IOSR Journal of Dental and Medical Sciences (JDMS)
... 1. Articaine has a faster onset of action[3] 2. Articaine has a longer duration of action[3] 3. Articaine has a higher success rate[3, 9] 4. Articaine has a greater potency (1.5 times more potent)[3, 8, 9] 5. Systemic intoxication of Articaine is lower[4, 6] 6. Articaine is a very safe drug[4] The f ...
... 1. Articaine has a faster onset of action[3] 2. Articaine has a longer duration of action[3] 3. Articaine has a higher success rate[3, 9] 4. Articaine has a greater potency (1.5 times more potent)[3, 8, 9] 5. Systemic intoxication of Articaine is lower[4, 6] 6. Articaine is a very safe drug[4] The f ...
Phytosomes - Journal of Chemical and Pharmaceutical Research
... system. These are the cells, which are able to carry themselves from a hydrophilic to the lipid environment of the cell membrane, which ultimately reaches the blood. The hydrophilic plant constituents, which find their application in skin disorders, anti-ageing possess and different type of carcinom ...
... system. These are the cells, which are able to carry themselves from a hydrophilic to the lipid environment of the cell membrane, which ultimately reaches the blood. The hydrophilic plant constituents, which find their application in skin disorders, anti-ageing possess and different type of carcinom ...
Thorough QTc Studies: Patients at Heart...
... avoid biased results due to the autonomic variability in patients with advanced stage Parkinson’s disease. Time – matched QTc changes from baseline at separate data points of the study (ΔQTc values) are also presented. These are more detailed than the normalized areas under the QTc curve. Parallel-g ...
... avoid biased results due to the autonomic variability in patients with advanced stage Parkinson’s disease. Time – matched QTc changes from baseline at separate data points of the study (ΔQTc values) are also presented. These are more detailed than the normalized areas under the QTc curve. Parallel-g ...
A Review of Withdraw Strategies for Discontinuing Antiepileptic
... and effective use of these pain management therapies. Prescribers have turned to older non-‐opioid analgesic agents for treating pain including the application of agents not indicated for use in pain. Since ...
... and effective use of these pain management therapies. Prescribers have turned to older non-‐opioid analgesic agents for treating pain including the application of agents not indicated for use in pain. Since ...
Influence of weather conditions, drugs and
... The Kantonsspital St. Gallen is the main tertiary referral centre in eastern Switzerland. All consecutive patients admitted to the Department of Internal Medicine between January 2002 and July 2004 were retrospectively included in this study. Patients on dialysis and those with an estimated glomerul ...
... The Kantonsspital St. Gallen is the main tertiary referral centre in eastern Switzerland. All consecutive patients admitted to the Department of Internal Medicine between January 2002 and July 2004 were retrospectively included in this study. Patients on dialysis and those with an estimated glomerul ...
the laboratory`s role in opioid pain medication monitoring
... body temperature. Death can result from respiratory depression. Morphine can be administered orally or via s.c., i.m. or i.v. injections. The bioavailability of oral morphine is variable, reported between 15% and 65%, and that of injected morphine is approximately 95% of the dose administered. The h ...
... body temperature. Death can result from respiratory depression. Morphine can be administered orally or via s.c., i.m. or i.v. injections. The bioavailability of oral morphine is variable, reported between 15% and 65%, and that of injected morphine is approximately 95% of the dose administered. The h ...
Transdermal Fentanyl
... When titrating, the recommended upward dose titration interval should not be more frequent than every 72 hours. • Place patches on non‐irradiated, hairless skin. If needed, clip hair, don’t shave, as shaving can cause micro abrasions which may affect drug absorption. If site needs to be washed, d ...
... When titrating, the recommended upward dose titration interval should not be more frequent than every 72 hours. • Place patches on non‐irradiated, hairless skin. If needed, clip hair, don’t shave, as shaving can cause micro abrasions which may affect drug absorption. If site needs to be washed, d ...
