Ecstasy - IrishHealth
... Ecstasy is usually taken at ‘raves’ or at discos to produce a feeling of relaxation with increased energy, happiness and flexibility. Someone using Ecstasy may feel less inhibited, experience everything more intensely, feel mellow and calm. It can bring a sense of vulnerability. Ecstasy takes effect ...
... Ecstasy is usually taken at ‘raves’ or at discos to produce a feeling of relaxation with increased energy, happiness and flexibility. Someone using Ecstasy may feel less inhibited, experience everything more intensely, feel mellow and calm. It can bring a sense of vulnerability. Ecstasy takes effect ...
Ethnopharmacology Handout
... Adverse effects occur at much lower dosages. There have been few ethno-pharmacologic studies on SSRIs so it is not possible to state if they are tolerated better than SSRIs in people of Asian ancestry. Lithium Non whites require lower doses and report more lethargy and dizziness (even when blood l ...
... Adverse effects occur at much lower dosages. There have been few ethno-pharmacologic studies on SSRIs so it is not possible to state if they are tolerated better than SSRIs in people of Asian ancestry. Lithium Non whites require lower doses and report more lethargy and dizziness (even when blood l ...
Drugs in Perspective
... -During the Civil War many soldiers became addicted to morphine (soldier’s disease) -In the late 1800s a semisynthetic drug “nonaddicting” wonder drug was developed to relieve pain and replace morphine. It was called heroin. ...
... -During the Civil War many soldiers became addicted to morphine (soldier’s disease) -In the late 1800s a semisynthetic drug “nonaddicting” wonder drug was developed to relieve pain and replace morphine. It was called heroin. ...
Illegal Drugs - Henry County Schools
... testosterone and decreases sperm production • Females – stillbirths, low birth weight and conditions similar to FAS • Damaging to respiratory system • Psychological ...
... testosterone and decreases sperm production • Females – stillbirths, low birth weight and conditions similar to FAS • Damaging to respiratory system • Psychological ...
Pharmacology: The Study of Drugs
... – Chemically changed into compounds that are less effective and more water soluble – occurs primarily in the liver but also in the lungs, kidneys, GI or skin. – Conditions that alter these sites may alter the elimination of the drug ...
... – Chemically changed into compounds that are less effective and more water soluble – occurs primarily in the liver but also in the lungs, kidneys, GI or skin. – Conditions that alter these sites may alter the elimination of the drug ...
General Issues
... 2. Rank those sources based on how fast they reach blood & thus the brain 3. List the factors that determine the effect of a drug on an individual. (In other words, what makes a psychoactive drug be more effective in one person than another) ...
... 2. Rank those sources based on how fast they reach blood & thus the brain 3. List the factors that determine the effect of a drug on an individual. (In other words, what makes a psychoactive drug be more effective in one person than another) ...
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... Timing of Drug Effects: • Onset- time from when a drug is given to when its effects first occur • Peak Effect- when a drug is at its maximum effect • Duration- time from when drug effects begin to when they stop ...
... Timing of Drug Effects: • Onset- time from when a drug is given to when its effects first occur • Peak Effect- when a drug is at its maximum effect • Duration- time from when drug effects begin to when they stop ...
Remediation Pharmacology Unit Exam Name: Score:____/75 Which
... III. Rapid onset of drug IV. Dose estimation is difficult A. B. ...
... III. Rapid onset of drug IV. Dose estimation is difficult A. B. ...
MEDcounselor
... • Search by marking/imprint, shape and/or color • Results include product descriptions, as well as full-color drug images, to ensure the right drug is being taken to treat the right medical condition ...
... • Search by marking/imprint, shape and/or color • Results include product descriptions, as well as full-color drug images, to ensure the right drug is being taken to treat the right medical condition ...
File chemical comp. in cells notes 8a
... found in the cell walls of plants is a type of carbohydrate Lipids – are energy-rich organic compounds made of C, H and O – fats, oils and waxes are all lipids Lipids contain even more energy than carbohydrates! Cells store energy in lipids for late use What do a bird’s feathers, a spider’s web and ...
... found in the cell walls of plants is a type of carbohydrate Lipids – are energy-rich organic compounds made of C, H and O – fats, oils and waxes are all lipids Lipids contain even more energy than carbohydrates! Cells store energy in lipids for late use What do a bird’s feathers, a spider’s web and ...
Executive Summary - BioTech Showcase News
... Since the drugs do not precipitate withdrawal, they offer very promising use for addiction therapy as a preferred substitute for methadone and Suboxone, as well as for pain. The drugs are orally active and inexpensive to manufacture using PPL's manufacturing process. Key patents were issued in the U ...
... Since the drugs do not precipitate withdrawal, they offer very promising use for addiction therapy as a preferred substitute for methadone and Suboxone, as well as for pain. The drugs are orally active and inexpensive to manufacture using PPL's manufacturing process. Key patents were issued in the U ...
Case Study #1 Use of bioinformatics in drug development
... often exceed the corresponding substrate affinities by several orders of magnitude! •Agonists are analogous to enzyme substrates: part of the binding energy may be used for signal transduction, inducing a ...
... often exceed the corresponding substrate affinities by several orders of magnitude! •Agonists are analogous to enzyme substrates: part of the binding energy may be used for signal transduction, inducing a ...
GENERAL CHEMISTRY
... 3. to acquire knowledge concerning the structure and properties of particular groups of chemical compounds ...
... 3. to acquire knowledge concerning the structure and properties of particular groups of chemical compounds ...
