... As Table 1 shows, GHB (225 and 250 mg/kg) provoked a marked but short lasting catalepsy with a peak of action within 30 min. However, 60 min after GHB administration this cataleptic effect had disappeared. These results are in concordance with a recent study using male mice in which a dose-dependent ...
Interactive Properties of Tizanidine (Zanaflex)
... In a randomized controlled study of healthy subjects, pretreatment with fluvoxamine (100 mg/day for 4 days) resulted in a dramatic 33-fold increase in tizanidine area under the plasma concentration–time curve (AUC).1 The marked increases in tizanidine plasma concentrations were accompanied by pharma ...
... In a randomized controlled study of healthy subjects, pretreatment with fluvoxamine (100 mg/day for 4 days) resulted in a dramatic 33-fold increase in tizanidine area under the plasma concentration–time curve (AUC).1 The marked increases in tizanidine plasma concentrations were accompanied by pharma ...
The Socio-Economic Impact of Amphetamine Type Stimulants in
... triggering any violent defensive or self-harm response. Methamphetamine users’ increased propensity for self-harm should also be taken into account when they are detained in custody. ...
... triggering any violent defensive or self-harm response. Methamphetamine users’ increased propensity for self-harm should also be taken into account when they are detained in custody. ...
Cocaine and Alcohol Interactions in Humans
... participation in the study. Mean age, body weight and height were 27 years (range 25–30), 69.6 kg (range 64.0–77.6) and 176 cm (range 161–184), respectively. Their average consumption of alcohol was 44 g/day, and their average use of cocaine by the intranasal route was between once and twice per mon ...
... participation in the study. Mean age, body weight and height were 27 years (range 25–30), 69.6 kg (range 64.0–77.6) and 176 cm (range 161–184), respectively. Their average consumption of alcohol was 44 g/day, and their average use of cocaine by the intranasal route was between once and twice per mon ...
Ivermectin fact sheet
... toxicity in neonatal rodents [12], perhaps because P-glycoprotein protein expression in brain capillary cells is incomplete until postnatal day 21 [13]. Surprisingly, ivermectin did not alter seizure responses in either seizure-prone or seizure-resistant mice [14]. ...
... toxicity in neonatal rodents [12], perhaps because P-glycoprotein protein expression in brain capillary cells is incomplete until postnatal day 21 [13]. Surprisingly, ivermectin did not alter seizure responses in either seizure-prone or seizure-resistant mice [14]. ...
... an initial step toward filling this gap. The results of this study suggest that salvia use is most common among young adults aged 18–25 years as well as individuals who had engaged in risk-taking behaviors (selling illicit drugs, stealing) or illicit drug use (especially other hallucinogens/ecstasy) ...
NSAID use in Athletes
... • Judicious short-term uses of NSAIDS, with consideration of the specific type of injury, level of dysfunction, and pain, may be useful in the management of acute ligament sprains, muscle strains, tendinitis, and eccentric muscle injury ...
... • Judicious short-term uses of NSAIDS, with consideration of the specific type of injury, level of dysfunction, and pain, may be useful in the management of acute ligament sprains, muscle strains, tendinitis, and eccentric muscle injury ...
Serotonergic Manipulations Both Potentiate and Reduce Brain
... bens or the caudate-putamen decreased BSR (Bose et al., 1974; Redgrave, 1978; McClelland et al., 1989; Lee and Kornetsky, 1998). The above-mentioned studies used rats with stimulating electrodes in the medial forebrain bundle, including the area of the lateral hypothalamus. However, studies in subje ...
... bens or the caudate-putamen decreased BSR (Bose et al., 1974; Redgrave, 1978; McClelland et al., 1989; Lee and Kornetsky, 1998). The above-mentioned studies used rats with stimulating electrodes in the medial forebrain bundle, including the area of the lateral hypothalamus. However, studies in subje ...
Case History - Children`s Hospital of Michigan
... and the effect or plateau that they are attempting to achieve. The recommended therapeutic dose for DXM is 10-20 mg every 4 hours or 30 mg every 6-8 hours. There are traditionally four plateaus achieved based on the amount of DXM ingested. Users will consume 600 mg to achieve the second plateau. Mos ...
... and the effect or plateau that they are attempting to achieve. The recommended therapeutic dose for DXM is 10-20 mg every 4 hours or 30 mg every 6-8 hours. There are traditionally four plateaus achieved based on the amount of DXM ingested. Users will consume 600 mg to achieve the second plateau. Mos ...
The Development of Context-specific Operant Sensitization to d
... If sensitization develops, then less of a drug is needed to produce the original effects of the drug. Tolerance has been shown to be one process involved in the development of drug addiction. Tolerance can result in more of a drug being needed to achieve the same initial effect. Tolerance can either ...
... If sensitization develops, then less of a drug is needed to produce the original effects of the drug. Tolerance has been shown to be one process involved in the development of drug addiction. Tolerance can result in more of a drug being needed to achieve the same initial effect. Tolerance can either ...
PDF full-Text - Journal of Investigational Allergology and Clinical
... this transport system [11]. Drugs or substances that are able to induce PgP, such as rifampicin, yield a lesser concentration of fexofenadine when co-administered with the latter drug; pharmacological interaction therefore exists in this case. The result of this interaction is a decrease in fexofena ...
... this transport system [11]. Drugs or substances that are able to induce PgP, such as rifampicin, yield a lesser concentration of fexofenadine when co-administered with the latter drug; pharmacological interaction therefore exists in this case. The result of this interaction is a decrease in fexofena ...
