• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
File
File

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF TELMISARTAN AND INDAPAMIDE IN CAPSULE DOSAGE FORM
SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF TELMISARTAN AND INDAPAMIDE IN CAPSULE DOSAGE FORM

... sodium ions across renal tubular epithelium [6]. It also acts as a carbonic anhydrase inhibitor. Indapamide reaches maximum plasma concentration within 2-2.5 hours and half life is about 14-18 hours. ...
DOC - Primary Resources
DOC - Primary Resources

... ...
Myostatin Inhibition: A New Treatment for Androgen Deprivation
Myostatin Inhibition: A New Treatment for Androgen Deprivation

... peptibody-associated fatigue, if confirmed in larger studies, may reduce engagement in regular physical exercise. The observed improvements in body composition after only 4 weeks of AMG 745 treatment are intriguing, although the between-group differences may have been amplified by greater than expec ...
Ian Martin Slides PDF
Ian Martin Slides PDF

FABRICATION AND EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF TRAMADOL HYDROCHLORIDE
FABRICATION AND EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF TRAMADOL HYDROCHLORIDE

... suffer from osteoarthritis [1]. It is an opiod analgesic used to treat moderate to moderately severe pains. It is a centrally acting drug which acts by blocking the transmission of pain signals sent by the nerves to the brain [2]. Tramadol Hydrochloride is a very weak opioid receptor agonist which i ...
digibind - GSK Australia
digibind - GSK Australia

... TESTS). After treatment with Digibind, the serum potassium concentration may drop rapidly and must be monitored frequently, especially over the first several hours after Digibind is given (see LABORATORY TESTS). The elimination half-life in the setting of renal failure has not been clearly defined. ...
2014 EASO Position Statement on the Use of Anti
2014 EASO Position Statement on the Use of Anti

... considerably, at least in patients who are ‘manageable’. This improvement is due to the development of transdisciplinary approaches, including dietary, exercise and behavior modifications, while also considering psychosocial characteristics of patients. Pharmacological treatment should only be consi ...
DEVELOPMENT AND VALIDATION OF NEWER ANALYTICAL METHODS FOR THE ESTIMATION
DEVELOPMENT AND VALIDATION OF NEWER ANALYTICAL METHODS FOR THE ESTIMATION

... All the chemicals and reagents used were of analytical grade and procured from Qualigens India Ltd., Loba Chemicals Ltd. Preparation of Gibb`s reagents 0.1% Gibb`s reagent was prepared by weighing 100 mg of Gibb`s reagent into 100 ml volumetric flask and added minimum quantity of methanol to dissolv ...
Drugs Combinations in the Treatment of Obesity
Drugs Combinations in the Treatment of Obesity

How Drugs are Handled in the Body PDF
How Drugs are Handled in the Body PDF

MTH Week 8 Checkpoint Assignment -- Due Day 3
MTH Week 8 Checkpoint Assignment -- Due Day 3

... 28. The equation y = 12x + 5 shows the total cost for ordering tickets on the phone for a certain outdoor concert. Tickets are $12 each, and there is a one-time service fee of $5. Can the slope of this line be thought of as a rate? Explain. Answer: Yes,slope of the line is 12 and is the cost per tic ...
Slides  - University of Alberta
Slides - University of Alberta

Phases of Drug Metabolism - Thomas Jefferson University
Phases of Drug Metabolism - Thomas Jefferson University

... Milrinone ...
Strengths and Limitations of In Vitro Xenobiotic Metabolism Assays
Strengths and Limitations of In Vitro Xenobiotic Metabolism Assays

... employ in vivo-like levels of xenobiotic metabolism competence • The rapid loss of metabolic competence with suspension primary hepatocytes or subcellular fractions limits our ability to assess lower turnover compounds • Traditional in vitro assays for metabolic clearance with suspensions of primary ...
EVALUATION OF PHYSICAL PROPERTIES OF JIT-TRA-ROM FAST DISINTEGRATING TABLETS
EVALUATION OF PHYSICAL PROPERTIES OF JIT-TRA-ROM FAST DISINTEGRATING TABLETS

... from a sleeping disorder. Insomnia is the most common sleeping disorder, and it has been a major public health problem, affecting up to 48% of adults [1]. This problem has many consequences that may impact on health and quality of life, including development of depression, high costs of treatment an ...
Unit 5: Rotational Motion
Unit 5: Rotational Motion

Fibroblast Activation Protein (FAP) as a Novel
Fibroblast Activation Protein (FAP) as a Novel

... observed in DIO mice that TB robustly lowers body weight, blood glucose, plasma insulin and total cholesterol while improving glucose tolerance and insulin sensitivity. In contrast, these effects are much diminished in lean mice. We also found that TB elevates FGF21 levels in plasma of DIO but not i ...
Lecture Notes
Lecture Notes

Project Presentations - 2
Project Presentations - 2

... Not all tweets have hashtags Twitter is easy to spam/make bots ...
2003 Colloquium Poster
2003 Colloquium Poster

... Not extensively metabolized - produces only one non-reactive carboxylic metabolite. Figure 2: Comparison plots for Gabapentin and Levetiracetam in patient samples. All results are in g/mL. ...
About OMICS Group - 9 th Annual European Pharma Congress
About OMICS Group - 9 th Annual European Pharma Congress

...  Fraction of the dose of a drug contained in any dosage form that reaches the systemic circulation in unchanged or active form administered through any route is known as bioavailability.  Drugs injected using intravenous route of administration have 100% bioavailability, while others have much les ...
J.Grevel 25.05.07
J.Grevel 25.05.07

Drug-Induced Weight Gain: A Review for Pharmacy
Drug-Induced Weight Gain: A Review for Pharmacy

... Obesity and being overweight may decrease well-being, but also may increase morbidity and mortality.1 Weight gain results from an imbalance between energy intake and total energy expenditure. Numerous medications can, through different mechanisms, contribute to weight gain. However, the magnitude an ...
THE ESSENTIALS OF CHRONOPHARMACOTHERAPEUTICS  Review Article VIKRAM S. CHHABRA
THE ESSENTIALS OF CHRONOPHARMACOTHERAPEUTICS Review Article VIKRAM S. CHHABRA

... network composed of the paired suprachiasmatic nuclei (SCN) that are situated in the hypothalamus and the pineal gland.3 The rhythmic activities of specific, socalled, clock genes, like per1, per2, per3, bmal, clock, and CRY, among others, and their gene products, plus the cyclic (nocturnal) secreti ...
< 1 ... 55 56 57 58 59 60 61 62 63 ... 157 >

Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report