Drug Discovery and Development
... • Choose a disease • Choose a drug target • Do a “bioassay” bioassay = A test used to determine biological activity. • Find a “lead compound” “lead compound” = structure that has some activity against the chosen target, but not yet good enough to be the drug itself. • If not known, determine the s ...
... • Choose a disease • Choose a drug target • Do a “bioassay” bioassay = A test used to determine biological activity. • Find a “lead compound” “lead compound” = structure that has some activity against the chosen target, but not yet good enough to be the drug itself. • If not known, determine the s ...
1. An introduction to drugs, their action and discovery
... • Side effect – unwanted effect usually; however, they are not always non-beneficial • For example, the drowsiness side effect of anti-histamine may help sleep. ...
... • Side effect – unwanted effect usually; however, they are not always non-beneficial • For example, the drowsiness side effect of anti-histamine may help sleep. ...
Synthetic Chemistry and Medicine
... relate it to applied synthetic chemistry • Medicinal chemistry—a definition—the use of synthetic organic chemistry to create molecules that will alter in a useful way some disease process in a living system. -D. Lednicer ...
... relate it to applied synthetic chemistry • Medicinal chemistry—a definition—the use of synthetic organic chemistry to create molecules that will alter in a useful way some disease process in a living system. -D. Lednicer ...
AOE – The Institute of Molecular Technology for Drug Discovery and
... AOE – The Institute of Molecular Technology for Drug Discovery and Synthesis The Institute of Molecular Technology for Drug Discovery and Synthesis (IMT) has led Hong Kong to become a leading research center for drug discovery and synthesis, specialized in Metal-Based Drugs and natural products from ...
... AOE – The Institute of Molecular Technology for Drug Discovery and Synthesis The Institute of Molecular Technology for Drug Discovery and Synthesis (IMT) has led Hong Kong to become a leading research center for drug discovery and synthesis, specialized in Metal-Based Drugs and natural products from ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
... 1. Give a brief note on subchronic toxicity. 2. Discuss the metabolism of Theophylline. 3. “Adjustments in Cardio active drug therapy is difficult”. Justify. 4. What do you mean by “Low Therapeutic Index”? Give examples. 5. When does a drug is said to have a high benefit to harm ratio? 6. How will y ...
... 1. Give a brief note on subchronic toxicity. 2. Discuss the metabolism of Theophylline. 3. “Adjustments in Cardio active drug therapy is difficult”. Justify. 4. What do you mean by “Low Therapeutic Index”? Give examples. 5. When does a drug is said to have a high benefit to harm ratio? 6. How will y ...
Flyer: Harvesting Natural Products for novel drug leads
... There is now a pressing need to derive novel antibiotics to deal with the multiply antibiotic resistant stains that now represent significant clinical threats. The Aberystwyth Natural Products Grouping is responding to this challenge by mining relatively unexplored part of the natural world for nove ...
... There is now a pressing need to derive novel antibiotics to deal with the multiply antibiotic resistant stains that now represent significant clinical threats. The Aberystwyth Natural Products Grouping is responding to this challenge by mining relatively unexplored part of the natural world for nove ...
Headline Text 28 Point Color Text 2
... How molecular motors work Computer modeling in support of chemical and drug design • Polymer delivery systems • Catalysts • Small molecule drugs ...
... How molecular motors work Computer modeling in support of chemical and drug design • Polymer delivery systems • Catalysts • Small molecule drugs ...
Principles of Pharmacolgy
... Study of actions of the drug & changes that drugs undergo from absorption to excretion Receptor, Agonist, Antagonist propranolol (Inderal) beta adrenergic antagonist ...
... Study of actions of the drug & changes that drugs undergo from absorption to excretion Receptor, Agonist, Antagonist propranolol (Inderal) beta adrenergic antagonist ...
Slide 1
... An academic partner with the unique know-how and key expertise that is essential for the successful progression of a drug target. You are a researcher who wants to see their innovative ideas turned into a medicine. What are we looking for? 1. A coherent therapeutic hypothesis based on sound understa ...
... An academic partner with the unique know-how and key expertise that is essential for the successful progression of a drug target. You are a researcher who wants to see their innovative ideas turned into a medicine. What are we looking for? 1. A coherent therapeutic hypothesis based on sound understa ...
Soft Drug
... • Rational drug design is a more focussed approach, which uses information about the structure of a drug receptor or one of its natural ligands to identify or create candidate drugs. • The three-dimensional structure of a protein can be determined using methods such as X-ray crystallography or nucl ...
... • Rational drug design is a more focussed approach, which uses information about the structure of a drug receptor or one of its natural ligands to identify or create candidate drugs. • The three-dimensional structure of a protein can be determined using methods such as X-ray crystallography or nucl ...
Virtual Screening in Drug Discovery: an Overview
... • It takes > 10 years and > 1 billion dollars of investment to develop a new drug •Molecular modeling tools has been widely used in drug development projects to help reduce the time/cost in early stages of drug discovery. ...
... • It takes > 10 years and > 1 billion dollars of investment to develop a new drug •Molecular modeling tools has been widely used in drug development projects to help reduce the time/cost in early stages of drug discovery. ...
The Drug Discovery Process
... Develop an assay to evaluate activity of compounds on the target - in vitro (e.g. enzyme assay) - in vivo (animal model or pharmacodynamic assay) ...
... Develop an assay to evaluate activity of compounds on the target - in vitro (e.g. enzyme assay) - in vivo (animal model or pharmacodynamic assay) ...
Lum, 2004
... novel drug activities to be uncovered in a systematic and unbiased fashion Biological processes that are affected by a given compound are identified in addition to the precise protein target(s) ...
... novel drug activities to be uncovered in a systematic and unbiased fashion Biological processes that are affected by a given compound are identified in addition to the precise protein target(s) ...
第一章 绪论
... bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage. In pharmacology, a drug is defined as "a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used t ...
... bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage. In pharmacology, a drug is defined as "a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used t ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.