Statins - Amazon Web Services
... 607 000 lives, translating into about 1 out of every 5 deaths in the United States.1 High levels of cholesterol, or hypercholesterolemia, are an important risk factor for coronary heart disease. The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase inhibitors, also known as statins, are the mo ...
... 607 000 lives, translating into about 1 out of every 5 deaths in the United States.1 High levels of cholesterol, or hypercholesterolemia, are an important risk factor for coronary heart disease. The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase inhibitors, also known as statins, are the mo ...
Print - Circulation
... cardiac contractility has not been assessed directly. Methods and Results—Under physiological conditions (37°C, pH 7.35, 1.25 mmol/L Ca2⫹), there was a dose-dependent decrease in contractile force in ventricular trabeculae isolated from end-stage failing human hearts superfused with pantoprazole. Th ...
... cardiac contractility has not been assessed directly. Methods and Results—Under physiological conditions (37°C, pH 7.35, 1.25 mmol/L Ca2⫹), there was a dose-dependent decrease in contractile force in ventricular trabeculae isolated from end-stage failing human hearts superfused with pantoprazole. Th ...
Methamphetamine - Department of Electrical Engineering
... Although only the D-Isomer of selegiline will metabolize into active metabolites, both isomers may cause a positive result for methamphetamine and amphetamine on a drug test, in certain cases.[58] It is excreted by the kidneys, with the rate of excretion into the urine heavily influenced by urinary ...
... Although only the D-Isomer of selegiline will metabolize into active metabolites, both isomers may cause a positive result for methamphetamine and amphetamine on a drug test, in certain cases.[58] It is excreted by the kidneys, with the rate of excretion into the urine heavily influenced by urinary ...
View Full Article - PDF - International Research Journals
... the oral absorption of vancomycin and teicoplanin is very low so they must be administered intravenously to control systemic infections, which is not the preferred route of administration for many patients (Andre et al., 2010). Oxazolidinones are a novel class of synthetic antimicrobials with potent ...
... the oral absorption of vancomycin and teicoplanin is very low so they must be administered intravenously to control systemic infections, which is not the preferred route of administration for many patients (Andre et al., 2010). Oxazolidinones are a novel class of synthetic antimicrobials with potent ...
QUINIDINE GLUCONATE INJECTION, USP
... Quinidine clearance typically proceeds at 3-5 mL/min/kg in adults, but clearance in pediatric patients may be twice or three times as rapid. The elimination half-life is about 6-8 hours in adults and 3-4 hours in pediatric patients. Quinidine clearance is unaffected by hepatic cirrhosis, so the incr ...
... Quinidine clearance typically proceeds at 3-5 mL/min/kg in adults, but clearance in pediatric patients may be twice or three times as rapid. The elimination half-life is about 6-8 hours in adults and 3-4 hours in pediatric patients. Quinidine clearance is unaffected by hepatic cirrhosis, so the incr ...
Third Amended Master Consolidated Class Action Complaint
... TO INCREASE AND MAINTAIN THE PRICE OF DRUGS OUTSIDE OF THE MEDICARE PART B CONTEXT ...............................................................51 ...
... TO INCREASE AND MAINTAIN THE PRICE OF DRUGS OUTSIDE OF THE MEDICARE PART B CONTEXT ...............................................................51 ...
Administration of resveratrol: What formulation
... DMSO at ~ 16 mg.ml −1 (~70 mM) [21]. However, its hydrosolubility of ~3 mg.100 ml −1 (~ 0.13 mM) [22–24] makes it “pratically insoluble” in water according to the European Pharmacopeia definition, and its log P is 3.1 [25]. Despite this poor water solubility, resveratrol exhibits high membrane permea ...
... DMSO at ~ 16 mg.ml −1 (~70 mM) [21]. However, its hydrosolubility of ~3 mg.100 ml −1 (~ 0.13 mM) [22–24] makes it “pratically insoluble” in water according to the European Pharmacopeia definition, and its log P is 3.1 [25]. Despite this poor water solubility, resveratrol exhibits high membrane permea ...
Lamictal - GSK Source
... (1) Taking Estrogen-Containing Oral Contraceptives: In women not taking carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation [see Drug Interactions (7), Cli ...
... (1) Taking Estrogen-Containing Oral Contraceptives: In women not taking carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation [see Drug Interactions (7), Cli ...
Chestal ® Cough Monograph - Boiron USA for Health Care
... The formula for Chestal and Children’s Chestal combines several homeopathic medicines. These medicines are manufactured according to the Homeopathic Pharmacopoeia of the United States’ guidelines, using the highest standards of production and quality control. Indications for homeopathic medicines ha ...
... The formula for Chestal and Children’s Chestal combines several homeopathic medicines. These medicines are manufactured according to the Homeopathic Pharmacopoeia of the United States’ guidelines, using the highest standards of production and quality control. Indications for homeopathic medicines ha ...
