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Predicting Drug Metabolism - Cambridge Repository
Predicting Drug Metabolism - Cambridge Repository

Fluoxetine effect on gestation and fetal development
Fluoxetine effect on gestation and fetal development



... This study showed that FP concentrations in central lung tissue were about three to four times higher than in peripheral lung tissue, which in turn exceeded those found in serum by 100 times. No relevant information can be drawn from serum levels of inhaled steroids about the concentrations in the t ...
DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQUATION METHOD FOR
DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQUATION METHOD FOR

... Amount added (μg/ml) 80% (9μg/ml) 100% (10μg/ml) 120% (11μg/ml) 80%(9μg/ml) 100%(10μg/ml) 120%(11μg/ml) ...
O A
O A

... It is to be noted that antihyperglycemic and antinociceptive activities of the extract were measured in two separate groups of animals. This is standard procedure as reported in the scientific literature, for the two procedures for measurement of the two activities are different. Complications could ...
MS DOC
MS DOC

a high performance liquid chromatographic assay of rifampin in
a high performance liquid chromatographic assay of rifampin in

... transcription (Ref). Most strains of Mycobacterium tuberculosis are inhibited in vitro by rifampin concentrations of 0.5 μg/ml (Ref). Rifampin is quickly absorbed from the gastrointestinal tract with peak serum concentrations of 6-8 μg/ml occurring 1.5-2.0 hours after administration. It is 75% bound ...
formulation and evaluation of floating microspheres of diclofenac
formulation and evaluation of floating microspheres of diclofenac

Enhanced dissolution and oral bioavailability of coenzyme Q10 in
Enhanced dissolution and oral bioavailability of coenzyme Q10 in

... Purpose: The solubility of coenzyme Q10 (CoQ10) in water is extremely low, resulting in a low oral bioavailability. In this study, we attempted to improve the low dissolution and bioavailability of CoQ10, by means of the complexation with natural α-, β- and γ-cyclodextrins (CyDs) and 2-hydroxypropyl ...
ABSTRACT Title of Document:
ABSTRACT Title of Document:

... I have had the honor and privilege to work with many advisors and collaborators from the University of Maryland and the National Institutes of Health, all of whom have contributed to the successful completion of this dissertation. I am grateful for the support from my advisor, Dr. Nam Sun Wang, who ...
9th International Workshop on Clinical
9th International Workshop on Clinical

Extreme hyperinsulinemia unmasks insulin`s effect to stimulate
Extreme hyperinsulinemia unmasks insulin`s effect to stimulate

Drug
Drug

... 3) Rectal: used when it is unable to use oral ingestion such as unconscious patients or children. About 50% of the drug absorbed from the rectum will bypass the liver – less firstpass effect ...
Synthetic Biology
Synthetic Biology

... for several sequencing applications; optimization of cluster and cloud environments; development of new algorithms and procedures for NGS data analysis. Ongoing collaborations •Need to be ...
DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC
DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC

... has a plasma half-life of 3–4 hours, and peak concentrations of 8– 12 µg/ml are reached within 1–2 hours of the recommended daily dose of 600 mg in adults4. Rifampicin is quickly absorbed from the gastrointestinal tract with peak serum concentrations of 6-8 μg/ml occurring 1.5-2.0 hours after admini ...
Mosapride citrate
Mosapride citrate

... In a study in which mosapride citrate was administered to male rats at doses of 10, 100, or 1000 mg/kg/day po and to female rats at 3, 30, or 300 mg/kg/day po before gestation and in the early gestation period, no effects on fertility or fetal development were observed at 1000 mg/kg/day in male pare ...
Contrast Agent and Radiopharmaceutical Billing Codes Hospital
Contrast Agent and Radiopharmaceutical Billing Codes Hospital

... regardless of whether the items are paid separately or packaged, using the correct HCPCS codes for the items used. It is also of great importance that hospitals billing for these products make certain that the reported units of service of the reported HCPCS codes are consistent with the quantity of ...
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy

... Amoebiasis is an important public health problem in developing countries. Entamoeba histolytica, the causative agent of amoebiasis, may develop resistance to nitroimidazoles, a group of drugs considered to be the most effective against this parasitic disease. Therefore, research on new drugs for the ...
165 Regeneration of protochlorophyll in dark
165 Regeneration of protochlorophyll in dark

File
File

... is a β-blocking agent used widely in the treatment of hypertension (Heel et al, 1979). Atenolol is available as a conventional tablet. The tablet is taken twice or three times daily leading to fluctuations in plasma concentration and side effects such as fatigue, dizziness and cold extremities . Abs ...
BHF Factfile: The Use of Digoxin
BHF Factfile: The Use of Digoxin

... there are other effective treatments for heart failure, including ACE inhibitors, beta blockers and spironolactone, all of which reduce mortality. Furthermore, the DIG study, a large prospective randomized trial, showed that digoxin had no effect on mortality and only led to a small reduction in the ...
7. Multiple Testing
7. Multiple Testing

... this feature false-positive given its specific p-value ? ------------------------------Efron’s local FDR uses a mixture model and the empirical Bayes approach. An empirical null distribution is put in the place of the ...
Technical Article Recent Developments in Discontinuous Galerkin Methods for the Time–
Technical Article Recent Developments in Discontinuous Galerkin Methods for the Time–

... frequency is denoted by ω > 0. The real-valued functions µ, ε and σ are the magnetic permeability, electric permittivity, and electric conductivity, respectively. The origins of DG methods can be traced back to the seventies, where they were proposed for the numerical solution of the neutron transpo ...
Inappropriate sinus tachycardia — successful treatment with
Inappropriate sinus tachycardia — successful treatment with

Modelling the Gaia Hypothesis: Daisyworld
Modelling the Gaia Hypothesis: Daisyworld

... In the above rules, c is a constant value to help accelerate daisy growth. Before the addition of this constant the daisies were not able to grow fast enough to keep up with changing solar luminosity. This constant is currently set to 9. The spreading threshold helps avoid daisy growth being limited ...
< 1 ... 47 48 49 50 51 52 53 54 55 ... 157 >

Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
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