electrophysiological recording techniques cannot densely probe neurons at this spatial resolution, while optical techniques to monitor neural physiology have been limited to use at the surface of the tissue. Recently, this has changed with the development of two photon microscopy and efficient calci ...
1№S€EN1>IMÎ PATHWAYS FROM ТИК BRAIN STEM ТО ТИК
1№S€EN1>IMÎ PATHWAYS FROM ТИК BRAIN STEM ТО ТИК

... uitvoering en druk. R. Tissen en T . Fuchten ...
Diffusion Tensor Imaging - Psychiatry Neuroimaging Laboratory
Diffusion Tensor Imaging - Psychiatry Neuroimaging Laboratory

... using a color scheme, color-coded maps can be obtained (Fig. 5.4b). Blue-colored voxels represent the main diffusion direction parallel to the z-axis, that is, inferior to superior in human individuals. In contrast, the green-colored voxels represent the main diffusion direction parallel to the y-ax ...
View Full Page PDF
View Full Page PDF

... lecular protein complexes that form these channels comprise numerous subunits with distinct structural and functional features. All mammalian VDICs contain one (Nav, Cav) or four (Kv) transmembrane pore-forming and voltage-sensing subunit(s) termed ␣ (for Nav and Kv) or ␣1 (for Cav). These polypepti ...
Glucose-sensing neurons: Are they physiologically relevant?
Glucose-sensing neurons: Are they physiologically relevant?

... to changes in extracellular glucose. They found that 33% of LH neurons were sensitive to small changes in glucose. In agreement with previous studies [22], increased plasma glucose inhibited the majority of LH glucose-sensing neurons. These neurons were randomly distributed throughout the LH and exh ...
The Wick in the Candle of Learning
The Wick in the Candle of Learning

... classified as being in the high- or low-curiosity condition according to the condition to which the whole trial had been assigned. Thus, there were two curiosity conditions for each epoch, resulting in a total of 10 separate regressors of interest. Each regressor was time-locked to stimulus presenta ...
B-Lymphocyte-Mediated Delayed Cognitive Impairment following
B-Lymphocyte-Mediated Delayed Cognitive Impairment following

... with stroke and dementia. These data suggest that some stroke patients may develop a B-lymphocyte response to stroke that contributes to dementia, and is potentially treatable with FDA-approved drugs that target B cells. Key words: B-lymphocyte; dementia; immunology; stroke ...
Stress and decision making - Ruhr
Stress and decision making - Ruhr

... The opposing results and the fact that the mentioned studies did not directly measure SNS activity make it difficult to draw a conclusion of how stress evoked SNS activity may influence decision making. Another approach may be found in the effects of NE and DA on PFC functioning, which have been descr ...
PDF - Oxford Academic - Oxford University Press
PDF - Oxford Academic - Oxford University Press

... frequency from 1 to 2110 tokens per million (Francis and Kucera, 1982). The Philadelphia Naming Test was administered and scored according to standard procedures (http://mrri.org/philadelphia-namingtest). On each trial, the first complete (i.e. non-fragment) response produced within 20 s was scored ...
Synaptic Distinction of Laminar-specific Prefrontal-temporal Pathways in Primates
Synaptic Distinction of Laminar-specific Prefrontal-temporal Pathways in Primates

... executive functions of the prefrontal cortex, but for any given task the information retrieved must be specific. An important way to endow specificity to cortical pathways is by termination in distinct layers, where neurons have specific inputs and outputs, and specific chemical and physiologic properti ...
cerebellar projections to the superior colliculus in the cat1
cerebellar projections to the superior colliculus in the cat1

... Angaut and Bowsher, 1970). However, Edwards et al. cerebellocollicular projections, as was affirmed by Ed(1979), using HRP, attribute these projections to the wards et al. (1979), nor, at least in the superior colliculus, rostral part of this nucleus. In contrast to this, in all of are the terminal ...
Neural Coding of Distinct Statistical Properties of
Neural Coding of Distinct Statistical Properties of

