HONORS ORGANIC CHEM. HAHS MRS. RICHARDS 1 ORGANIC
... 4. At the end of the name, include the number indicating where the ___________________________ begins. 5. Enynes contain both an ______________ and an _______________. 6. To name an enyne, find the longest chain containing both functional groups and begin numbering this way: 7. When the double and t ...
... 4. At the end of the name, include the number indicating where the ___________________________ begins. 5. Enynes contain both an ______________ and an _______________. 6. To name an enyne, find the longest chain containing both functional groups and begin numbering this way: 7. When the double and t ...
Studies toward the Stereoselective Synthesis of the
... Mycotoxins are toxic secondary metabolites produced by fungi and they are the causative agents of various diseases in man and his domestic animals. Human beings and animals get the diseases, commonly called mycotoxicoses through the ingestion of foods or feeds contaminated by these toxic fungal meta ...
... Mycotoxins are toxic secondary metabolites produced by fungi and they are the causative agents of various diseases in man and his domestic animals. Human beings and animals get the diseases, commonly called mycotoxicoses through the ingestion of foods or feeds contaminated by these toxic fungal meta ...
Reaction of orthoesters with alcohols in the presence of acidic
... also. As O-acetylation with orthoester is not hitherto a known reaction, we were curious to explore this to find out whether such a transformation could be useful as a synthetic methodology and the results are summarized in Table I. Thus the reaction of alcohols and orthoester with various acid cata ...
... also. As O-acetylation with orthoester is not hitherto a known reaction, we were curious to explore this to find out whether such a transformation could be useful as a synthetic methodology and the results are summarized in Table I. Thus the reaction of alcohols and orthoester with various acid cata ...
A Mild and Convenient Conversion of Ketones to the Corresponding
... Reduction of Tosylhydrazones. General Procedure. The reduction of the tosylhydrazone of 6-oxo-15-hexadecenoicacid is representative. Benzoic acid (0.69 g, 5.67 mmol) was placed in a dried, nitrogen-flushed, 25-mL flask fitted with a septum inlet and magnetic stirring bar. Ethanol-free chloroform (5 ...
... Reduction of Tosylhydrazones. General Procedure. The reduction of the tosylhydrazone of 6-oxo-15-hexadecenoicacid is representative. Benzoic acid (0.69 g, 5.67 mmol) was placed in a dried, nitrogen-flushed, 25-mL flask fitted with a septum inlet and magnetic stirring bar. Ethanol-free chloroform (5 ...
SYNTHESIS OF NEW DICLOFENAC DERIVATIVES BY COUPLING WITH CHALCONE
... drugs and their behavior under the local moderately acidic or neutral condition of the stomach[3].The second mechanism which is considered as a key element in the NSAIDs-induced gastropathy is based on their generalized systemic action which follows their absorption and is related to their intrinsic ...
... drugs and their behavior under the local moderately acidic or neutral condition of the stomach[3].The second mechanism which is considered as a key element in the NSAIDs-induced gastropathy is based on their generalized systemic action which follows their absorption and is related to their intrinsic ...
Alcohols General formula R-OH hydroxyl group Nomenclature
... Note that all of the reactions are reversible. Therefore the alkene has to be removed from the solution as rapidly as it is formed. The slow rate-determining step is the formation of the carbocation. Tertiary alcohols react more rapidly than secondary which react more rapidly than primary. e.g. CH3 ...
... Note that all of the reactions are reversible. Therefore the alkene has to be removed from the solution as rapidly as it is formed. The slow rate-determining step is the formation of the carbocation. Tertiary alcohols react more rapidly than secondary which react more rapidly than primary. e.g. CH3 ...
Preparation of Alcohols
... F: Hydroxide attacks the less hindered carbon to give the trans diol. Carey 16.12-13. G: Alcohols are formed by the use of hydride reagents: LiAlH4, BH3. NaBH4 doesn't work (not reactive enough), even though BH3 does. Go figure. Carey Table 15.3. H: Two ways to do this, depending on which part of th ...
... F: Hydroxide attacks the less hindered carbon to give the trans diol. Carey 16.12-13. G: Alcohols are formed by the use of hydride reagents: LiAlH4, BH3. NaBH4 doesn't work (not reactive enough), even though BH3 does. Go figure. Carey Table 15.3. H: Two ways to do this, depending on which part of th ...
