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PP - Columbia University
PP - Columbia University

... • So when calulating Go, instead of writing in “55” when water participates in a reaction (e.g., a hydrolysis) we write “1.” • This is not cheating; we are in charge of what is a “standard” condition, and we all agree to this: 55 M H20 is unit (“1”) concentration for the purpose of defining Go. ...
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... For the following reactions write a net ionic equation. Box your final answer. 1. Carbon disulfide vapor is burned in excess oxygen. a. What would be the products if the oxygen gas was not in excess? 2. Potassium permanganate solution is added to an acidic solution of hydrogen peroxide. a. This reac ...
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... A polyester may be formed by the reaction of a dicarboxylic acid and a diol. The reactants are heated together at temperatures up to 180oC, often in the presence of a titanium-containing catalyst. Water is released during the reaction. If the methyl ester of the dicarboxylic acid is used, there is l ...
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Strychnine total synthesis



Strychnine total synthesis in chemistry describes the total synthesis of the complex biomolecule strychnine. The first reported method by the group of Robert Burns Woodward in 1954 is considered a classic in this research field. At the time it formed the natural conclusion to an elaborate process of molecular structure elucidation that started with the isolation of strychnine from the beans of Strychnos ignatii by Pierre Joseph Pelletier and Joseph Bienaimé Caventou in 1818. Major contributors to the entire effort were Sir Robert Robinson with over 250 publications and Hermann Leuchs with another 125 papers in a time span of 40 years. Robinson was awarded the Nobel Prize in Chemistry in 1947 for his work on alkaloids, strychnine included. The process of chemical identification was completed with publications in 1946 by Robinson and later confirmed by Woodward in 1947. X-ray structures establishing the absolute configuration became available between 1947 and 1951 with publications from J. M. Bijvoet and J.H. Robertson .Woodward published a very brief account on the strychnine synthesis in 1954 (just 3 pages) and a lengthy one (42 pages) in 1963.Many more methods exist and reported by the research groups of Magnus, Overman, Kuehne, Rawal, Bosch, Vollhardt, Mori, Shibasaki, Li, Fukuyama Vanderwal and MacMillan. Synthetic (+)-strychnine is also known. Racemic synthesises were published by Padwa in 2007 and in 2010 by Andrade and by Reissig.In his 1963 publication Woodward quoted Sir Robert Robinson who said for its molecular size it is the most complex substance known.
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