Psychiatric Prescribing in College Health: Anxiety and
... distinguishing them from conditions that require different treatment Medication for anxiety – SSRI’s, benzodiazepines, other drugs Treatment tips & when to refer ...
... distinguishing them from conditions that require different treatment Medication for anxiety – SSRI’s, benzodiazepines, other drugs Treatment tips & when to refer ...
Asthma Medications
... The frequency of initial oral use may be as often as 3-4 times per day for 1-2 days following an acute asthma attack, which is then slowly decreased over 1 week. When corticosteroids are taken regularly, they should be taken once daily upon awakening (usually in the morning) to coincide with your bo ...
... The frequency of initial oral use may be as often as 3-4 times per day for 1-2 days following an acute asthma attack, which is then slowly decreased over 1 week. When corticosteroids are taken regularly, they should be taken once daily upon awakening (usually in the morning) to coincide with your bo ...
... Quijada, 1989). In contrast, there are few reports in relation to the effects of chronic administration of sulpiride on body weights in males, and most of these studies have used low doses of the drug. Thus, Baptista et al. (1987) found that chronic administration of sulpiride for 21 days (10 or 20 ...
The H2 Blockers` Rx-to OTC Switch: For Whom Will It Spell Relief
... certain conditions are met, as many as five extra years on the term of one of a drug’s patents.23 This part of the law compensates the company for the time lost on its patent while the drug went through the testing and regulatory phase. Because of the requirements for a patent extension, it will be ...
... certain conditions are met, as many as five extra years on the term of one of a drug’s patents.23 This part of the law compensates the company for the time lost on its patent while the drug went through the testing and regulatory phase. Because of the requirements for a patent extension, it will be ...
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... desire leading to sex crimes such as sexual assault and child sexual abuse. Molecular Targets: Serotonin (5-HT) and Dopamine (DA) - Low levels of 5-HT in the raphe nuclei are correlated with increased sexual desire - High levels of DA in the hypothalamus, prefrontal cortex (PFC), and ventral tegment ...
... desire leading to sex crimes such as sexual assault and child sexual abuse. Molecular Targets: Serotonin (5-HT) and Dopamine (DA) - Low levels of 5-HT in the raphe nuclei are correlated with increased sexual desire - High levels of DA in the hypothalamus, prefrontal cortex (PFC), and ventral tegment ...
Panel Discussion 3 Questions
... 21. Data from Monitoring the Future 2004 suggest that over 35% of 12th graders in high school report using marijuana in the past 12 months. Is there such a thing as healthy experimentation? Is there proof that marijuana is psychologically or physically addictive? 22. Should smoking and possession of ...
... 21. Data from Monitoring the Future 2004 suggest that over 35% of 12th graders in high school report using marijuana in the past 12 months. Is there such a thing as healthy experimentation? Is there proof that marijuana is psychologically or physically addictive? 22. Should smoking and possession of ...
Antihistamine Toxicosis
... into milk. Cetirizine is also know to undergo low degree of first-pass metabolism in the liver, so individuals with a history of a liver disease may metabolize Piperazine-derivative antihistamines differently than normal individuals do. 5 The first-generation Piperazine-derivative antihistamines ar ...
... into milk. Cetirizine is also know to undergo low degree of first-pass metabolism in the liver, so individuals with a history of a liver disease may metabolize Piperazine-derivative antihistamines differently than normal individuals do. 5 The first-generation Piperazine-derivative antihistamines ar ...
Prescribing for Pregnant or Lactating Women
... • Clinical information concerning the safety of drug use while breast-feeding an infant is often more limited than information regarding the safe use of drugs during pregnancy. ...
... • Clinical information concerning the safety of drug use while breast-feeding an infant is often more limited than information regarding the safe use of drugs during pregnancy. ...
Non-Clinical Investigation of the Dependence Potential of Medicinal
... The choice of the model used should be justified based on the biochemical, pharmacological and clinical information already available. Pharmaceutical, pharmacokinetic and physico-chemical characteristics of the product may also influence the choice of the model. Specific aspects of dependence potent ...
... The choice of the model used should be justified based on the biochemical, pharmacological and clinical information already available. Pharmaceutical, pharmacokinetic and physico-chemical characteristics of the product may also influence the choice of the model. Specific aspects of dependence potent ...
The Effect of Alcohol on Brain Reward
... neurochemical changes that persist into adult life; … provide a model for some of the clinical observations in cocaine-exposed children, especially state or contextdependent differences; and … demonstrate changes in dopamine release in the nucleus accumbens that correlate directly with changes seen ...
... neurochemical changes that persist into adult life; … provide a model for some of the clinical observations in cocaine-exposed children, especially state or contextdependent differences; and … demonstrate changes in dopamine release in the nucleus accumbens that correlate directly with changes seen ...
Non-medical use of olanzapine by people on methadone treatment
... lifetime history of NMU of olanzapine. They did not differ significantly from those without a history of use in terms of gender, age or duration of methadone treatment. Of participants reporting a lifetime history of NMU of olanzapine, two reported currently being prescribed this medication and only ...
... lifetime history of NMU of olanzapine. They did not differ significantly from those without a history of use in terms of gender, age or duration of methadone treatment. Of participants reporting a lifetime history of NMU of olanzapine, two reported currently being prescribed this medication and only ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.