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Molecular Genetics - Madison County Schools
Molecular Genetics - Madison County Schools

...  Other proteins called single strand binding protein line up along the unpaired DNA, and hold the strands apart so that replication can proceed. ...
three possibile models for replication
three possibile models for replication

... 23. Replication is semiconservative… meaning each DNA strand in the original double helix serves as a template for a new complementary strand  each new double helix has one old (parent) strand and one new (daughter) strand. 24. The other two possible models (now known to be incorrect) are conservat ...
DNA REPLICATION Complexity of DNA
DNA REPLICATION Complexity of DNA

... The E. coli DNA polymerase III acts as a dimer, and each monomer consists of multiple subunits. One monomer acts in a continuous fashion on the leading template strand, while the other acts simultaneously on the lagging strand with the discontinuous formation of multiple Okazaki fragments that are s ...
Intro, show Jurassic Park, relate to all other units, Discuss history
Intro, show Jurassic Park, relate to all other units, Discuss history

... 4. taking the leading strand, DNA polymerase III can ONLY add to existing nucleotides (must be a union job) so someone has to start the first nucleotide or prime it. RNA primer, with a few RNA nucleotides, will bind to the old DNA. Of course, RNA primase will catalyze this reaction. 5. now DNA polym ...
8-DNA
8-DNA

... 21. The relationship between the sequences of bases in DNA and amino acids in protein would be best stated as: A. The sequence of nucleotides in DNA is determined by the amino acid sequence of DNA polymerase. B. The sequence of nucleotides in a DNA is determined by the amino acids in proteins. C. Th ...
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13.1 ws B

... expressed; exons are kept and put together to form mRNA ...
013368718X_CH20_313
013368718X_CH20_313

... expressed; exons are kept and put together to form mRNA ...
Chapter 16 - Molecular Basis of Inheritance DNA as the Genetic
Chapter 16 - Molecular Basis of Inheritance DNA as the Genetic

... 5’ end of new strand can’t be replicated • When it serves as a template, the resulting duplex is shorter Telomeres at Chromosome Ends Eukaryotic chromosome ends have special nucleotide sequences called telomeres TTAGGG sequence repeated 100-1000 times Protect genes near ends by preventing shortening ...
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DNA

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DNA - The Double Helix
DNA - The Double Helix

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12.1 and 12.2 Fill
12.1 and 12.2 Fill

... In DNA, there are four possible nitrogenous bases: ________ (A), guanine (G), cytosine (C), and thymine (T). Thus, in DNA there are four possible nucleotides, each containing one of these four bases. DNA Nucleotides Adenine and Guanine are in a group known as the ______________ (they are larger). Cy ...
Structure and function of DNA
Structure and function of DNA

... Using melting profile we can differentiate between single stranded and double stranded DNA. ...
Structure and function of DNA
Structure and function of DNA

... Using melting profile we can differentiate between single stranded and double stranded DNA. ...
REPLICATION OF GENETIC INFORMATION
REPLICATION OF GENETIC INFORMATION

... that is degradated and thus DNA will get shorter with each round of DNA replication cells normally can divide about 50 to 70 times *During cell division, you lose 30-200 bp from telomeres end (length of telomeres 8,000 bp at birth to 1,500 in old people) ...
Assembly of Mutant-Template Telomerase RNA into Catalytically
Assembly of Mutant-Template Telomerase RNA into Catalytically

... The telomerase ribonucleoprotein is a promising target for cancer therapy, as it is highly active in many human malignancies. A novel telomerase targeting approach combines short interfering RNA (siRNA) knockdown of endogenous human telomerase RNA (hTer) with expression of a mutant-template hTer (MT ...
DNA - Science-with
DNA - Science-with

...  in DNA  the amount of adenine is always approximately equal to the amount of thymine (A ~ T)  the amount of cytosine is always approximately equal to the amount guanine. (C ~ G) ...
BIOL 222 - philipdarrenjones.com
BIOL 222 - philipdarrenjones.com

... chromosomes have many. C) The rate of elongation during DNA replication is slower in prokaryotes than in eukaryotes. D) Prokaryotes produce Okazaki fragments during DNA replication, but eukaryotes do not. E) Prokaryotes have telomeres, and eukaryotes do not 7) Alternative splicing is a term that des ...
2008 Topic 3 and 7 Test BANK
2008 Topic 3 and 7 Test BANK

... 13. In the above diagram of the process of DNA replication at a replication fork, the strand labeled B is the: A template strand B lagging strand C leading strand D Okazaki fragment E RNA primer 14. In the above diagram of the process of DNA replication at a replication fork, the black boxes labeled ...
Lec. 2 - DNA replication 1
Lec. 2 - DNA replication 1

... Then, Pol I degrades the RNA part with its 5’-3’ exonuclease activity, and replaces it with DNA. Pol I is not highly processive, so stops before going far. ...
Basics of DNA Replication
Basics of DNA Replication

... N DNA. These ...
chapter 16 – the molecular basis of inheritance
chapter 16 – the molecular basis of inheritance

... radioactive emissions, X-rays, UV light, spontaneous chemical changes of the DNA molecule. ...
What should I study for the test
What should I study for the test

... 7. What molecule attaches to each the 1’, 3’ and 5’ carbons of this sugar to form a DNA nucleotide? 1’ attaches to a nitrogenous base (A, T, C or G) and the 3’ and 5’ attach to phosphate groups (phosphoric acids) 8. What four nitrogenous bases are found in DNA? Adenine, Thymine, Cytosine, and Guani ...
Questions 4
Questions 4

... 2. Why, specifically, are the 5’-phosphate and the 3’-hydroxyl groups of a deoxyribonucleotide absolutely necessary for DNA synthesis? The drug AZT is a triphosphate form of a deoxyribonucleotide with an azide group (-N3) at the 3’position. What function would it have in terms of slowing HIV infecti ...
Molecular Bio Questions1
Molecular Bio Questions1

... 2. Why, specifically, are the 5’-phosphate and the 3’-hydroxyl groups of a deoxyribonucleotide absolutely necessary for DNA synthesis? The drug AZT is a triphosphate form of a deoxyribonucleotide with an azide group (-N3) at the 3’position. What function would it have in terms of slowing HIV infecti ...
PowerPoint Notes on Chapter 9
PowerPoint Notes on Chapter 9

... The Rate of Replication Replication does not begin at one end of the DNA molecule and end at the other. The circular DNA molecules found in prokaryotes usually have two replication forks that begin at a single point. The replication forks move away from each other until they meet on the opposite sid ...
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Telomere



A telomere is a region of repetitive nucleotide sequences at each end of a chromatid, which protects the end of the chromosome from deterioration or from fusion with neighboring chromosomes. Its name is derived from the Greek nouns telos (τέλος) 'end' and merοs (μέρος, root: μερ-) 'part.' For vertebrates, the sequence of nucleotides in telomeres is TTAGGG. This sequence of TTAGGG is repeated approximately 2,500 times in humans. During chromosome replication, the enzymes that duplicate DNA cannot continue their duplication all the way to the end of a chromosome, so in each duplication the end of the chromosome is shortened (this is because the synthesis of Okazaki fragments requires RNA primers attaching ahead on the lagging strand). The telomeres are disposable buffers at the ends of chromosomes which are truncated during cell division; their presence protects the genes before them on the chromosome from being truncated instead.Over time, due to each cell division, the telomere ends become shorter. They are replenished by an enzyme, telomerase reverse transcriptase.
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