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11- neurotransmitters and receptors
11- neurotransmitters and receptors

... phenylalanine. No whole protein; source of all aa’s minus this one. At least through to adulthood, while nervous ...
Lipid rafts
Lipid rafts

... – regulation of adipocyte differentiation – regulation of lipid anabolism: in the adipose tissue, they regulate the expression of LPL, FATP… PPARγ are targeted by anti-diabetic substances of the thiazolidinedione class (glitazones, e.g. rosiglitazone) that enhance the tissue sensitivity to insulin a ...
Gustation - West Virginia University
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G-Protein Coupled Receptor
G-Protein Coupled Receptor

... signals from receptors  target molecules  Protein kinase: enzyme that phosphorylates and activates proteins at next level  Phosphorylation cascade: enhance and amplify signal ...
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Learning at the Cellular Level
Learning at the Cellular Level

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... (anterogradly) to the axon terminal. Before being “ready for use”, they go through maturation processes which involve the cleavage of the precursor, resulting in multple neuropeptides. (The cleavage might even happen outside the cell, a bit later.) After exocytosis, they bind to the metabotropic rec ...
Diapositive 1
Diapositive 1

... neurotransmitter in the brain is converted into the major inhibitory neurotransmitter in the brain. -The synaptic actions of the amino acid neurotransmitters are terminated by selective uptake into the presynaptic terminals and glia via specific Na+ -dependent ...
Ch. 48-49 Nervous System 9e S13
Ch. 48-49 Nervous System 9e S13

... • Bind to receptors on neurons, muscle cells, or gland cells • Broken down by enzymes or taken back up into surrounding cells • Types of neurotransmitters: – Excitatory: speed up impulses by causing depolarization of postsynaptic membrane – Inhibitory: slow impulses by causing hyperpolarization of p ...
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... •Cell bodies – midbrain and brain stem raphe nuclei Ascending pathways - fore brain regions (hippocampus, striatum, amygdalae, hypothalamus and cerebral cortex) o5- HT has a modulatory role in aspects of behaviour including mood, emotion, sleep , wakefulness and regulation of circadian functions , ...
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... αlpha & βeta Receptors • α1 & β1 produce excitation when activated • α2 & β2 receptors cause inhibition of effector tissues • β3 found only on cells of brown adipose where activation causes thermogenesis (heat production) ...
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Study Guide

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Unit 2: Nervous System

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Chapter 6

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Chapter 4 lec 2

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ANP 214 REVIEW QUESTIONS 1

... 9. Close examination of an effector organ shows that it receives innervation by way of two neurons. The first is located in the spinal cord and synapses with a second in a chain ganglion. Chemical analysis indicates that the postsynaptic neuron releases acetylcholine and that the effector has many ...
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IV. Conduction Across Synapses

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Chemistry of Neurotransmitters

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Physiology2 - Sheet#8 - Dr.Loai Alzgoul - Done By: Mais

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Neurotransmitters
Neurotransmitters

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Neurotox I
Neurotox I

... being expressed as a variety of alterations in development. The effects of toxicant exposure will be markedly affected not only by dose/concentration, but also by timing. Insults by the same dose/concentration at different times during development may result in markedly different sequelae. Extrapola ...
Types of Receptors
Types of Receptors

... joints and visceral organs. • Touch and pressure employ 3 kinds of receptors • 1) Free nerve endings in between epithelial cells • 2) Meissner’s Corpuscles – most common in hairless portions of the skin. Most responsive to light touch. • 3) Pacinian’s Corpuscles – Found in the subcutaneous layers of ...
Limbic system
Limbic system

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Endocannabinoid system

The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as ""endocannabinoids"" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems.The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized form the endocannabinoid system.The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.
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