Chronic Renal Failure in Children
... • Adults and children with CRF maintain nutrition status when given very low protein diet supplemented with ketoacids • In adults, the MDRD study was unable to demonstrate that either low protein diets or very low protein diets supplemented with ketoacids were effective at slowing the rate of progre ...
... • Adults and children with CRF maintain nutrition status when given very low protein diet supplemented with ketoacids • In adults, the MDRD study was unable to demonstrate that either low protein diets or very low protein diets supplemented with ketoacids were effective at slowing the rate of progre ...
A theory of drug tolerance and dependence II: the
... model demonstrate the model’s behaviour to be consistent with important characteristics of the development of tolerance to repeatedly administered drugs: the gradual decrease in drug effect when tolerance develops, the high sensitivity to small changes in drug dose, the rebound phenomenon and the la ...
... model demonstrate the model’s behaviour to be consistent with important characteristics of the development of tolerance to repeatedly administered drugs: the gradual decrease in drug effect when tolerance develops, the high sensitivity to small changes in drug dose, the rebound phenomenon and the la ...
Fitting Compartmental Models to Multiple Dose Pharmacokinetic Data using SAS® PROC NLMIXED
... construct mean functions for fitting data from multiple dose studies. One-compartment models for oral dose administration are considered to illustrate the methodology and challenges for fitting multiple dose data using PROC NLMIXED. The template program contains SAS sample codes for fitting two type ...
... construct mean functions for fitting data from multiple dose studies. One-compartment models for oral dose administration are considered to illustrate the methodology and challenges for fitting multiple dose data using PROC NLMIXED. The template program contains SAS sample codes for fitting two type ...
PDF - International Journal of Drug Development and Research
... ©2013 IJDDR Development and Optimization of Gastroretentive drug delivery system for Oseltamivir Yong Tze Teen1, Adinarayana Gorajana1*, P. S. Rajinikanth1, Sreenivas Patro Sisinthy2, ...
... ©2013 IJDDR Development and Optimization of Gastroretentive drug delivery system for Oseltamivir Yong Tze Teen1, Adinarayana Gorajana1*, P. S. Rajinikanth1, Sreenivas Patro Sisinthy2, ...
SPECTROPHOTOMETRIC DETERMINATION OF PIZOTIFEN MALEATE IN BULK DRUG AND TABLETS
... precision and accuracy of the methods have been evaluated. Conclusion: The methods were successfully applied to the assay of PZT in tablets preparations and the results were statistically compared with those of the reference method by applying Student’s t-test and F-test. No interference was observe ...
... precision and accuracy of the methods have been evaluated. Conclusion: The methods were successfully applied to the assay of PZT in tablets preparations and the results were statistically compared with those of the reference method by applying Student’s t-test and F-test. No interference was observe ...
Blue with White Corner
... techniques to measure concentration of drug in plasma. • Noninvasive method therefore better subject compliance. • Convenience of collecting urine samples in comparison to drawing of blood periodically. • If any case the urine drug concentration is low, assaying of larger sample volume is relatively ...
... techniques to measure concentration of drug in plasma. • Noninvasive method therefore better subject compliance. • Convenience of collecting urine samples in comparison to drawing of blood periodically. • If any case the urine drug concentration is low, assaying of larger sample volume is relatively ...
The Impact of Hepatic Uptake on the Pharmacokinetics of Organic
... Vss. This methodology significantly improved the prediction of metabolic in vivo clearance compared with standard hepatocyte scaling approaches that do not take into account hepatic uptake. Predictions of Vss from the media loss assay also correlate with the measured values from plasma PK analysis. ...
... Vss. This methodology significantly improved the prediction of metabolic in vivo clearance compared with standard hepatocyte scaling approaches that do not take into account hepatic uptake. Predictions of Vss from the media loss assay also correlate with the measured values from plasma PK analysis. ...
