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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034 M.Sc. DEGREE EXAMINATION – BIOMED.INSTRUMENTATION SC. FIRST SEMESTER – NOVEMBER 2007 AG 2 BI 1801 - CLINICAL BIOCHEMISTRY Date : 27/10/2007 Time : 1:00 - 4:00 Dept. No. Max. : 100 Marks Answer all PART A 10X2=20 1. List out the precautions to be followed while handling chemicals in a clinical lab 2. Give the nutritional classification of amino acids with examples. 3. What is histotoxic hypoxia? 4. Explain osmolarity. 5. Give the significance of phosphate buffer system. 6. Comment on isoelectric point. 7. Classify hormones based on their chemistry. 8. What are porphyrins? 9. Give the normal value of T3 and T4. 10. Differentiate coenzymes and prosthetic groups. PART B Answer any four 4X10=40 11. Discuss the role of serum enzymes in liver diseases. 12. Describe the mechanism of hormonal action. Add a note on hormone receptors. 13. Explain any two diseases that commonly occur in newborn. 14. Write a detailed note on the inherited disorders of amino acid metabolism. 15. (a) What are the two components of inflammation? (b) What are the factors responsible for dissociation of oxyhemoglobin? 16.Explain the fractional gastric analysis using test meals. PART C Answer any two 2X20=40 17. The balance of all the salts in our body is crucial for a wide array of activities”. Justify. 18. Describe in detail the endocrine functions of pancreas. 19. Give the dietary source, physiological function and deficiency disorders of vitamins 20. (a) Explain the transport of Carbon dioxide within the body. (b) Discuss the role of bicarbonate buffer system in the ECF. ************