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Signal Transduction pt 1
Signal Transduction pt 1

... subcellular proteins and a cellular response to insulin  Different receptors recognize different chemical messengers, which can be peptides, small chemicals or proteins, in a specific one-to-one relationship ...
ACh - Perkins Science
ACh - Perkins Science

... • Electrical synapses occur in smooth muscle and cardiac muscle, between some neurons of the brain, and between glial cells. • Stimulation causes phosphorylation or dephosphorylation of connexin proteins to open or close the channels ...
Name
Name

... _____ 1. Sensory receptors found in the skin, which are specialized to detect temperature, pressure changes and pain. _____ 2. Specialized cells that myelinate the fibers of neurons found in the PNS _____ 3. Junction or point of close contact between neurons. _____ 4. Bundle of nerve processes insid ...
Synthesis and degradation of neurotransmitters
Synthesis and degradation of neurotransmitters

... • Appr. 50 known • Mainly in the hypothalamic-pituitary system • Synthesis: prepropeptid → ER, signal sequence cleavage → propeptid in vesicles → further processing → peptide neurotransmitter (1 or more) • Removal from synaptic cleft: Degradation, but not re-uptake ...
What is resting membrane potential, how is it created and maintained?
What is resting membrane potential, how is it created and maintained?

... across a synapse ...
fleming_Oct
fleming_Oct

... Excitatory paths are shown in green; inhibitory are in red. The substantia nigra’s axons inhibit the putamen. Axon loss increases excitatory communication to the globus pallidus. The result is increased inhibition from the globus pallidus to the thalamus and decreased excitation from the thalamus to ...
Drugs Change the way Neurons communicate
Drugs Change the way Neurons communicate

... • Alcohol binds to GABA receptors on the dendrites of neurons which release GABA as their neurotransmitter. • Alcohol is an inhibitory signal (CNS depressant) so it reduces the activity of the presynaptic neuron (which releases GABA as its neurotransmitter). • The presynaptic neuron will release les ...
Synaptic Transmission - Grand Haven Area Public Schools
Synaptic Transmission - Grand Haven Area Public Schools

... • Plays a dual role in sleep: day – excites the brain, night – slows down the brain. • Huntington’s disease involves loss of neurons in striatum that utilize GABA – Symptoms: • jerky involuntary movements ...
Drugs Hanson 4
Drugs Hanson 4

... System (continued) • Hormones are secreted into the bloodstream and carried by the blood to all the organs and tissues of the body. • Hormones affect selected tissues that are designed to receive the information. • Hormones may be highly selective or very general with regard to the cells or organs ...
Peripheral Nervous System - e
Peripheral Nervous System - e

...  Swollen ends containing many vesicles ...
Cell Signaling Mechanisms
Cell Signaling Mechanisms

...  The intracellular domain then interacts with other intracellular signaling proteins  These intracellular signaling proteins further relay the message to one or more effector proteins  Effector proteins mediate the appropriate response ...
1.nerve notes
1.nerve notes

... Synapse – open space between two neurons ...
Document
Document

... • Perception: the conscious interpretation of those stimuli Sensory Integration • Input comes from exteroceptors, proprioceptors, and interoceptors • Input is relayed toward the head, but is processed along the way Sensory Integration • Levels of neural integration in sensory systems: 1. Receptor le ...
Ch 13 - lanoue
Ch 13 - lanoue

... thumb and index finger. The distance the ruler falls before he/she stops it with his thumb and finger indicates their reaction time. Repeat twice. Record the results. Challenge: Try the experiment again while the catcher recites addition or multiplication facts. Compare the results. What happened to ...
Sensory Organs and Processes, Part II
Sensory Organs and Processes, Part II

... Others have a centralized nervous system (brain) ...
The Nervous System
The Nervous System

... Parkinson’s Disease – affects nerve cells, or neurons, in a part of the brain that controls muscle movement. Neurons that make a chemical called dopamine die or do not work properly. Dopamine normally sends signals that help coordinate your movements. No one knows what damages these cells. Symptoms ...
Biological Basis for Understanding Psychotropic Drugs
Biological Basis for Understanding Psychotropic Drugs

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11 Signal Transduction
11 Signal Transduction

... • Each TK adds a phosphate from an ATP to a tyrosine on the tail of the other polypeptide • The receptor is fully activated as a result ...
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... Neural networks in relay nuclei integrate sensory information from multiple receptors. A. Sensory information is transmitted in the central nervous system through hierarchical processing networks. A stimulus to the skin is registered by a large group of postsynaptic neurons in relay nuclei in the br ...
Chemical Senses
Chemical Senses

... The 3-D model shown on the right (from Couto & Dickson, 2005) is that of a fly antennal lobe (AL), the equivalent of the vertebrate olfactory bulb. As you can see, the AL is composed of spheroidal structures, the glomeruli. While vertebrate olfactory bulbs may contain thousands of glomeruli, th ...
Biochemistry of Nerve Transmission - I-GaP
Biochemistry of Nerve Transmission - I-GaP

... Neurotransmitter Receptors Once the molecules of neurotransmitter are released from a cell as the result of the firing of an action potential, they bind to specific receptors on the surface of the postsynaptic cell. In all cases in which these receptors have been cloned and characterized in detail, ...
Key Transmitters - Sinauer Associates
Key Transmitters - Sinauer Associates

... current to pass when the neuron is simultaneously depolarized by, for example, highfrequency activation of AMPA channels, ongoing action potential activity, or co-activation of metabotropic glutamate receptors (see below). The consequent entry of Ca2+ ions then induces a variety of downstream effect ...
CNS Introduction
CNS Introduction

... -Role in nociception, schizophrenia, depression, eating disorders, temp. regulation ...
The Nervous Systeminofnotes
The Nervous Systeminofnotes

... • Receives information • Responds to information • Maintains homeostasis ...
Neuronal signaling and synapses
Neuronal signaling and synapses

... -four main types of changes can occur with the activation of metabotropic receptors -opening specific ion channels through the postsynaptic cell member – e.g. opening of a potassium channel (prolonged opening) -activation of cAMP or cGMP in the neuron can activate metabolic processes that result in ...
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Endocannabinoid system

The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as ""endocannabinoids"" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems.The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized form the endocannabinoid system.The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.
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