Analysis of submissions: Proposal to Classify
... regulation of “restricted substances”, substances that are considered to be deserving of control, but not outright prohibition. This reflected the framework the EACD had indicated in its March 2004 report might be an alternative to an outright ban for BZP and other substances. BZP was classified as ...
... regulation of “restricted substances”, substances that are considered to be deserving of control, but not outright prohibition. This reflected the framework the EACD had indicated in its March 2004 report might be an alternative to an outright ban for BZP and other substances. BZP was classified as ...
Gamma-butyrolactone (GBL) - World Health Organization
... GBL is faster than GHB, its potency greater, and its duration of activity longer, its abuse potential may actually be greater than GHB itself. There is a steep dose-effect curve between doses producing desired and excessive effects, and there have been numerous published reports of adverse reactions ...
... GBL is faster than GHB, its potency greater, and its duration of activity longer, its abuse potential may actually be greater than GHB itself. There is a steep dose-effect curve between doses producing desired and excessive effects, and there have been numerous published reports of adverse reactions ...
Fear Conditioning
... a. D1 antagonist blocks NPS self-administration b. D1 antagonist SCH 23390 also blocks NPS stimulated locomotion 4. NPS → NPSR → ↑ DMH/PF → ↑ Orx activity 5. Orx1 receptor antagonist blocks NPS self-administration a. Orx1 antagonist SB 334867 has no effect on locomotion 6. NPS at a high 1,000 pmol d ...
... a. D1 antagonist blocks NPS self-administration b. D1 antagonist SCH 23390 also blocks NPS stimulated locomotion 4. NPS → NPSR → ↑ DMH/PF → ↑ Orx activity 5. Orx1 receptor antagonist blocks NPS self-administration a. Orx1 antagonist SB 334867 has no effect on locomotion 6. NPS at a high 1,000 pmol d ...
The Eclectic Materia Medica, Pharmacology and Therapeutics by
... inflammation follows, but in rarely susceptible cases vesicular or pustular eruptions take place, or intense cutaneous itching. Both are extremely irritating to the nasal and ocular membranes, and when inhaled may give rise to a peculiar local sense of icy-coldness. Administered internally in small ...
... inflammation follows, but in rarely susceptible cases vesicular or pustular eruptions take place, or intense cutaneous itching. Both are extremely irritating to the nasal and ocular membranes, and when inhaled may give rise to a peculiar local sense of icy-coldness. Administered internally in small ...
Zolpidem Physical Dependence Assessed Across Increasing Doses
... 1993), which indicated that the baboons may have become physically dependent on zolpidem. Mild to intermediate withdrawal symptoms (including tremor, jerk, nausea and abdominal pain) have been reported in patients treated for insomnia with high doses of zolpidem (Cavallaro et al., 1993). Thus, the e ...
... 1993), which indicated that the baboons may have become physically dependent on zolpidem. Mild to intermediate withdrawal symptoms (including tremor, jerk, nausea and abdominal pain) have been reported in patients treated for insomnia with high doses of zolpidem (Cavallaro et al., 1993). Thus, the e ...
Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5
... hydrochloride are contraindicated in patients with anatomically narrow angles or narrow angle glaucoma. Phenylephrine hydrochloride may be contraindicated in low birth weight infants and in some elderly adults with severe arteriosclerotic cardiovascular or cerebrovascular disease. Phenylephrine hydr ...
... hydrochloride are contraindicated in patients with anatomically narrow angles or narrow angle glaucoma. Phenylephrine hydrochloride may be contraindicated in low birth weight infants and in some elderly adults with severe arteriosclerotic cardiovascular or cerebrovascular disease. Phenylephrine hydr ...
Print - Circulation
... myocardial K⫹ and H⫹ homeostasis. Inhibition of H⫹/K⫹ATPase might therefore induce cellular acidosis, which is known to depress myocardial contractility mainly at the level of myofilament responsiveness to [Ca]i.9 Orally applied PPIs are considered safe1 and have been found advantageous in regard to ...
... myocardial K⫹ and H⫹ homeostasis. Inhibition of H⫹/K⫹ATPase might therefore induce cellular acidosis, which is known to depress myocardial contractility mainly at the level of myofilament responsiveness to [Ca]i.9 Orally applied PPIs are considered safe1 and have been found advantageous in regard to ...