Discovery of Novel Phosphonate Natural Products Joel P. Cioni1
... Phosphonic and phosphinic acid natural products present a group of reduced phosphoruscontaining compounds with potent and diverse biological activities that have found widespread use in both medicine and industry. At a time when the discovery of novel therapeutics is challenged to keep pace with the ...
... Phosphonic and phosphinic acid natural products present a group of reduced phosphoruscontaining compounds with potent and diverse biological activities that have found widespread use in both medicine and industry. At a time when the discovery of novel therapeutics is challenged to keep pace with the ...
Pharmaceutical Technology
... the solubility of such drugs in water, the latter’s polarity should be lowered. This can be achieved by adding a third component such as a water-miscible organic liquid with a low polarity. Such a liquid, when used in this context, is called a co-solvent. Typically, a linear increase in co-solvent f ...
... the solubility of such drugs in water, the latter’s polarity should be lowered. This can be achieved by adding a third component such as a water-miscible organic liquid with a low polarity. Such a liquid, when used in this context, is called a co-solvent. Typically, a linear increase in co-solvent f ...
2. Basic Pharmacology
... exhibit affinity for the receptor do not have intrinsic activity at the receptor competitive antagonist: binds to the receptor in a reversible mass-action manner -agonists given in high concentrations can displace the antagonist from the receptor -agonist can then produce its effect ...
... exhibit affinity for the receptor do not have intrinsic activity at the receptor competitive antagonist: binds to the receptor in a reversible mass-action manner -agonists given in high concentrations can displace the antagonist from the receptor -agonist can then produce its effect ...
Design and Synthesis of Small Molecule Inhibitors of
... negatively correlated with levels of HDL-cholesterol in vivo. Disruption of EL activity, either through antibody directed inhibition, or gene knock-out, has been shown to increase levels of HDL-C in rabbits and mice on both normal and high-fat diets. Because the active site of EL contains serine-pro ...
... negatively correlated with levels of HDL-cholesterol in vivo. Disruption of EL activity, either through antibody directed inhibition, or gene knock-out, has been shown to increase levels of HDL-C in rabbits and mice on both normal and high-fat diets. Because the active site of EL contains serine-pro ...
Psychopharmacology Dr. Sujit Kumar kar
... • Used in many psychiatric disorders other than Depression. • Full clinical response in 6-8 weeks in major depression, up to 6/12 in obsessive compulsive disorder. ...
... • Used in many psychiatric disorders other than Depression. • Full clinical response in 6-8 weeks in major depression, up to 6/12 in obsessive compulsive disorder. ...
Drugs
... The Effects Drugs have on the Body are Determined by: The way the drug enters the body. Weight, Age, The amount taken Health Status Emotional State the Dose. Use of other The ability of a Drugs substance to dissolve soluability. ...
... The Effects Drugs have on the Body are Determined by: The way the drug enters the body. Weight, Age, The amount taken Health Status Emotional State the Dose. Use of other The ability of a Drugs substance to dissolve soluability. ...
6 N-Acetyltransferase Activity
... often genetically determined Study of genetically determined variations that are revealed solely by the effects of drugs Pharmacogenetics is now used to describe the influence of genes on the efficacy and side effects of drugs ...
... often genetically determined Study of genetically determined variations that are revealed solely by the effects of drugs Pharmacogenetics is now used to describe the influence of genes on the efficacy and side effects of drugs ...
Psych 260
... (With the exception of the last question, each question is worth 1 pt. Write your answers for the last questions directly on the quiz, and hand it in along with your scantron. Be sure to put your name on both the scantron and your quiz!) 1. ___________ refers to the process by which drugs are absorb ...
... (With the exception of the last question, each question is worth 1 pt. Write your answers for the last questions directly on the quiz, and hand it in along with your scantron. Be sure to put your name on both the scantron and your quiz!) 1. ___________ refers to the process by which drugs are absorb ...
Proposed draft Phenolic compounds with anti
... Key words: anti-virulence, quorum quenching, natural products, antibacterial resistance, phenolic compounds. Natural products represent the major source of approved drugs and still play an important role in supplying chemical diversity as well as new structures for designing more efficient antimicro ...
... Key words: anti-virulence, quorum quenching, natural products, antibacterial resistance, phenolic compounds. Natural products represent the major source of approved drugs and still play an important role in supplying chemical diversity as well as new structures for designing more efficient antimicro ...
Supplementary Materials and Methods
... We used the Drugs@FDA database (downloaded on March 19, 2014), which lists all regulatory actions by the US Food and Drug Administration (FDA), to determine the number of new drug approvals by year. A new drug approval was defined as the first approval of a new drug application (NDA) for a new molec ...
... We used the Drugs@FDA database (downloaded on March 19, 2014), which lists all regulatory actions by the US Food and Drug Administration (FDA), to determine the number of new drug approvals by year. A new drug approval was defined as the first approval of a new drug application (NDA) for a new molec ...
English - 3-Medicine%28mpz%20edit%29
... Aspirin In 1890, salicylic acid was being manufactured as a cheap and effective inflammation reliever for rheumatoid arthritis, despite its unpleasant side effects (nausea, gastric catarrh). Acetylsalicylic acid (or aspirin) was synthesized in 1897 by the German chemist Felix Hoffmann at Bayer and t ...
... Aspirin In 1890, salicylic acid was being manufactured as a cheap and effective inflammation reliever for rheumatoid arthritis, despite its unpleasant side effects (nausea, gastric catarrh). Acetylsalicylic acid (or aspirin) was synthesized in 1897 by the German chemist Felix Hoffmann at Bayer and t ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.