Enantiodivergent conversion of chiral secondary alcohols into
... •Summary (comparison to other methods) ...
... •Summary (comparison to other methods) ...
Ring-Opening Metathesis Polymerization of Norbornene Catalyzed
... Ru-carbene and Ru-vinylidene complexes have been proven to be highly efficient catalysts for a variety of olefin transformations. These include examples of ring-opening metathesis polymerization (ROMP) [1-7], ring-closing metathesis (RCM) [8,9], polycyclization reactions [9,10] and synthesis of natu ...
... Ru-carbene and Ru-vinylidene complexes have been proven to be highly efficient catalysts for a variety of olefin transformations. These include examples of ring-opening metathesis polymerization (ROMP) [1-7], ring-closing metathesis (RCM) [8,9], polycyclization reactions [9,10] and synthesis of natu ...
final1-final_report
... Fig. 1), have emerged as a new important family of ligands with interesting coordination characteristics, as shown by a large number of studies in the past few years and developing applications in catalysis. However, most of these systems are based on relatively simple pyridine ligands with no elabo ...
... Fig. 1), have emerged as a new important family of ligands with interesting coordination characteristics, as shown by a large number of studies in the past few years and developing applications in catalysis. However, most of these systems are based on relatively simple pyridine ligands with no elabo ...
resonance effects - HCC Learning Web
... The addition of bromine occurs in two steps In the first step the electrons act as a nucleophile ...
... The addition of bromine occurs in two steps In the first step the electrons act as a nucleophile ...
Reductive Couplings
... - can also use rhodium based catalysts [RuHCl(CO)(PPh3)] to affect similar transformations but an acid cocatalyst (m-NO2BzOH or CF3CO2H) is required when the alcohol is used as the substrate. ...
... - can also use rhodium based catalysts [RuHCl(CO)(PPh3)] to affect similar transformations but an acid cocatalyst (m-NO2BzOH or CF3CO2H) is required when the alcohol is used as the substrate. ...
© John Congleton, Orange Coast College Organic Chemistry 220
... What makes a good nucleophile? What makes a good base? What makes a good leaving group? What is meant by high and low polarizability? Allylic bromination Understand, be able to predict, and be able to complete mechanisms that involeve hydride and methyl shifts. During E1 and E2 reactions what will b ...
... What makes a good nucleophile? What makes a good base? What makes a good leaving group? What is meant by high and low polarizability? Allylic bromination Understand, be able to predict, and be able to complete mechanisms that involeve hydride and methyl shifts. During E1 and E2 reactions what will b ...
Organolithium reagent
... Organolithium reagents are industrially prepared by the reaction of an halocarbon with lithium metal, i.e. RÄX + 2 Li Å RÄLi + LiX.[1] A side reaction of this synthesis, especially with alkyl iodides, is the Wurtz reaction, in which an RÄLi species reacts with an RÄX species forming an R-R coupled p ...
... Organolithium reagents are industrially prepared by the reaction of an halocarbon with lithium metal, i.e. RÄX + 2 Li Å RÄLi + LiX.[1] A side reaction of this synthesis, especially with alkyl iodides, is the Wurtz reaction, in which an RÄLi species reacts with an RÄX species forming an R-R coupled p ...
Synthesis of hetero cyclic compounds pyrazole and pyridiazine from
... Hydrazide derivatives have been frequently found in heterocyclic chemistry as key intermediates for synthesis of hetero cyclic compound and they have been reported to exhibit biological activity[1].The hydrazide is still used in many fields of chemical and biological as anti-TB or Tuberculosis mater ...
... Hydrazide derivatives have been frequently found in heterocyclic chemistry as key intermediates for synthesis of hetero cyclic compound and they have been reported to exhibit biological activity[1].The hydrazide is still used in many fields of chemical and biological as anti-TB or Tuberculosis mater ...
Full Text - Iraqi National Journal of Chemistry
... Hydrazide derivatives have been frequently found in heterocyclic chemistry as key intermediates for synthesis of hetero cyclic compound and they have been reported to exhibit biological activity[1].The hydrazide is still used in many fields of chemical and biological as anti-TB or Tuberculosis mater ...