On the origin of the WD1145 disk and pollution
... passes through a disk for timescale tdisk For the population: • The mean rates are drawn from a distribution where log(dM/dt)in has a mean µ and deviation σ • The distribution of tsink is that of the unbiased sample ...
... passes through a disk for timescale tdisk For the population: • The mean rates are drawn from a distribution where log(dM/dt)in has a mean µ and deviation σ • The distribution of tsink is that of the unbiased sample ...
Nota Técnica
... determination (R2) were calculated and those with a value higher than 0.99 were considered linear. For those, steady-state diffusion flux (Js) was determined from the linear slope of the cumulative amount of EGCG versus time curve. The lag time (TL) represented the time required to achieve the stead ...
... determination (R2) were calculated and those with a value higher than 0.99 were considered linear. For those, steady-state diffusion flux (Js) was determined from the linear slope of the cumulative amount of EGCG versus time curve. The lag time (TL) represented the time required to achieve the stead ...
EVALUATION OF PRELIMINARY PHYTOCHEMICAL PROPERTIES AND HYPOGLYCEMIC CLEOME GYNANDRA Research Article
... Plants have been used as source of drugs for the treatment of diabetes mellitus in developing countries where the cost of conventional medicines represents a burden to the population. Many species have been reported to present antidiabetic activity [8].Working on the same line, we have undertaken a ...
... Plants have been used as source of drugs for the treatment of diabetes mellitus in developing countries where the cost of conventional medicines represents a burden to the population. Many species have been reported to present antidiabetic activity [8].Working on the same line, we have undertaken a ...
Simulation of Dynamic Electrochemical Processes
... The equations for these means of mass transport are available, but are quite complicated and so in the first instance, migration ( the movement of a charged species because of a potential field), is experimentally removed through the addition of excess electrolyte and convection is removed by not st ...
... The equations for these means of mass transport are available, but are quite complicated and so in the first instance, migration ( the movement of a charged species because of a potential field), is experimentally removed through the addition of excess electrolyte and convection is removed by not st ...
EFFECTS OF MUCOADHESIVE POLYMERS COMBINATION ON THE PROPERTIES OF LISINPRIL
... required detaching the tablet. The bioadhesive property of the prepared tablets of the formulations (F1, F2, and F3) with combined polymers, HPMC K100M and Chitosan showed the bioadhesive strengths of 2.64, 3.12, and 3.43 N respectively. The formulations (F4, F5, and F6) with HPMC K100M and CMC show ...
... required detaching the tablet. The bioadhesive property of the prepared tablets of the formulations (F1, F2, and F3) with combined polymers, HPMC K100M and Chitosan showed the bioadhesive strengths of 2.64, 3.12, and 3.43 N respectively. The formulations (F4, F5, and F6) with HPMC K100M and CMC show ...
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... This dosage regimen is very close to that found in part which is based on the drug - specific dosage regimen found in the USP/DI, however, the dose of Captopril for Milli based on normal adult dose and weight as given by Clark's Rule is not so successful. It gives a dose that is nearly 20 times the ...
... This dosage regimen is very close to that found in part which is based on the drug - specific dosage regimen found in the USP/DI, however, the dose of Captopril for Milli based on normal adult dose and weight as given by Clark's Rule is not so successful. It gives a dose that is nearly 20 times the ...
ADSORPTION AT INTERFACES
... and acids are amphiphiles that change from being predominantly hydrophilic to lipophilic as the number of C-atoms in the alkyl chain is increased. It is the amphiphilic nature of SAA's that causes them to be adsorbed at interfaces (either liquid/gas or liquid/liquid). Consider a fatty acid molecule ...
... and acids are amphiphiles that change from being predominantly hydrophilic to lipophilic as the number of C-atoms in the alkyl chain is increased. It is the amphiphilic nature of SAA's that causes them to be adsorbed at interfaces (either liquid/gas or liquid/liquid). Consider a fatty acid molecule ...