Download Proposed draft Phenolic compounds with anti

Proposed draft
Phenolic compounds with anti-virulence properties
Israel Castillo-Juárez1*., Rodolfo García-Contreras2., Macrina Pérez López1 and Naybi MuñozCazares1.
1. Department of Botany, Colegio de Postgraduados.
2. Department of Microbiology and Parasitology, Facultad de medicina UNAM.
*corresponding author
Key words: anti-virulence, quorum quenching, natural products, antibacterial resistance, phenolic
compounds.
Natural products represent the major source of approved drugs and still play an important
role in supplying chemical diversity as well as new structures for designing more efficient
antimicrobials (Castillo-Juárez et al., 2013). They are also the basis for the discovery of new
mechanisms of antibacterial action. In this regard, a large number of substances, mainly extracts
from natural sources, have been obtained in order to identify their anti-virulence activity (MartínRodríguez et al., 2016; Soo et al., 2016). In recent years an increase in the study of anti-virulence
natural product derivatives is occurring. Different targets have been proposed as a solution to the
serious problem of bacterial antibiotic resistance. Inhibition of bacterial quorum sensing systems
has been one of the most studied, however, there are other mechanisms involved in virulence
regulation, damage to the host and bacterial survival, which suggests that there are another good
targets such as bacterial secretion systems, adhesion molecules, two-component systems, response
regulators, key enzymes, evasion of host defense systems etc. (Castillo-Juárez et al., 2015; Montes
de Oca-Mejía et al., 2016). An important feature of the anti-virulence molecules is that they may be
less prone to generate the emergence of resistance than conventional antibiotics (Rangel-Vega et
al., 2015). By far, phenolics represent the highest number of active compounds reported in terms
of anti-virulence effects when compared to all other classes of natural products. In the next proposal
we analyze and discuss recent advances in the field of phenols anti-virulence, focusing on the
structure-activity relationship of metabolites derived from natural products.
Introduction
1.-Challenges in fighting bacterial infections in the post-antibiotic era.
1.1.- Anti-virulence and natural products
1.2.- Virulence targets (quorum sensing systems-global virulence regulator, biofilms, secretion
system, pili/fimbriae, two-component system, exotoxins and persister cells).
2.1.- Phenolic compounds anti-virulence
2.2.- Phenylpropenoids
2.3.-Benzoic acid derivatives
2.4.- Tannins
2.5.-Stilbenes and flavonoids
2.6.- Diarylheptanoids
3.- Conclusion and future perspective
References
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