HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
... morphine, begin treatment using an immediate-release morphine formulation and then convert patients to KADIAN as described below. Conversion from Other Oral Morphine Formulations to KADIAN Patients receiving other oral morphine formulations may be converted to KADIAN by administering onehalf of the ...
... morphine, begin treatment using an immediate-release morphine formulation and then convert patients to KADIAN as described below. Conversion from Other Oral Morphine Formulations to KADIAN Patients receiving other oral morphine formulations may be converted to KADIAN by administering onehalf of the ...
A pharmacologic strategy for the treatment of nicotine addiction
... the mechanism underlying this attenuation is mediated in part, if not completely, through the GABAB receptor (Ashby et al., 1999). For the treatment of brain disorders such as drug addiction, Parkinson’s disease, and mental illness, the use of specific suicide inhibitors of an enzyme, like GVG, offe ...
... the mechanism underlying this attenuation is mediated in part, if not completely, through the GABAB receptor (Ashby et al., 1999). For the treatment of brain disorders such as drug addiction, Parkinson’s disease, and mental illness, the use of specific suicide inhibitors of an enzyme, like GVG, offe ...
AusPAR: Trastuzumab emtansine - Therapeutic Goods Administration
... The administrative, product usage, chemical, pharmaceutical, microbiological data submitted in support of this application have been evaluated in accordance with the Australian legislation, pharmacopoeial standards and relevant technical guidelines adopted by the TGA. The issue of free maytasinoid l ...
... The administrative, product usage, chemical, pharmaceutical, microbiological data submitted in support of this application have been evaluated in accordance with the Australian legislation, pharmacopoeial standards and relevant technical guidelines adopted by the TGA. The issue of free maytasinoid l ...
Chloramphenicol
... Intravenous chloramphenicol use has been associated with the so called gray baby syndrome. This phenomenon occurs in newborn infants because they do not yet have fully functional liver enzymes (i.e. UDP-glucuronyl transferase), and so chloramphenicol remains unmetabolized in the body This causes sev ...
... Intravenous chloramphenicol use has been associated with the so called gray baby syndrome. This phenomenon occurs in newborn infants because they do not yet have fully functional liver enzymes (i.e. UDP-glucuronyl transferase), and so chloramphenicol remains unmetabolized in the body This causes sev ...
PrCIPRO® XL
... agitation, insomnia, anxiety, paranoia, nightmares and, rarely, suicidal thoughts or acts. In some cases, depression or psychotic reactions can progress to suicidal ideations/thoughts and selfinjurious behavior, such as attempted suicide or completed suicide. These reactions may occur even following ...
... agitation, insomnia, anxiety, paranoia, nightmares and, rarely, suicidal thoughts or acts. In some cases, depression or psychotic reactions can progress to suicidal ideations/thoughts and selfinjurious behavior, such as attempted suicide or completed suicide. These reactions may occur even following ...
View/Open - East West University
... Sedative-Hypnotics are a class of drug where sedative indicates a substance that induces sedation by reducing irritability or excitement and hypnotic refers to a substance that causes drowsiness and facilitates the onset and maintenance of natural sleep. The pharmacodynamic actions of these drugs ar ...
... Sedative-Hypnotics are a class of drug where sedative indicates a substance that induces sedation by reducing irritability or excitement and hypnotic refers to a substance that causes drowsiness and facilitates the onset and maintenance of natural sleep. The pharmacodynamic actions of these drugs ar ...
Clorhidrato de Propranolol. Monografia del farmaco.
... Approximately 90% of circulating propranolol is bound to plasma proteins (albumin and alpha1 acid glycoprotein). The binding is enantiomer-selective. The S(-)-enantiomer is preferentially bound to alpha1 glycoprotein and the R(+)enantiomer preferentially bound to albumin. The volume of distribution ...
... Approximately 90% of circulating propranolol is bound to plasma proteins (albumin and alpha1 acid glycoprotein). The binding is enantiomer-selective. The S(-)-enantiomer is preferentially bound to alpha1 glycoprotein and the R(+)enantiomer preferentially bound to albumin. The volume of distribution ...
