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A Lipid Gate for the Peripheral Control of Pain
A Lipid Gate for the Peripheral Control of Pain

... and Herkenham, 1999). Indeed, cellspecific deletion of CB1 in mouse nociceptive neurons impairs the antinociceptive effects of local or systemic (but not intrathecal) administration of cannabinoid agents (Agarwal et al., 2007). CB2 receptors, on the other hand, are primarily found in immune cells, s ...
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Neuroanatomy
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... neurotransmitter has been released, the next neuron will react differently. Since nerve cells are connected to the brain, muscles, glands, etc., the entire human body reacts different depending upon what type of neurotransmitter has been released. ...
Slide 1
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... neurotransmitter has been released, the next neuron will react differently. Since nerve cells are connected to the brain, muscles, glands, etc., the entire human body reacts different depending upon what type of neurotransmitter has been released. ...
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... and potassium amount inside and outside of neuron cell. 6. When a neuron at rest, what is the amount of sodium amount outside and inside the cell? 7. When a neuron at rest, what is the amount of K+ ions inside and outside the neuron cell? 8. Functions of sodium-potassium pumps during action potentia ...
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Endocannabinoid system

The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as ""endocannabinoids"" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems.The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized form the endocannabinoid system.The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.
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