Chapter 7: Recent advances in enzyme technology
... enzyme-catalysed reactions. One major factor must first be addressed; the stability of the enzyme in these systems. A distinction should be drawn between the more water-soluble hydrophilic enzymes and the more hydrophobic enzymes often associated with lipid and membranes (e.g. lipases). The active i ...
... enzyme-catalysed reactions. One major factor must first be addressed; the stability of the enzyme in these systems. A distinction should be drawn between the more water-soluble hydrophilic enzymes and the more hydrophobic enzymes often associated with lipid and membranes (e.g. lipases). The active i ...
Pyrrolidine-2-carboxylic Acid (l
... This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research ...
... This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research ...
Highly Enantioselective Cyclocarbonylation of Allylic
... we chose to evaluate this ligand as it might meet the two primary requirements for achieving high enantioselectivity and activity in Pd-catalyzed cyclocarbonylation reactions: (1) conformational rigidity of Pd-bisphosphine complexes conducive to chiral induction and (2) a relatively flexible seven-m ...
... we chose to evaluate this ligand as it might meet the two primary requirements for achieving high enantioselectivity and activity in Pd-catalyzed cyclocarbonylation reactions: (1) conformational rigidity of Pd-bisphosphine complexes conducive to chiral induction and (2) a relatively flexible seven-m ...
Ch. 9 Review
... MASS-MASS PROBLEM) THE MEASURED AMOUNT OF A PRODUCT OBTAINED FROM A REACTION RATIO OF ACTUAL YIELD TO THE THEORETICAL YIELD, MULTIPLIED BY ...
... MASS-MASS PROBLEM) THE MEASURED AMOUNT OF A PRODUCT OBTAINED FROM A REACTION RATIO OF ACTUAL YIELD TO THE THEORETICAL YIELD, MULTIPLIED BY ...
Chem 263 April 11, 2006 Reductive Amination Amines can be
... Alkaloids are nitrogen-containing substances from plant sources. The study of alkaloids provided much of the growth in organic chemistry in the nineteenth century and remains today a fascinating area of research. Many alkaloids have pronounced biological properties, and many pharmaceutical agents us ...
... Alkaloids are nitrogen-containing substances from plant sources. The study of alkaloids provided much of the growth in organic chemistry in the nineteenth century and remains today a fascinating area of research. Many alkaloids have pronounced biological properties, and many pharmaceutical agents us ...
ch11 by dr. Dina
... PBr3 and SOCl2 These reagents only react with 1o and 2o alcohols in SN2 reactions ...
... PBr3 and SOCl2 These reagents only react with 1o and 2o alcohols in SN2 reactions ...
CH402 Asymmetric catalytic reactions Prof M. Wills
... Rh-diphosphine complexes control asymmetric induction by controlling the face of the alkene which attaches to the Rh. Hydrogen is transferred, in a stepwise manner, from the metal to the alkene. The intermediate complexes are diastereoisomers of different energy. ...
... Rh-diphosphine complexes control asymmetric induction by controlling the face of the alkene which attaches to the Rh. Hydrogen is transferred, in a stepwise manner, from the metal to the alkene. The intermediate complexes are diastereoisomers of different energy. ...
203 Medicinal Chemistry
... lant materials are used throughout developed and developing countries as home remedies, over the counter drug products and raw materials for the pharmaceutical industry. It is therefore essential to ensure the quality of medicinal plant products by using several techniques and applying suitable stan ...
... lant materials are used throughout developed and developing countries as home remedies, over the counter drug products and raw materials for the pharmaceutical industry. It is therefore essential to ensure the quality of medicinal plant products by using several techniques and applying suitable stan ...
Synthesis of Natural Products and Related Compounds using Enyne
... by deprotection of the Boc group. Hetero-Michael reaction of 65 gave the isoquinoline derivative 66, which was converted into dienyne 67. Since the tertiary amine of 67 coordinates to the ruthenium catalyst and the catalytic activity is decreased, 67 was converted into 67·HCl and dienyne metathesis ...
... by deprotection of the Boc group. Hetero-Michael reaction of 65 gave the isoquinoline derivative 66, which was converted into dienyne 67. Since the tertiary amine of 67 coordinates to the ruthenium catalyst and the catalytic activity is decreased, 67 was converted into 67·HCl and dienyne metathesis ...
