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I want my money back!/recalls
I want my money back!/recalls

... recycled. Nobody can verify what happened when it went home with pt. must be destroyed. •inpatient hospital----drug is still packaged and not tampered with. destroy if opened. •manufacturer recall---when recommended by FDA •class I recall----can cause serious problems or death •class II recall-----t ...
Nutt - pharmacodynamics
Nutt - pharmacodynamics

... which allow the binding of neurotransmitters or hormones. These specialized binding pockets are called the pharmacophore and they convey the exquisite selectivity of receptors for substances such as neurotransmitters and drugs. The avidity (or stickiness) with which a neurotransmitter or drug binds ...
mechanisms for activation and inactivation of endorphins
mechanisms for activation and inactivation of endorphins

... The concept that the population of receptor sites for the enkephalins and endorphins is heterogeneous, is based on the following experimental approaches. When the peptides are assayed in two pharmacological and two binding models, the rank order of activity differs in the four systems. The antagonis ...
cardiovascular drugs - Melanie Costin, LVT
cardiovascular drugs - Melanie Costin, LVT

... heart, allowing the parasympathetic system to control the heart. Conduction of impulses and heart rate will slow down. • Also called Negative Inotropic drugs as the heart will contract with less force. • Will see a prolonged interval between P wave and QRS complex (slowed conduction through AV node) ...
CARDIOVASCULAR DRUGS
CARDIOVASCULAR DRUGS

... heart, allowing the parasympathetic system to control the heart. Conduction of impulses and heart rate will slow down. • Also called Negative Inotropic drugs as the heart will contract with less force. • Will see a prolonged interval between P wave and QRS complex (slowed conduction through AV node) ...
Drugs Hanson 15
Drugs Hanson 15

... - What are the possible side effects of the drug? - How should the drug be taken to minimize problems and maximize benefits? © LiquidLibrary ...
When or if to re-start ACEI, ARB, diuretics and other antihypertensive
When or if to re-start ACEI, ARB, diuretics and other antihypertensive

... 1. The original indication for the use of the drug should be reviewed. 2. If a specific contraindication to the use of an ARB/ACEI has been identified (e.g. severe bilateral renal artery stenosis), an alternative drug should be used. 3. For patients previously stabilized on drugs for the treatment o ...
8-Anti-mycobacterial drugs
8-Anti-mycobacterial drugs

... Clofazimine is a phenazine dye with Antimycobacterial and Antiinflammatory effect. Clofazimine is bactericidal against M. tuberculosis, is bacteriostatic against M. leprae, and is active against M. avium intracellulare. The drug enhances the phagocytic activity of Neutrophils and Macrophages, and re ...
item[`#file`]
item[`#file`]

... o Guilt – have you ever felt guilty about how much you drink? o Eyeopener – have you ever had a drink first thing in the morning for steady nerves/hangover? Alcoholism Treatment  Abstain – 1/3 abstain completely from drinking after treatment  Improvement – 1/3 improve to drinking less often after ...
1 (6 - Angelfire
1 (6 - Angelfire

... 51. Which one of the following descriptions of "Low risk Human papillomavirus (HPV)" is not correct? 1. HPV-6 is low-risk type HPV. 2. HPV-11 is low-risk type HPV. 3. Low risk HPVs are detected in Genital condylomas ...
ksir_ch05 - Homework Market
ksir_ch05 - Homework Market

... barrier (thus have an effect on the brain) If a drug passes the blood-brain barrier it will probably pass the placental barrier also Active transport systems may be needed to move chemicals in and out of the brain Trauma and infections can impair the blood-brain ...
SUSTAINED RELAEASE MULTIPARTICULATE DRUG DELIVERY
SUSTAINED RELAEASE MULTIPARTICULATE DRUG DELIVERY

... Ideally, a drug should arrive rapidly at the site of action in the optimum concentration, remain for the desired time, be excluded from other sites, and be rapidly removed when the goal is achieved. However, where highly water-soluble drugs are concerned, formulation into a dosage form is tricky and ...
Dr. Mary Teeling Dept. of Pharmacology & Therapeutics / Centre for
Dr. Mary Teeling Dept. of Pharmacology & Therapeutics / Centre for