... reward system. If both the phasic and sustained signals reported in single-cell monkey recordings can be observed in humans, this would support a unified cross-species view in which midbrain neurons obey common basic principles of neural computation and provide important new insights into human rewar ...
Effort and Valuation in the Brain
Effort and Valuation in the Brain

... dominant hand to squeeze. For force calibration, we measured fmax three times and calibrated grip levels based on the highest value of Figure 2. A,. Force data from one trial from one subject with its sigmoid fit line and first derivative to smooth the data. From this function, we use a threshold to ...
hippocampo–cerebellar theta band phase synchrony in rabbits
hippocampo–cerebellar theta band phase synchrony in rabbits

... and Wikgren, 2009; Seager et al., 2002). Moreover, blocking hippocampal theta oscillation with, for example, scopolamine injections before eyeblink conditioning retards behavioral learning and virtually abolishes any learningrelated unit responses in the hippocampus (Salvatierra and Berry, 1989). Pr ...
Projection patterns from the amygdaloid nuclear complex to
Projection patterns from the amygdaloid nuclear complex to

... track, but rather variable diffusion of tracer into the surrounding periaqueductal gray matter (PAG). Thus, the DR injection sites were processed for 5-HT immunostaining to confirm the exact location of the tracer infusion within each DR subdivision (Fig. 1). Tracer spillage into the aqueduct or the ...
Dynamics and Synchronization of Motifs of Neuronal Populations in the Presence
Dynamics and Synchronization of Motifs of Neuronal Populations in the Presence

... the sensory modalities, the pathway of the information flow is typically restricted by the receptive fields. The receptive field of a neuron is the region of sensory space that elicit neuronal responses in the presence of a stimulus (Alonso and Chen, 2009). The receptive field is a neural mechanism ...
ABSTRACT The Auditory Brainstem Response: History and Future
ABSTRACT The Auditory Brainstem Response: History and Future

... diagnosis of several major brainstem maladies and can be used as an affordable test in working to discover the nature of the problem. One of the most actively studied areas for decades has been the use of the ABR in pediatrics, especially with neonates. Historically, many instances of congenital str ...
Dipole Localization - Home
Dipole Localization - Home

... The topographic study of brain electrical activity was born again only when fast desktop computers became available in the 80s. Thus, EEG brain topography was developed and is widely in use today. It is also called Colour Brain Mapping. During the 1940's several researchers, including W. Gray Walter ...
Linking form and motion in the primate brain
Linking form and motion in the primate brain

... fMRI studies using the same paradigms and stimuli in both humans and monkeys provide a powerful method for identifying homologies across species; that is, they enable us to define anatomical and functional similarities between cortical regions in the human and the monkey brain. Despite advances in t ...
Print
Print

... hippocampus (188), as well as throughout the brain, where activation of CB1 by endocannabinoids can efficiently veto neurotransmitter release in many distinct types of synapses (see sect. IV). The conditions of synthesis, release, distance of diffusion, duration of effect, and site of action were al ...
Distinct Neuropathologic Phenotypes After Disrupting the
Distinct Neuropathologic Phenotypes After Disrupting the

... ClC-Kb, ClC-1, ClC-5, and ClC-7 that cause Bartter syndrome, myotonia congenita, Dent disease, and osteopetrosis, respectively (3Y6). ClC-6 and ClC-7 form a distinct branch of the CLC gene family, sharing 45% sequence homology (7). ClC-7 requires a A-subunit, Ostm1 (8); mutations in Ostm1 are respon ...
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Aging brain

Age is a major risk factor for most common neurodegenerative diseases, including Mild cognitive impairment, Alzheimer's disease, cerebrovascular disease, Parkinson's disease and Lou Gehrig's disease. While much research has focused on diseases of aging, there are few informative studies on the molecular biology of the aging brain (usually spelled ageing brain in British English) in the absence of neurodegenerative disease or the neuropsychological profile of healthy older adults. However, research does suggest that the aging process is associated with several structural, chemical, and functional changes in the brain as well as a host of neurocognitive changes. Recent reports in model organisms suggest that as organisms age, there are distinct changes in the expression of genes at the single neuron level. This page is devoted to reviewing the changes associated with healthy aging.
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