The behavioral pharmacology of hallucinogens
... The observation of drug-elicited behaviors can be immensely helpful in the initial characterization of the pharmacological actions of new compounds in vivo. For instance, the Straub tail reaction in rodents (contraction of the sacrococcygeus muscle, resulting in erection of the tail) is readily obse ...
... The observation of drug-elicited behaviors can be immensely helpful in the initial characterization of the pharmacological actions of new compounds in vivo. For instance, the Straub tail reaction in rodents (contraction of the sacrococcygeus muscle, resulting in erection of the tail) is readily obse ...
OPIATE ANALGESICS AND ANTAGONISTS
... Spinal analgesia, respiratory depression , and decrease GIT motility . They are not true opioid receptors only some opioids react with them . ...
... Spinal analgesia, respiratory depression , and decrease GIT motility . They are not true opioid receptors only some opioids react with them . ...
IND, NDA, ANDA, CONCEPT OF PARA I TO IV,
... Third section : List of all formulations used in clinical trials and invivo bioavailability or pharmacokinetic studies together with each formulation used in studies. Fourth section : Analytical methods used to measure the levels of drug and major metabolite Fifth section : Dissolution data on each ...
... Third section : List of all formulations used in clinical trials and invivo bioavailability or pharmacokinetic studies together with each formulation used in studies. Fourth section : Analytical methods used to measure the levels of drug and major metabolite Fifth section : Dissolution data on each ...
LSD is a powerful hallucinogen. It has short and long term
... It’s possible to have a “bad trip” where the experience is negative and traumatic. There are things you can do if you or someone else has a bad trip. There are other issues with LSD as well. What’s LSD? LSD is a chemical that comes from a fungus. It’s a white powder, but often comes soaked up on bl ...
... It’s possible to have a “bad trip” where the experience is negative and traumatic. There are things you can do if you or someone else has a bad trip. There are other issues with LSD as well. What’s LSD? LSD is a chemical that comes from a fungus. It’s a white powder, but often comes soaked up on bl ...
DESIGN AND CHARACTERIZATION OF MODIFIED RELEASE ISONIAZID AND SALBUTAMOL
... required, so cost effective, core is visible, so coreless tablets can be easily detected, reduction in coating forms a thinner tablet and thus freedom from capping of top coating. The present invention also teaches the use of dual retard technique to effectively control the release rate of modified ...
... required, so cost effective, core is visible, so coreless tablets can be easily detected, reduction in coating forms a thinner tablet and thus freedom from capping of top coating. The present invention also teaches the use of dual retard technique to effectively control the release rate of modified ...
Warfarin-herb interactions: a review and study based on assessment
... safe. A major safety concern is the potential interactions of alternative medicinal products with prescription medications like anticoagulants. Herbs that may augment or inhibit the effects of anti-coagulant or antiplatelet therapy are of particular interest because this therapy is so widespread. Th ...
... safe. A major safety concern is the potential interactions of alternative medicinal products with prescription medications like anticoagulants. Herbs that may augment or inhibit the effects of anti-coagulant or antiplatelet therapy are of particular interest because this therapy is so widespread. Th ...
NEW SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS DETERMINATION OF AMLODIPINE BESYLATE AND ATORVASTATIN CALCIUM IN TABLET DOSAGE FORMS
... on measurement of absorptivity at 238.8 nm (as an iso‐absorptive point) and 246 nm. AMD and ATR at their respective maximum wavelength 361 nm and 246 nm and at isoabsorptive point 238.8 nm shows linearity in a concentration range of 0.5‐30 µg/mL. Recovery studies range from > ...
... on measurement of absorptivity at 238.8 nm (as an iso‐absorptive point) and 246 nm. AMD and ATR at their respective maximum wavelength 361 nm and 246 nm and at isoabsorptive point 238.8 nm shows linearity in a concentration range of 0.5‐30 µg/mL. Recovery studies range from > ...
Opioid Pharmacology
... Binding Affinity is measured by the equilibrium inhibition constant (Ki) for [H*] sufentanil (nM). The lower the value of (Ki), the Higher the binding affinity for the µ-receptor. ...