... to the pharmacological action of the drug • Certain patient characteristics may predispose to ADRs • Prescribing information on each drug gives details of contraindications and special precautions for use • Pharmacogenomics may help to further elucidate susceptibility to ADRs in future ...
Lysergic Acid Diethylamide (LSD)
Lysergic Acid Diethylamide (LSD)

... that is so strong that a single flake can cause actions similar to mental illness. There are many factors involved in the effects hallucinogens will have. For example, the size of the dose, emotional state of mind of the user, and the surroundings all play a role in determining whether the user has ...
06. ANTHELMINTIC DRUGS 2006(nov 25).
06. ANTHELMINTIC DRUGS 2006(nov 25).

... less than 10% of orally administered drug is absorbed  Absorption increases with fatty meal.  Absorbed drug is 90 % protein bound  Converted to inactive metabolites .  Half- life of 2-6 hours  Excreted mostly in urine . ...
Pharmacologic Treatments - University of Kentucky | Medical Center
Pharmacologic Treatments - University of Kentucky | Medical Center

... • Restless legs – Dopamine agonists (e.g. Mirapex) ...
Fact Sheet - BioMolecular Products
Fact Sheet - BioMolecular Products

... Lym-X-Sorb™ (Lymphatic Xenobiotic AbSorbability), winner of the 2004 Eurand Award, is a unique drug delivery with controlled release. Lym-X-Sorb™ was developed as an analogue to the basic products of fat digestion by David W. Yesair, PhD., founder of BioMolecular Products, Inc. Dr. Yesair first desc ...
GLUTETHIMIDE
GLUTETHIMIDE

... *Several locating reagents can be used. Mercurous nitrate reagent is the most specific, and gives a dark grey response with a sensitivity of approximately 10 ng. However, the purple response produced by mercuric chloridediphenylcarbazone reagent, and the positive reaction to Dragendorff or .)acidifi ...
Effects of Three Reversal Agents on Detomidine- Induced
Effects of Three Reversal Agents on Detomidine- Induced

... Detomidinea gel is well absorbed and elicits many of the same cardiac and behavioral changes observed with the parental formulations. Antagonism of central nervous system and cardiovascular effects by ␣2 antagonists after parenteral administration of detomidine have been well characterized. The goal ...
Prescription Drug Abuse Glossary and Resource Guide
Prescription Drug Abuse Glossary and Resource Guide

... The mission of the Drug Enforcement Administration is to enforce the controlled substances laws and regulations of the United States and bring to the criminal and civil justice system of the United States, or any other competent jurisdiction, those organizations and principal members of organization ...
Prescription pattern in Nigeria
Prescription pattern in Nigeria

... Fawibe AE, Onyedum CC, Sogaolu OM, Ajayi AO, Fasae AJ. Drug prescription pattern for asthma among nigerian doctors in general practice: A crosssectional survey. Ann Thorac Med. 2012 Apr;7(2):78-83. WHO (2001) WHO Global strategy for the containment of antimicrobial resistance. Geneva: World Health O ...
III Clinical trials
III Clinical trials

Aspirin
Aspirin

... A substance that alter normal bodily function. Drugs are divided into two different groups: 1. Recreational Drugs (ex: alcohol) chemical substances that affect the central nervous system, such as opioids or hallucinogens. They may be used for perceived beneficial effects on perception, consciousness ...
Document
Document

... iii. The three processes of excretion in the kidney are: filtration, tubular secretion, and reabsorption. 1. Not all drugs are eliminated, so there is a reabsorption mechanism in the kidney. h. Try to understand that absorption and elimination of a compound are opposite. When we are talking about ab ...
Principles of Pharmacology
Principles of Pharmacology

... distribution and elimination. In Hardman JG, editors. The Goodman & Gilman’s the pharmacoligical basis of therapeutics. 9th edition. McGraw-Hill companies, Inc, 1996 : 328. 2. Holford NHG and Benet LZ. Pharmacokinetics & pharmacodynamics : rational dose selection & the time course of drug action. In ...
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Drug interaction



A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.
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