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Renal Dose Adjustment per Pharmacy
Renal Dose Adjustment per Pharmacy

... Renal Dose Adjustment per Pharmacy references. The new order will be signed in the electronic health record (EHR) using the order mode “Per Protocol: No Co-Sign” 1. The pharmacist will then write a note in the progress section of the EHR so that the medical staff will be informed of the adjustment. ...
High performance liquid chromatography, TLC
High performance liquid chromatography, TLC

IN VIVO COMPARATIVE BIOAVAILABILITY STUDY OF TWO VALPROIC ACID SYRUP
IN VIVO COMPARATIVE BIOAVAILABILITY STUDY OF TWO VALPROIC ACID SYRUP

... Methods: A randomized, two crossover design study was conducted on six healthy male rabbits. Rabbits received a single oral dose (25 mg/kg) of valproic acid formulations with a washout period of one week. Serial blood samples were collected over a period of 48 hours. Chemiluminescent enzyme immunoas ...
mind altering… synthetic (designer) and naturally occuring
mind altering… synthetic (designer) and naturally occuring

... an antiemetic and as an adjunct analgesic for neuropathic pain. It is a synthetic cannabinoid, which mimics the main ingredient of cannabis (THC). Chemically, nabilone is similar to the active ingredient found in naturally occurring Cannabis ...


... concentration, with B peak of about 7000 Itmom (normal range 50 to 100 wol/L). Ornithine concentrations also increased markedly but lagged behind the increase in arginine; plasma concentrations of other amino acids did not change significantly. Ammonia and urea concentrationa and acid-baee balance ( ...
pH TRIGGERED DRUG DELIVERY OF ORNIDAZOLE FROM EUDRAGIT COATED CHITOSAN MICROSPHERE:
pH TRIGGERED DRUG DELIVERY OF ORNIDAZOLE FROM EUDRAGIT COATED CHITOSAN MICROSPHERE:

... was maintained at 37±0.50C. After a time interval of 1 hr. sample were withdrawn and replaced with fresh media immediately after sampling. The samples withdrawn were analyzed for the drug content by scanning the sample at 262 nm using UV spectrophotometer (Shimadzu UV1800)  Kinetics and Mechanism o ...
presentation
presentation

...  ‫ן‬  ‫ן‬ ...
No Slide Title
No Slide Title

... The vapor pressure gives an indication of the ease with which a volatile anesthetic evaporates. The higher the vapor pressure, the more volatile the anesthetic. The saturated vapor pressure also dictates the maximum concentration of vapor that can exist at a given temperature. The higher the saturat ...


... chemical reaction has taken place amongst any of the constituents in the oro dispersive tablet formulation and thus it can be used for its desired purpose. Evaluation of Powder Blend The bulk density was found to be in the range of 0.44 – 0.59 g/cm3 and tapped density between 0.56 – 0.68 g/cm3 as me ...
Syllabus of B. Pharma
Syllabus of B. Pharma

... Sources of impurities in pharmaceutical substances and their control The following topics will be treated covering an outline of methods of preparation, tests for identity, assay procedure and pharmaceutical uses of compounds covered under following headings: Pharmaceutical aids and necessities: Aci ...
procainamide hcl
procainamide hcl

... The therapeutic plasma concentration: NAPA’s activity is similar to that of procainamide when equal plasma concentration are compared , however , other have found that approximately 10 to 20 mg/L are required for partial suppression of ventricular concentration . Plasma concentration of NAPA of appr ...
Sustained release drug delivery system
Sustained release drug delivery system

... drug at the site of action for a precise time period is usually approximated by most systems. This approximation is achieved bycreating a constant concentration in the body or an organ over an extended time; in other words, the amount of drug entering the system is equivalent to the amount of drug r ...
Mean conservation for density estimation via
Mean conservation for density estimation via



... that concentration of ALT and AST enzymes in all three experimental groups increased and in experimental group 3, concentration of ALK enzyme increased. Many studies on the adverse effects of fluoxetine on the liver have been done and high levels of aminotransferases [6-11] and acute hepatitis have ...
View Full Text-PDF
View Full Text-PDF

Temperature and pH Responsive Microfibers for Controllable and
Temperature and pH Responsive Microfibers for Controllable and

... in medical and pharmaceutical sciences.[1, 2] Controlled drug delivery systems have been successfully applied to cancer treatments and tissue engineering with a better improved efficacy.[3-5] However, there are still two major challenges to overcome 1) reducing initial burst effects and 2) realizing ...
pps - Chair of Computational Biology
pps - Chair of Computational Biology

Using a Tritiated Compound to Elucidate Its Preclinical Metabolic
Using a Tritiated Compound to Elucidate Its Preclinical Metabolic

... organic phase 3H levels may be ascribed to highly polar metabolites, HTO, or both. For total radioactivity PK analyses, 3H exchange causes similar data interpretation complexities as a result of tritium’s threecomponent exponential function biological half-life, ranging from 10 to 300 days in humans ...
As we know, there are two main areas of pharmacology, they are
As we know, there are two main areas of pharmacology, they are

... A man with angina has not understood instruction on the use of glyceryl trinitrate tablets. He swallows them instead of putting them under his tongue. There is no therapeutic benefit. You may ask swallowing glyceryl trinitrate tablets and putting them under his tongue, what is the distinction betwe ...
Use of Ergogenic Aids by Athletes
Use of Ergogenic Aids by Athletes

... and not get suspended for drug use. The second question was whether they would take the same substance if it would enhance their ability to win every competition for the next 5 years but then result in death. Remarkably, 98% responded “yes” to the first question, and more than 50% responded “yes” to ...
PHL 424 2nd S
PHL 424 2nd S

... is reabsorbed from the intestine (enterohepatic circulation) and contributes to maintenance of serum levels  Doxycycline, in contrast to other tetracyclines, is eliminated by nonrenal mechanisms (excreted in feces), does not accumulate significantly in renal failure, and requires no dosage adjustme ...
Chronic Renal Failure in Children
Chronic Renal Failure in Children

... • Adults and children with CRF maintain nutrition status when given very low protein diet supplemented with ketoacids • In adults, the MDRD study was unable to demonstrate that either low protein diets or very low protein diets supplemented with ketoacids were effective at slowing the rate of progre ...
Back to Basics: A Simple Guide to Calculations for
Back to Basics: A Simple Guide to Calculations for

... Program Overview: Brushing up on the basics of math is something that is essential for every pharmacy technician. Pharmaceutical calculations are a part of everyday life in the pharmacy practice, and your duty as a technician. These calculations are not too difficult, but require swift work, and acc ...
A Simple Guide to Calculations for Pharmacy Technicians
A Simple Guide to Calculations for Pharmacy Technicians

SIMULTANEOUS DETERMINATION AND VALIDATION OF AMOLODIPINE AND METAPROLOL
SIMULTANEOUS DETERMINATION AND VALIDATION OF AMOLODIPINE AND METAPROLOL

... centrifuge tube and centrifuged for 4000 rpm for 20 mins. The supernatant liquid is taken and diluted with diluents, to obtain approximately final concentration of 10 µg/ml and 100 µg/ml. This sample is analyzed in triplicate. The accuracy and concentration is determined using regression equation. ...
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Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
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