Dextromethorphan Pre
... tablet, spray, and lozenge forms. In its pure form, dextromethorphan occurs as a white powder. Dextromethorphan is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is as an NMDA receptor antagonist ...
... tablet, spray, and lozenge forms. In its pure form, dextromethorphan occurs as a white powder. Dextromethorphan is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is as an NMDA receptor antagonist ...
Full Text
... epilepsy. Zebrafish with a mutation in scn1Lab recapitulate salient phenotypes associated with DS, including seizures, early fatality, and resistance to antiepileptic drugs. To discover new drug candidates for the treatment of DS, we screened a chemical library of ⬃1000 compounds and identified 4 co ...
... epilepsy. Zebrafish with a mutation in scn1Lab recapitulate salient phenotypes associated with DS, including seizures, early fatality, and resistance to antiepileptic drugs. To discover new drug candidates for the treatment of DS, we screened a chemical library of ⬃1000 compounds and identified 4 co ...
PDF - Pharmacological Reviews
... A. An approach of merging the mass-action law with mathematical induction and deduction . . 1. The power of mathematical induction and deduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. Nature’s law . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
... A. An approach of merging the mass-action law with mathematical induction and deduction . . 1. The power of mathematical induction and deduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. Nature’s law . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
Ewrramt~amm=nts I
... But another type of aspirin-antacid combination tablet may reduce stomach damage. Some aspinn products are enteric-coated. This prevents the aspirin tablet from dissolving until it reaches the intestines. The intestinal walls are less likely to be harmed by aspirin, presumably because they are more ...
... But another type of aspirin-antacid combination tablet may reduce stomach damage. Some aspinn products are enteric-coated. This prevents the aspirin tablet from dissolving until it reaches the intestines. The intestinal walls are less likely to be harmed by aspirin, presumably because they are more ...
[Product Monograph Template
... nursing mothers have shown that naloxone does not affect prolactin or oxytocin hormone levels. Pediatrics: An accidental opioid exposure is possible in the pediatric population. Naloxone administration may cause an acute opioid withdrawal syndrome which may be life threatening in opioid dependent ne ...
... nursing mothers have shown that naloxone does not affect prolactin or oxytocin hormone levels. Pediatrics: An accidental opioid exposure is possible in the pediatric population. Naloxone administration may cause an acute opioid withdrawal syndrome which may be life threatening in opioid dependent ne ...
2009 St Johns Wort Quality Issues and Active Compounds
... provides suffi cient quantitative data about the amount of fl avonoids in the different SJW extracts, unfortunately no quantitative data are given for hypericin and hyperforin. Nevertheless, the experiments show that the phar-macological effects of an extract cannot directly be compared with the eff ...
... provides suffi cient quantitative data about the amount of fl avonoids in the different SJW extracts, unfortunately no quantitative data are given for hypericin and hyperforin. Nevertheless, the experiments show that the phar-macological effects of an extract cannot directly be compared with the eff ...
Adenine Nucleotides Undergo Rapid, Quantitative Conversion to
... The existence in brain of multiple subtypes of extracellular adenosine receptors, physiological responses linked to activation of those receptors, the normal presence of adenosine in the extracellular space, and the marked increases in adenosine that can occur under various conditions (e.g., hypoxia ...
... The existence in brain of multiple subtypes of extracellular adenosine receptors, physiological responses linked to activation of those receptors, the normal presence of adenosine in the extracellular space, and the marked increases in adenosine that can occur under various conditions (e.g., hypoxia ...
Clinical pharmacology and abuse potential of gamma‐hydroxybutyric acid (GHB)
... psychomotor performance induced by GHB in humans. Few studies addressed dose‐related effects under controlled administration and the correlation of drug effects and concentrations in biological fluids including alternative matrices. Furthermore, although GHB was being abused by humans, ...
... psychomotor performance induced by GHB in humans. Few studies addressed dose‐related effects under controlled administration and the correlation of drug effects and concentrations in biological fluids including alternative matrices. Furthermore, although GHB was being abused by humans, ...
GHB, GBL and 1,4-BD Addiction - Trimbos
... The virtual absence of abuse liability of GHB in clinical trails of narcolepsy patients or alcoholics remains a challenging issue [4, 74, 75]. Approximately, only one case for every 2,600 narcolepsy patients treated fulfilled DSM-IV criteria for substance abuse [76]. There could be a number of possi ...
