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Dna rEPLICATION - Manning`s Science
Dna rEPLICATION - Manning`s Science

... The other daughter strand that cannot grow towards the replication fork, therefore it grows in the opposite direction  It is built in short segments (in the 5’  3’ direction) away from the replication fork.  This is much slower than the leading strand! ...
Chap 3 Recombinant DNA Technology
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... Multiple cloning sites: allow the choice of different restriction enzyme (containing many restriction recognition sites) ...
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DNA: Contamination Control - Sacramento County District Attorney
DNA: Contamination Control - Sacramento County District Attorney

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... In an electrophoretic gel across which is applied a powerful electrical alternating pulsed field, the DNA of the haploid fungus Neurospora crassa (n = 7) moves slowly but eventually forms seven bands, which represent DNA fractions that are of different sizes and hence have moved at different speeds. ...
DNA Replication, RNA Molecules and Transcription
DNA Replication, RNA Molecules and Transcription

... A transcription reaction requires a DNA molecule to serve as template for transcription with a promoter (and, in vivo, transcription factors) to indicate where to begin transcribing and which strand to transcribe. Transcription reactions also require an RNA polymerase that recognizes the promoter on ...
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... Encephalitozoon cuniculi genome sequencing methods Genomic libraries. Two libraries were constructed: (1) a 2.3x104 clone library in the plasmid vector BAM3 (Dr. Roland Heilig, unpubl. construction derived from pBluescript II KS + , Stratagene) harboring total genome DNA which was restricted randoml ...
Cells, Chromosomes, Genes
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... The National Academy of Sciences first recommended the use of the Ceiling Principle back in the late 1980s. The idea was to provide the most conservative estimate of probability but in the mid 1990 it fell out of favor Advances in DNA fingerprinting • In the eighties the number of VNTRs used was sma ...
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Molecular cloning



Molecular cloning is a set of experimental methods in molecular biology that are used to assemble recombinant DNA molecules and to direct their replication within host organisms. The use of the word cloning refers to the fact that the method involves the replication of one molecule to produce a population of cells with identical DNA molecules. Molecular cloning generally uses DNA sequences from two different organisms: the species that is the source of the DNA to be cloned, and the species that will serve as the living host for replication of the recombinant DNA. Molecular cloning methods are central to many contemporary areas of modern biology and medicine.In a conventional molecular cloning experiment, the DNA to be cloned is obtained from an organism of interest, then treated with enzymes in the test tube to generate smaller DNA fragments. Subsequently, these fragments are then combined with vector DNA to generate recombinant DNA molecules. The recombinant DNA is then introduced into a host organism (typically an easy-to-grow, benign, laboratory strain of E. coli bacteria). This will generate a population of organisms in which recombinant DNA molecules are replicated along with the host DNA. Because they contain foreign DNA fragments, these are transgenic or genetically modified microorganisms (GMO). This process takes advantage of the fact that a single bacterial cell can be induced to take up and replicate a single recombinant DNA molecule. This single cell can then be expanded exponentially to generate a large amount of bacteria, each of which contain copies of the original recombinant molecule. Thus, both the resulting bacterial population, and the recombinant DNA molecule, are commonly referred to as ""clones"". Strictly speaking, recombinant DNA refers to DNA molecules, while molecular cloning refers to the experimental methods used to assemble them.
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