Prepared By - Beckman Coulter
... wakefulness, alertness, increased energy, reduced hunger, and an overall feeling of wellbeing. The term “amphetamine” refers to a group of drugs that includes d-amphetamine, d-methamphetamine (the N-methyl derivative of amphetamine), d,l-amphetamine, methylenedioxyamphetamine (MDA), and methylenedio ...
... wakefulness, alertness, increased energy, reduced hunger, and an overall feeling of wellbeing. The term “amphetamine” refers to a group of drugs that includes d-amphetamine, d-methamphetamine (the N-methyl derivative of amphetamine), d,l-amphetamine, methylenedioxyamphetamine (MDA), and methylenedio ...
Therapeutic Monitoring of Vancomycin in Adult Patients
... adverse effects, including infusion-related toxicities, nephrotoxicity, and possible ototoxicity. Upon further investigation, it appears that the impurities in early formulations of vancomycin caused many of these adverse events.1-4 Its overall use was curtailed significantly with the development of ...
... adverse effects, including infusion-related toxicities, nephrotoxicity, and possible ototoxicity. Upon further investigation, it appears that the impurities in early formulations of vancomycin caused many of these adverse events.1-4 Its overall use was curtailed significantly with the development of ...
FAST DISSOLVING IBUPROFEN NANOCRYSTALLOADED SOLID DOSAGE FORMS Research Article
... stiffness. Ibuprofen has been used successfully for other rheumatoid diseases such as spondylitis ankylosans (Bechterew disease), juvenile rheumatoid arthritis, and acute gout seizures. However, nonsteroidal anti‐inflammatory agents only have a symptomatic effect, but the deve ...
... stiffness. Ibuprofen has been used successfully for other rheumatoid diseases such as spondylitis ankylosans (Bechterew disease), juvenile rheumatoid arthritis, and acute gout seizures. However, nonsteroidal anti‐inflammatory agents only have a symptomatic effect, but the deve ...
psychoactive substances
... The processing of drugs from plants such as the Opium poppy and Coca plant as well as the synthesis of L.S.D., Ecstasy, Amphetamines and the so-called ’designer drugs’ requires the availability of various chemicals needed in different stages of their production. Article 12 of the 1988 United Nations ...
... The processing of drugs from plants such as the Opium poppy and Coca plant as well as the synthesis of L.S.D., Ecstasy, Amphetamines and the so-called ’designer drugs’ requires the availability of various chemicals needed in different stages of their production. Article 12 of the 1988 United Nations ...
1.3.1 LEVITRA-Annotated PM dated 06-Mar-2015
... degenerative retinal disorders such as retinitis pigmentosa; its use is therefore not recommended until further information is available. Otologic Sudden decrease or loss of hearing has been reported in a few postmarketing and clinical trial cases with the use of PDE5 inhibitors, including LEVITRA. ...
... degenerative retinal disorders such as retinitis pigmentosa; its use is therefore not recommended until further information is available. Otologic Sudden decrease or loss of hearing has been reported in a few postmarketing and clinical trial cases with the use of PDE5 inhibitors, including LEVITRA. ...
Naproxen Naproxen Sodium
... For the symptomatic treatment of osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, but excluding acute gouty arthritis), the usual adult dosage of naproxen is 250–500 mg (275–550 mg of naproxen sodium) twice daily in the morning and evening. Alternatively, 250 mg of naproxen (275 mg o ...
... For the symptomatic treatment of osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, but excluding acute gouty arthritis), the usual adult dosage of naproxen is 250–500 mg (275–550 mg of naproxen sodium) twice daily in the morning and evening. Alternatively, 250 mg of naproxen (275 mg o ...
Rx Only Cyclobenzaprine Hydrochloride Extended
... A food effect study conducted in healthy adult subjects (n=15) utilizing a single dose of cyclobenzaprine hydrochloride extended-release 30 mg capsules demonstrated a statistically significant increase in bioavailability when cyclobenzaprine hydrochloride extended-release 30 mg capsules was given wi ...
... A food effect study conducted in healthy adult subjects (n=15) utilizing a single dose of cyclobenzaprine hydrochloride extended-release 30 mg capsules demonstrated a statistically significant increase in bioavailability when cyclobenzaprine hydrochloride extended-release 30 mg capsules was given wi ...
MDMA in humans: factors which affect the neuropsychobiological
... Fisk et al., 2005; Mejias et al., 2005; Milani et al., 2005; Parrott et al., 2005a, b; Quednow et al., 2004; Rizzo et al., 2005; Soar et al., 2005; Thomasius et al., 2005; Yip, et al., 2005; many others). However amongst this extensive body of empirical data, most studies have also found that some g ...
... Fisk et al., 2005; Mejias et al., 2005; Milani et al., 2005; Parrott et al., 2005a, b; Quednow et al., 2004; Rizzo et al., 2005; Soar et al., 2005; Thomasius et al., 2005; Yip, et al., 2005; many others). However amongst this extensive body of empirical data, most studies have also found that some g ...