... The virtual absence of abuse liability of GHB in clinical trails of narcolepsy patients or alcoholics remains a challenging issue [4, 74, 75]. Approximately, only one case for every 2,600 narcolepsy patients treated fulfilled DSM-IV criteria for substance abuse [76]. There could be a number of possi ...
Salvia divinorum and Salvinorin A: An Update on Pharmacology and
... olism of salvinorin A or of other compounds in the plant that exhibit an antidepressant activity. If salvinorin A is metabolized to an either active or inactive metabolite, then the binding affinity and the pharmacological profile studied in vitro are at jeopardy. A further study evaluated the effec ...
... olism of salvinorin A or of other compounds in the plant that exhibit an antidepressant activity. If salvinorin A is metabolized to an either active or inactive metabolite, then the binding affinity and the pharmacological profile studied in vitro are at jeopardy. A further study evaluated the effec ...
Addictiveness and Attractiveness of Tobacco Additives
... been asked to evaluate the role of tobacco additives in the addictiveness and attractiveness of tobacco products. The criteria for dependence established in humans indicate that tobacco has a high addictive potential, but it remains difficult to assess the addictiveness of individual additives. In a ...
... been asked to evaluate the role of tobacco additives in the addictiveness and attractiveness of tobacco products. The criteria for dependence established in humans indicate that tobacco has a high addictive potential, but it remains difficult to assess the addictiveness of individual additives. In a ...
pdf 53Kb - NSW Bureau of Crime Statistics and Research
... anabolic steroid), when combined with strength training, significantly increased muscle mass and strength in normal men.3 The weekly doses of 600mg were six times greater than the doses usually given to men to treat hypogonadism, and are the highest administered for any study of athletic performance ...
... anabolic steroid), when combined with strength training, significantly increased muscle mass and strength in normal men.3 The weekly doses of 600mg were six times greater than the doses usually given to men to treat hypogonadism, and are the highest administered for any study of athletic performance ...
aspartate Antagonists on a Multiple Schedule of Ethanol and
... Many studies have examined drug effects on ethanol selfadministration behavior; however, relatively few experiments have attempted to assess the selectivity of pretreatment drug effects for ethanol self-administration, compared with other reinforcers. Clearly, pharmacologically useful treatment drug ...
... Many studies have examined drug effects on ethanol selfadministration behavior; however, relatively few experiments have attempted to assess the selectivity of pretreatment drug effects for ethanol self-administration, compared with other reinforcers. Clearly, pharmacologically useful treatment drug ...
ibogaine: a review
... withdrawal (22). Additional patents follow for indications of dependence on cocaine and other stimulants (23), alcohol (25), nicotine (26), and polysubstance abuse (27). 1988-1994: U.S. and Dutch researchers publish initial findings suggestive of the efficacy of ibogaine in animal models of addictio ...
... withdrawal (22). Additional patents follow for indications of dependence on cocaine and other stimulants (23), alcohol (25), nicotine (26), and polysubstance abuse (27). 1988-1994: U.S. and Dutch researchers publish initial findings suggestive of the efficacy of ibogaine in animal models of addictio ...
diamorphine hydrochloride bp 5 mg lyophilisate for solution for
... Diamorphine has been used in the treatment of terminally ill children. Diamorphine has been administered in reduced doses to children with neoplastic disease when it becomes difficult to give treatment orally. The starting dose should be selected according to age, size, symptoms and previous analges ...
... Diamorphine has been used in the treatment of terminally ill children. Diamorphine has been administered in reduced doses to children with neoplastic disease when it becomes difficult to give treatment orally. The starting dose should be selected according to age, size, symptoms and previous analges ...
Prescribing Framework for Phenelzine (MAOI) in the treatment of
... Once a patient’s mental state and medication have been stabilised they may be considered suitable for shared care between the specialist and GP. 3. Dose 15 mg 3 times daily, increased if necessary to 4 times daily after 2 weeks (hospital patients, max. 30 mg 3 times daily), then reduced gradually to ...
... Once a patient’s mental state and medication have been stabilised they may be considered suitable for shared care between the specialist and GP. 3. Dose 15 mg 3 times daily, increased if necessary to 4 times daily after 2 weeks (hospital patients, max. 30 mg 3 times daily), then reduced gradually to ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.