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How Neurons and Synapses Work
How Neurons and Synapses Work

Brain Muscle Interface
Brain Muscle Interface

... brain is compromised and within minutes, brain cells begin to die. There are two kinds of stroke. The more common kind, called ischemic stroke, is caused by a blood clot that blocks or plugs a blood vessel in the brain. The other kind, called hemorrhagic stroke, is caused by a blood vessel that brea ...
PCL - mmc7
PCL - mmc7

... Lower motor neurons: these carry nerve impulses from the spinal cord (or brainstem for cranial nerves) to the muscle Decussation: the crossing over of upper motor neurons Suppose that left-sided facial weakness arises. Where could this pathology be? 1. Left side lower-motor neuron 2. Right side uppe ...
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15-1 Section Summary
15-1 Section Summary

... called neurons, or nerve cells. The message that a neuron carries is called a nerve impulse. A neuron has a large cell body that contains the nucleus. The cell body has threadlike extensions. One kind of extension, a dendrite, carries impulses toward the cell body of the neuron. An axon carries impu ...
ANSWERS TO CHAPTER 8
ANSWERS TO CHAPTER 8

... and one axon. Bipolar neurons have one dendrite and one axon, and unipolar neurons have a single process that functions as both an axon and a dendrite. ...
Control of Movement
Control of Movement

...  Simple – 2 neuronal system of sea angel  Complex – mammals (some species can walk right after birth)  Humans – 1 year for walking (Toddlers can’t walk, because there isn’t a strong enough skeleton-muscular and neuronal system.) ...
are you ready - Plain Local Schools
are you ready - Plain Local Schools

Nervous System - Academic Computer Center
Nervous System - Academic Computer Center

... Presynaptic inhibition results when another neuron inhibits the release of excitatory neurotransmitter from a presynaptic cell. ...
Pull out the stops for plasticity
Pull out the stops for plasticity

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electrochemical impulse
electrochemical impulse

... generated by the movement of ions through the membrane. • When the nerve is excited, the potential charge difference across the membrane changes to +40 mV. This is called the action potential. • When excitation of the nerve occurs, the membrane becomes more permeable to sodium ions. It is believed t ...
11: Fundamentals of the Nervous System and Nervous Tissue
11: Fundamentals of the Nervous System and Nervous Tissue

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Slide 1
Slide 1

... • A neuron has a pre-set level of stimulation that needs to be met or exceeded in order for it to pass the received impulses on to the next neuron. This is called a neuron’s threshold. ...
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Worksheet for Nervous Systems

... 29. Define each type of “graded potential”. Tell which ion channel is involved in each type of “graded potential”. ...
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MOTOR SYSTEM – Muscle, LMC, Spinal cord mechanisms of control

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Cellular Mechanisms of Learning and Memory

... PKA recruits the mitogen-activated kinase (MAPK) and together they translocate to the nucleus (long-term pathway), where PKA phosphorylates the cAMP-response element binding (CREB) protein. One gene activated by CREB encodes a ubiquitin hydrolase, which in turn cause persistent activity of PKA. The ...
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Neuron PowerPoint

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Nervous System I
Nervous System I

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Unit 2-Week 1 Notes Sheets

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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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