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OrganicChemistryforAPlecture2010StudentVersioncompatibility
OrganicChemistryforAPlecture2010StudentVersioncompatibility

... Cis and Trans Isomers • Alkenes exhibit not only structural isomerism but geometric (cis-trans) isomerism as well. In geometric isomers the bonds are the same, but the molecules have different geometries. Geometric isomerism is possible in alkenes because rotation about the C=C double bond is ...
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Organic Chemistry = the study of carbon and most carbon compounds
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Organic Chemistry - Centennial College Libraries
Organic Chemistry - Centennial College Libraries

... Carboxylic acids are compounds that contain the carboxyl group –COOH. Esters are compounds that contain –COO – between two alkyl groups. They are formed from a carboxylic acid and an alcohol. Amides are compounds that contain the H2NCOO— group. They are formed from ammonia and carboxylic ...
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Chemistry 250A -- Exam #3 Answer Key -

... hydrogen in this orientation and therefore elimination proceeds to give only the product shown. By contrast, the second reaction proceeds via an E1 mechanism as shown below. (The absence of a strong base makes the E2 mechanism unfavorable.) In the E1 mechanism the leaving group leaves first, produci ...
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Strychnine total synthesis



Strychnine total synthesis in chemistry describes the total synthesis of the complex biomolecule strychnine. The first reported method by the group of Robert Burns Woodward in 1954 is considered a classic in this research field. At the time it formed the natural conclusion to an elaborate process of molecular structure elucidation that started with the isolation of strychnine from the beans of Strychnos ignatii by Pierre Joseph Pelletier and Joseph Bienaimé Caventou in 1818. Major contributors to the entire effort were Sir Robert Robinson with over 250 publications and Hermann Leuchs with another 125 papers in a time span of 40 years. Robinson was awarded the Nobel Prize in Chemistry in 1947 for his work on alkaloids, strychnine included. The process of chemical identification was completed with publications in 1946 by Robinson and later confirmed by Woodward in 1947. X-ray structures establishing the absolute configuration became available between 1947 and 1951 with publications from J. M. Bijvoet and J.H. Robertson .Woodward published a very brief account on the strychnine synthesis in 1954 (just 3 pages) and a lengthy one (42 pages) in 1963.Many more methods exist and reported by the research groups of Magnus, Overman, Kuehne, Rawal, Bosch, Vollhardt, Mori, Shibasaki, Li, Fukuyama Vanderwal and MacMillan. Synthetic (+)-strychnine is also known. Racemic synthesises were published by Padwa in 2007 and in 2010 by Andrade and by Reissig.In his 1963 publication Woodward quoted Sir Robert Robinson who said for its molecular size it is the most complex substance known.
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