... Hydrazide derivatives have been frequently found in heterocyclic chemistry as key intermediates for synthesis of hetero cyclic compound and they have been reported to exhibit biological activity[1].The hydrazide is still used in many fields of chemical and biological as anti-TB or Tuberculosis mater ...
10. Alkyl Halides
... Reaction of an allylic bromide with base produces a conjugated diene, useful in synthesis of complex ...
... Reaction of an allylic bromide with base produces a conjugated diene, useful in synthesis of complex ...
Development of New Synthetic Routes to Organoboronates by Catalytic Allylic Substitution and
... for the organic transformation17-31 of aldehydes (2) affording homoallylic alcohols (3) (Scheme 1). This reaction is also a synthetic alternative to the aldol reaction31 since the homoallyl alcohol products can easily be converted to the corresponding aldol 4. Moreover, the alkene group may readily ...
... for the organic transformation17-31 of aldehydes (2) affording homoallylic alcohols (3) (Scheme 1). This reaction is also a synthetic alternative to the aldol reaction31 since the homoallyl alcohol products can easily be converted to the corresponding aldol 4. Moreover, the alkene group may readily ...
Copper-catalysed selective hydroamination reactions of alkynes Please share
... To assess the feasibility of the outlined alkyne hydroamination (Fig. 1b, A), we treated 1,2diphenylacetylene (1a) with N,N-dibenzyl-O-benzoylhydroxylamine (2a, 1.2 equiv.) and an excess of diethoxymethylsilane (3) in the presence of 2 mol % copper acetate and a range of phosphine ligands. A number ...
... To assess the feasibility of the outlined alkyne hydroamination (Fig. 1b, A), we treated 1,2diphenylacetylene (1a) with N,N-dibenzyl-O-benzoylhydroxylamine (2a, 1.2 equiv.) and an excess of diethoxymethylsilane (3) in the presence of 2 mol % copper acetate and a range of phosphine ligands. A number ...
Catalytic Enantioselective Dibromination of Allylic Alcohols
... the introduction of polar functionality capable of binding to the metal might lead to improvements in the reactivity, selectivity, and product utility. Indeed, cinnamyl alcohol (6) was converted to dibromide (−)-7 with 43% ee using (R,R)-TADDOL 8 (entry 3). Allylic ethers, amides, and sulfonamides w ...
... the introduction of polar functionality capable of binding to the metal might lead to improvements in the reactivity, selectivity, and product utility. Indeed, cinnamyl alcohol (6) was converted to dibromide (−)-7 with 43% ee using (R,R)-TADDOL 8 (entry 3). Allylic ethers, amides, and sulfonamides w ...
Syllabus - Chemistry
... acetylenes and aliphatic nitro compounds in organic synthesis. Two Group Disconnections Diels-Alder reaction. Examples from 1,3-dioxygenated systems (p-hydroxy carbonyl and 1,3 dicarbonyl compounds), a,b- unsaturated carbonyl compounds. Control in carbonyl condensation. 1,5-difunctionalised compound ...
... acetylenes and aliphatic nitro compounds in organic synthesis. Two Group Disconnections Diels-Alder reaction. Examples from 1,3-dioxygenated systems (p-hydroxy carbonyl and 1,3 dicarbonyl compounds), a,b- unsaturated carbonyl compounds. Control in carbonyl condensation. 1,5-difunctionalised compound ...
Suggested Problems for Chapter 1
... 7. (12 pts.) An unknown compound A (molecular formula C7H14O) was treated with NaBH4 in CH3OH to form compound B (molecular formula C7H16O). Compound A has a strong absorption in its IR spectrum at 1716 cm-1. Compound B has strong absorption in its IR spectrum at 3200-3600 cm-1. The 1H NMR spectra ...
... 7. (12 pts.) An unknown compound A (molecular formula C7H14O) was treated with NaBH4 in CH3OH to form compound B (molecular formula C7H16O). Compound A has a strong absorption in its IR spectrum at 1716 cm-1. Compound B has strong absorption in its IR spectrum at 3200-3600 cm-1. The 1H NMR spectra ...
Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.