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... Various studies provide evidence that equianalgesic doses of pethidine cause similar effects on the sphincter of Oddi and the biliary tract to other opioids. All opioids have been found to increase biliary tract pressure 1, which may result in spasm of the sphincter of Oddi, leading to epigastric di ...
Cocaine - Computer Science
Cocaine - Computer Science

... drug users during real-life drug use events. These data provide a first look at physiological response to drug use episodes of up to 600 mg. Second, this work shows that it is indeed possible to develop a model for detection of health events from physiological sensor data collected in the lab settin ...
Review and Recommendations for Drug Testing in Substance Use
Review and Recommendations for Drug Testing in Substance Use

... Drug use implications and the role of testing Drug and alcohol use have been associated with substantial impairments in functioning in a number of settings including driving [1], the work place [2], family functioning [3] and military service [4, 5]. In the United States alone it is estimated that 2 ...
DH 250 - Cypress College
DH 250 - Cypress College

... the following manner: ...
Medication used in the Treatment of Parkinson`s
Medication used in the Treatment of Parkinson`s

... important to bear in mind when referring to the booklet that no two people with Parkinson’s are exactly the same, and each will have a different combination of symptoms and medication. In this booklet the type of drug appears as the section heading, the drug is then listed according to the generic n ...
Enhancement of Excessive Lever-Pressing After Post
Enhancement of Excessive Lever-Pressing After Post

... as an anxiety disorder characterized by obsessive thinking and compulsive behavior. A major characteristic of obsessions and compulsions is that they are excessive and unreasonable. However, both obsessions and compulsions (e.g., doubting, checking, or washing) may be viewed as an exaggeration of no ...
Slide 1 - The University of Sydney
Slide 1 - The University of Sydney

... • Describe the mechanism of action, pharmacology • Describe its desired and undesired effects • Describe the therapeutic uses of cannabis • Describe the prevalence of cannabis use • Assess cannabis use clinically, predisposing factors, and associated harms • Understand the management of cannabis use ...
NIZORAL 200 MG TABLETS
NIZORAL 200 MG TABLETS

... outcome or requiring liver transplantation have occurred with the use of oral ketoconazole (see section 4.8 Undesirable effects). Some patients had no obvious risk factors for liver disease. Cases have been reported that occurred within the first month of treatment, including some within the first w ...
Guidelines on Choice and Selection of Antipsychotics
Guidelines on Choice and Selection of Antipsychotics

... Individual patient response can however vary. Antipsychotics also have important differences in the side-effects they cause. Patients differ in the side-effects they experience and the side-effects they are willing or not willing to tolerate. Antipsychotics are most effective in ameliorating positiv ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights

... amphetamine sulfate extended-release capsules are indicated for the treatment of attention deficit hyperactivity disorder (ADHD). The efficacy of dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate, amphetamine sulfate extended-release in the treatment of ADHD ...
Substance use disorders: treatment with genetic potential?
Substance use disorders: treatment with genetic potential?

... (b) Difficulty in controlling substance use, such as: onset, termination, or quantity; (c) Withdrawal symptoms based on the type of drug used, including the use of the same/similar substance to relieve/circumvent withdrawal symptoms; (d) Tolerance, such that increased doses are required to achieve t ...
Tobacco Use - The Citadel
Tobacco Use - The Citadel

... The problem with all this is that “ safer” doesn’t mean “ safe,” and it wasn’t at all clear how much safer these low tar and nicotine cigarettes actually are for people over a life-time of smoking. A major blow to the “ healthier cigarette” notion was dealt in 2006 when the U. S. Government obtained ...
Corticotropin-releasing factor-1 receptor activation mediates nicotine
Corticotropin-releasing factor-1 receptor activation mediates nicotine

... nicotine-seeking was mediated via the activation of CRF1 or CRF2 receptors. Substantial evidence suggests that CRF1 receptors play a role in alcohol and nicotine withdrawal-induced anxiety-like behavior and alcohol and nicotine intake in dependent animals (23–25).Conflicting findings have been repor ...
Indole alkaloids
Indole alkaloids