BAX 855, a PEGylated rFVIII product with prolonged half-life
... A longer acting recombinant FVIII is expected to serve patients’ demand for a more convenient prophylactic therapy. We have developed BAX 855, a PEGylated form of Baxter’s rFVIII product ADVATETM based on the ADVATETM manufacturing process. The conjugation process for preparing BAX 855 uses a novel ...
... A longer acting recombinant FVIII is expected to serve patients’ demand for a more convenient prophylactic therapy. We have developed BAX 855, a PEGylated form of Baxter’s rFVIII product ADVATETM based on the ADVATETM manufacturing process. The conjugation process for preparing BAX 855 uses a novel ...
Download CV
... Slusher BS, Vornov JJ, Thomas AG, Hurn PD, Traystman RJ, Robinson MB, Britton P, Lu M, Tortella FC, Wozniak K, Yudkoff M, Jackson PF. “An inhibitor of NAAG hydrolysis prevents ischemic glutamate release and provides neuroprotection.” Nature Medicine, 1999, 5:1396-1402 Thomas AJ, Olkowski JH, Vornov ...
... Slusher BS, Vornov JJ, Thomas AG, Hurn PD, Traystman RJ, Robinson MB, Britton P, Lu M, Tortella FC, Wozniak K, Yudkoff M, Jackson PF. “An inhibitor of NAAG hydrolysis prevents ischemic glutamate release and provides neuroprotection.” Nature Medicine, 1999, 5:1396-1402 Thomas AJ, Olkowski JH, Vornov ...
Pharmacokinetic, solubility and dissolution profile of Anti
... USES: This medication is used to treat movement disorders caused by Parkinson's disease. It does not cure Parkinson's disease, but it may improve shakiness (tremor), muscle stiffness, loss of normal movement as your dose of other Parkinson's medication wears off (end-of-dose failure), and sudden swi ...
... USES: This medication is used to treat movement disorders caused by Parkinson's disease. It does not cure Parkinson's disease, but it may improve shakiness (tremor), muscle stiffness, loss of normal movement as your dose of other Parkinson's medication wears off (end-of-dose failure), and sudden swi ...
The use of Iboga[ine] in Equatorial African Ritual Context and the
... is evidence that iboga(ine) has long been employed in that part of Africa as a stimulant and because of its mind-changing properties. Because of its capacity to enable sustained effort by suppressing symptoms of fatigue, it was allowed, if not actively encouraged, by the German colonial authorities ...
... is evidence that iboga(ine) has long been employed in that part of Africa as a stimulant and because of its mind-changing properties. Because of its capacity to enable sustained effort by suppressing symptoms of fatigue, it was allowed, if not actively encouraged, by the German colonial authorities ...
Unveiling the compatibility of eugenol with formulation excipients by
... Assessment of chemical compatibility is inevitable for a stable and effective delivery system for any drug. Though thin layer chromatography (TLC) is considered useful, differential scanning calorimetry (DSC) is considered as one of the most suitable technique to study drug-excipient compatibility s ...
... Assessment of chemical compatibility is inevitable for a stable and effective delivery system for any drug. Though thin layer chromatography (TLC) is considered useful, differential scanning calorimetry (DSC) is considered as one of the most suitable technique to study drug-excipient compatibility s ...
Key Aspirin Information
... prescription and may be taken on a daily basis, there may be a temptation to take this drug for granted. That could be tragic. Aspirin can interact with a number of other medications. Coumadin (warfarin), for example, is a blood thinner that could cause lifethreatening hemorrhage in combination with ...
... prescription and may be taken on a daily basis, there may be a temptation to take this drug for granted. That could be tragic. Aspirin can interact with a number of other medications. Coumadin (warfarin), for example, is a blood thinner that could cause lifethreatening hemorrhage in combination with ...
Long-acting testosterone undecanoate for parenteral testosterone
... trough testosterone levels (measured immediately before the new injection) in patients receiving LA-TU remained within the physiological (eugonadal) range. This study was extended as a follow-up study for approximately 2.5 years of treatment [50]. All the patients in this study phase received TU 100 ...
... trough testosterone levels (measured immediately before the new injection) in patients receiving LA-TU remained within the physiological (eugonadal) range. This study was extended as a follow-up study for approximately 2.5 years of treatment [50]. All the patients in this study phase received TU 100 ...
Report of the National Lipid Association`s Statin Safety Task Force
... Single copy price: Regular issues $23; symposia and special issues $23. Subscription rates for individuals in field of publication for 2006 are: U.S. 1 year $121. All other countries (prices include air-speeded delivery) 1 year $292. U.S. institutions 1 year $382. All other countries (prices include ...
... Single copy price: Regular issues $23; symposia and special issues $23. Subscription rates for individuals in field of publication for 2006 are: U.S. 1 year $121. All other countries (prices include air-speeded delivery) 1 year $292. U.S. institutions 1 year $382. All other countries (prices include ...
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon ""drug"" and kinetikos ""moving, putting in motion""; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.