... Binding Affinity is measured by the equilibrium inhibition constant (Ki) for [H*] sufentanil (nM). The lower the value of (Ki), the Higher the binding affinity for the µ-receptor. ...
the effects of zolmitriptan on nasal mucociliary clearance (nmcc)
... Measuring the speed at which particles are moved by cilia gives us objective information about one of the most important physiological actions of the respiratory tract .Because many drugs enhance but other reduce the mucociliary clearance so we can evaluate various drugs as to this action2.The sacch ...
... Measuring the speed at which particles are moved by cilia gives us objective information about one of the most important physiological actions of the respiratory tract .Because many drugs enhance but other reduce the mucociliary clearance so we can evaluate various drugs as to this action2.The sacch ...
Pleasure into pain: The consequences of long
... studies have shown that despite the aim of methadone maintaining a constant effect throughout the day, there is significant fluctuation in a range of responses from trough to peak. These include physiological responses (e.g., respiration rate, pupil size) and subjective changes (e.g., withdrawal sym ...
... studies have shown that despite the aim of methadone maintaining a constant effect throughout the day, there is significant fluctuation in a range of responses from trough to peak. These include physiological responses (e.g., respiration rate, pupil size) and subjective changes (e.g., withdrawal sym ...
induction of etorphine immobilization in blue Accelerated
... 2000). The latter study concluded that no clear dose/response relationship between HA dose and quality of block existed. While the exact reason for the difference is unknown, the space within the drug is administered is probably directly related to the effect achieved. For the orbit, where the space ...
... 2000). The latter study concluded that no clear dose/response relationship between HA dose and quality of block existed. While the exact reason for the difference is unknown, the space within the drug is administered is probably directly related to the effect achieved. For the orbit, where the space ...
HIV treatment
... • Chain Termination (No 3’ Hydroxyl group: no phosphodiester linkage with incoming dNTP alpha-phosphate) •Pros of NRTIs: effective treatment method when used in combination with other HIV treatments in HAART to decrease resistance mutations •Cons of NRTIs: 1. Limitations in treatment safety – NRTIs ...
... • Chain Termination (No 3’ Hydroxyl group: no phosphodiester linkage with incoming dNTP alpha-phosphate) •Pros of NRTIs: effective treatment method when used in combination with other HIV treatments in HAART to decrease resistance mutations •Cons of NRTIs: 1. Limitations in treatment safety – NRTIs ...
Maryland Opioid Overdose Prevention Plan January 2013
... both recipients and providers that could contribute to the misuse of pharmaceutical opioids. Although these programs have been developed primarily for the purpose of quality assurance, cost containment and fraud detection, they will be utilized as a component of strategies to reduce opioid overdose. ...
... both recipients and providers that could contribute to the misuse of pharmaceutical opioids. Although these programs have been developed primarily for the purpose of quality assurance, cost containment and fraud detection, they will be utilized as a component of strategies to reduce opioid overdose. ...
Guideline on clinical investigation of medicinal products in the
... DBP should be recorded. The disappearance of sound (Korotkov phase V) should be used for the diastolic reading. Two or more readings separated by 2 minutes should be averaged. If the first two readings of SBP differ by more than 5 mmHg, additional readings should be obtained. Blood pressure should b ...
... DBP should be recorded. The disappearance of sound (Korotkov phase V) should be used for the diastolic reading. Two or more readings separated by 2 minutes should be averaged. If the first two readings of SBP differ by more than 5 mmHg, additional readings should be obtained. Blood pressure should b ...
4 2. LITERATURE REVIEW: Ariyana, et al (2014), developed
... Fouad H, et al (2013), performed a study to develop a biodegradable periodontal chip containing thymoquinone and chitosan and to evaluate its effectiveness for managing chronic periodontitis. Overall, 180 periodontal pockets were evaluated. It was concluded that periodontal chips containing thymoqu ...
... Fouad H, et al (2013), performed a study to develop a biodegradable periodontal chip containing thymoquinone and chitosan and to evaluate its effectiveness for managing chronic periodontitis. Overall, 180 periodontal pockets were evaluated. It was concluded that periodontal chips containing thymoqu ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.