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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034 M.Sc. DEGREE EXAMINATION – BIOMED.INSTRUMENTATION SC. TM 09 SECOND SEMESTER – APRIL 2007 BI 2952 - THERAPEUTIC DRUG MONITORING Date & Time: 24/04/2007 / 1:00 - 4:00 PART A Answer all Dept. No. Max. : 100 Marks 10X2=20 1. Give a brief note on subchronic toxicity. 2. Discuss the metabolism of Theophylline. 3. “Adjustments in Cardio active drug therapy is difficult”. Justify. 4. What do you mean by “Low Therapeutic Index”? Give examples. 5. When does a drug is said to have a high benefit to harm ratio? 6. How will you solve the pharmacokinetic problem of poor absorption of a particular drug prescribed? 7. What are Xenobiotics? 8. Define absorption of drugs. What factors determine drug absorption in the body? 9. List out the factors that determine the drug penetration rate in the CSF? 10. What does CYP1A2 indicate? PART B Answer any four 4X10=40 11. Describe phase I mechanism of detoxification in human body. 12. What are analgesics? Explain the methodology to monitor analgesics in patients’ plasma. 13. Discuss the process of distribution of drugs in human system. 14. Report on acute poisoning and add a note on the organizational consideration of poisoning cases screening laboratories. 15. Outline the classification of drug of abuse with suitable examples. 16. “Studies on Human must be conducted in 3 phases before the FDA approves a new drug for marketing”. Substatiate. PART C Answer any two 2X20=40 17. What are anticonvulsants? Describe in detail the methodology followed to monitor a patient under Carbamazepine therapy. 18. Discuss in detail the bioavailability and the process of distribution of drugs. 19. (a) Explain carcinogenic effect of drugs. (b) Discuss the pharmacology of poisons and give the screening test for ‘Alcohol’. 20. Define the reliability criteria of an analytical method? Write a detailed note on calibration and control materials used for Quality control purposes. ***** 1