CHE-310 Organic Chemistry I_
... For alkyl halides, alcohols and ethers, be able to name compounds correctly (nomenclature). Where necessay, be able to specify congiguration in the name. Know the two new mechanisms that we have learned in these chapters: SN2, SN1. Know which mechanisms go with which reactions under which conditions ...
... For alkyl halides, alcohols and ethers, be able to name compounds correctly (nomenclature). Where necessay, be able to specify congiguration in the name. Know the two new mechanisms that we have learned in these chapters: SN2, SN1. Know which mechanisms go with which reactions under which conditions ...
Synthesis of Amide Bond Isosteres Incorporated
... Lys264 posttranslationally hydroxylated and glycosylated with a β-D-galactopyranosyl residue (Figure 2).8 Four different groups of T cells could then be established based on the fine specificity for individual hydroxyl groups on the carbohydrate moiety.12 Truncation of the immunodominant epitope eve ...
... Lys264 posttranslationally hydroxylated and glycosylated with a β-D-galactopyranosyl residue (Figure 2).8 Four different groups of T cells could then be established based on the fine specificity for individual hydroxyl groups on the carbohydrate moiety.12 Truncation of the immunodominant epitope eve ...
A Floral Fragrance, Methyl Benzoate
... example cited the boiling point of the relatively nonpolar ester is only about 8°C higher than the boiling points of the polar acetic acid and 1-butanol, so a difficult separation problem exists if either starting material is increased in concentration and the product is isolated by distillation. An ...
... example cited the boiling point of the relatively nonpolar ester is only about 8°C higher than the boiling points of the polar acetic acid and 1-butanol, so a difficult separation problem exists if either starting material is increased in concentration and the product is isolated by distillation. An ...
Common aldehydes and ketones
... • A compound containing a carbonyl group (C=O) is normally in rapid equilibrium with an enol tautomer, which contains a pair of doubly bonded carbon atoms adjacent to a hydroxyl (−OH) group, C=C-OH. The keto form predominates at equilibrium for most ketones. Nonetheless, the enol form is important f ...
... • A compound containing a carbonyl group (C=O) is normally in rapid equilibrium with an enol tautomer, which contains a pair of doubly bonded carbon atoms adjacent to a hydroxyl (−OH) group, C=C-OH. The keto form predominates at equilibrium for most ketones. Nonetheless, the enol form is important f ...
Sodium Borohydride Reduction of Vanillin
... complex polymer that gives rigidity to trees and other woody plants. After cellulose, lignin is the second most abundant organic material on earth. Reduction Reactions In chemistry, reduction refers to the gain of electrons. This is usually manifested through the gain of hydrogen atoms or a loss of ...
... complex polymer that gives rigidity to trees and other woody plants. After cellulose, lignin is the second most abundant organic material on earth. Reduction Reactions In chemistry, reduction refers to the gain of electrons. This is usually manifested through the gain of hydrogen atoms or a loss of ...
The effect of confinement on chemical reactions
... information for the design of better catalytic materials, which can not only enhance the reaction yields but also provide a partial separation of the reaction products. During the past few years, we have carried out several studies on the effect of confinement on both equilibrium yields and reaction ...
... information for the design of better catalytic materials, which can not only enhance the reaction yields but also provide a partial separation of the reaction products. During the past few years, we have carried out several studies on the effect of confinement on both equilibrium yields and reaction ...
Rhenium(VII) Catalysis of Prins Cyclization Reactions
... more complex aldehyde 17, prepared by a metathesis reaction between crotonaldehyde and the corresponding terminal alkene, was noticeably slower than the others. All of the products showed very good selectivity for the equatorial alcohol THP products. Unsaturated aldehydes will be useful for forming ...
... more complex aldehyde 17, prepared by a metathesis reaction between crotonaldehyde and the corresponding terminal alkene, was noticeably slower than the others. All of the products showed very good selectivity for the equatorial alcohol THP products. Unsaturated aldehydes will be useful for forming ...
organic chemistry i
... Meso Structures Specification of configuration: more than one chiral center Conformational isomers ...
... Meso Structures Specification of configuration: more than one chiral center Conformational isomers ...
Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.