... labour to assist delivery and to reduce post-partum hemorrhage, ergot itself has been largely replaced in the pharmacopoeias by the isolated alkaloids. Only ergometrine produces an oxytocic effect ergotoxine and ergotamine having quite a different action. Ergometrine is soluble in water or in dilute ...
the concept of the therapeutic window in the choice of h1
the concept of the therapeutic window in the choice of h1

... tion. By contrast, the upper limit is set by the highest dose tolerated without adverse pharmacologic effect. The therapeutic window will differ between intranasal (topical) and oral (systemic) drug administration. The issues discussed in this paper will focus on those pertaining to oral H1-antihist ...
Subutex - A Prisoners Guide. Lifeline Publications
Subutex - A Prisoners Guide. Lifeline Publications

... has become the number one drug of choice. The prison service are aware of this and are about to step up their response. At present sniffer dogs are being trained so they can detect buprenorphine and it is likely testing for it will become far more widespread. The main drug test for buprenorphine is ...
High Court Judgment Template
High Court Judgment Template

... or predominantly hyperactive-impulsive ADHD, as appropriate. Most people exhibit the listed symptoms to some degree and therefore an ADHD diagnosis requires that they are present to a severe degree and cause impairment in more than one setting. ...
Pharmacological Evaluation of Saraca indica Leaves for Central
Pharmacological Evaluation of Saraca indica Leaves for Central

... membrane hyperpolarization which leads to decreased in activity. a decrease in the firing rate of critical Discussion and Conclusion: neurons in the brain or may be due to direct This study has established the central activation of GABA receptor by the extracts nervous system depressant properties o ...
P-RMS
P-RMS

... Concomitant treatment with alpha-antagonists may produce or aggravate hypotension. The combination of diltiazem with an alpha-antagonist should be considered only with the strict monitoring of the blood pressure. Amiodarone, digoxin: Increased risk of bradycardia: Caution is required when these are ...
Suppression of Noxious Stimulus-Evoked Activity in the Ventral
Suppression of Noxious Stimulus-Evoked Activity in the Ventral

... The spinothalamic tract plays an integral role in the transmission of nociceptive information from the spinal to supraspinal level (Mitchell and Hellon, 1977; Guilbaud et al., 1980; Peschanski et al., 1980a,b, 1983) (for review, see Willis, 1984). Originating primarily in the dorsal horn of the spin ...
Viewpoint:  untoward  effects  of  beta-adrenoceptor J.
Viewpoint: untoward effects of beta-adrenoceptor J.

... obstruction in man or in animals subjected to bronchoconstrictor stimuli. These observations implied that betaadrenoceptor agonists could cause relaxation of airway smooth muscle in asthma, which clinical investigation proved to be correct. Nonetheless, there have been intermittent reports of a wors ...
Topical Glucocorticoids – A Review
Topical Glucocorticoids – A Review

... effects of these drugs by virtue of the decreased blood flow to the inflamed site. Additionally it is this blanching response which forms the basis of the standard assay for the assessment of the potency of topical Glucocorticoids. Mechanisms of Anti Inflammatory Action of the Topical Glucocorticoid ...
Stevens Johnson Syndrome
Stevens Johnson Syndrome

... reports of SJS and TEN, which represents slightly more than exposed to propionic acids were significantly younger than 10% of all cases in the FDA database we analyzed. For all cases exposed to other types of NSAID (mean age 39 vs 54 10 of these NSAID, the NAMCS estimates exceeded yrs; p < 0.01). Th ...
Antidepressant medication table for Adults
Antidepressant medication table for Adults

... *This list includes a variety of drugs with side effects and act by different neurotransmitter mechanisms. The Lancet (1) concluded that sertraline offers the best balance among efficacy, acceptability, and costs compared to 11 other agents. Contraindications: Use of many antidepressants is contrain ...
Facts about Buprenorphine (Suboxone )  ®
Facts about Buprenorphine (Suboxone )  ®

... severe headaches are occasionally reported and  moderate headaches are common during the first  few days of induction.  • Taking large doses of methadone can cause and  has caused deaths; taking large doses of  buprenorphine is much less likely to cause  overdose and possible death if it’s the only  ...
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Stimulant



Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.
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