SCIENTIFIC DISCUSSION
... the recent introduction of several new AEDs has considerably increased the number of possible combinations. The rational basis for combining AEDs is largely based upon their modes of action, although these mechanisms are not fully understood for some drugs. The efficacy of the newer AEDs in adjuncti ...
... the recent introduction of several new AEDs has considerably increased the number of possible combinations. The rational basis for combining AEDs is largely based upon their modes of action, although these mechanisms are not fully understood for some drugs. The efficacy of the newer AEDs in adjuncti ...
drug registration guidance document (drgd) - NPRA
... Excipient: Substance needed for manufacturing a dosage form (used after potentisation) such as wheat starch and magnesium stearate for tablets. It may also represent the substance of the dosage form. Homeopath: A qualified provider (practitioner) of homeopathic treatment. Homeopathic medicines: Any ...
... Excipient: Substance needed for manufacturing a dosage form (used after potentisation) such as wheat starch and magnesium stearate for tablets. It may also represent the substance of the dosage form. Homeopath: A qualified provider (practitioner) of homeopathic treatment. Homeopathic medicines: Any ...
Concurrent Access to Nicotine and SucroseREVISION
... take nicotine when sucrose is concurrently available —and in many cases take it more frequently than sucrose— demonstrates that nicotine self-administration does not only occur in the absence of alternative reinforcement options. As a model of human nicotine use, concurrent access is more naturalist ...
... take nicotine when sucrose is concurrently available —and in many cases take it more frequently than sucrose— demonstrates that nicotine self-administration does not only occur in the absence of alternative reinforcement options. As a model of human nicotine use, concurrent access is more naturalist ...
These highlights do not include all the information needed to use
... trial did not experience an increase in specific clinically significant adverse events above the number expected based on the medical condition and age of the patients. 6.3 Pos tmarketing Experience The following adverse reactions have been reported during post-approval use of PERFOROMIST Inhalation ...
... trial did not experience an increase in specific clinically significant adverse events above the number expected based on the medical condition and age of the patients. 6.3 Pos tmarketing Experience The following adverse reactions have been reported during post-approval use of PERFOROMIST Inhalation ...
Dose-related sex differences in the establishment of conditioned
... Follow this and additional works at: http://ir.lib.uwo.ca/etd Part of the Experimental Analysis of Behavior Commons ...
... Follow this and additional works at: http://ir.lib.uwo.ca/etd Part of the Experimental Analysis of Behavior Commons ...
Full-Text PDF
... marker for hepatocyte necrosis, ccCK-18 (caspase-cleaved CytoKeratin-18) proposed as marker for apoptosis, hyperacetylated HMGB-1, and MCSFR-1 (Macrophage colony-stimulating factor receptor-1) proposed as marker for immune activation (Table 1) [20]. Other proposals included M-30 (apoptosis), M-65 (a ...
... marker for hepatocyte necrosis, ccCK-18 (caspase-cleaved CytoKeratin-18) proposed as marker for apoptosis, hyperacetylated HMGB-1, and MCSFR-1 (Macrophage colony-stimulating factor receptor-1) proposed as marker for immune activation (Table 1) [20]. Other proposals included M-30 (apoptosis), M-65 (a ...
Amphotericin B as a mycolic acid specific targeting agent in tuberculosis
... I would humbly like to thank the following individuals and organizations for their support towards my completion of my MSc. degree. Most importantly, our Creator and King, for the guidance and support in the good and trying times and never leaving my side. Prof. J.A. Verschoor my promoter, for his d ...
... I would humbly like to thank the following individuals and organizations for their support towards my completion of my MSc. degree. Most importantly, our Creator and King, for the guidance and support in the good and trying times and never leaving my side. Prof. J.A. Verschoor my promoter, for his d ...
Lamictal XR (lamotrigine) Extended-Release Tablets
... dose of LAMICTAL XR will in most cases need to be increased by as much as 2-fold over the recommended target maintenance dose to maintain a consistent lamotrigine plasma level. (2) Starting Estrogen-Containing Oral Contraceptives: In women taking a stable dose of LAMICTAL XR and not taking carbamaze ...
... dose of LAMICTAL XR will in most cases need to be increased by as much as 2-fold over the recommended target maintenance dose to maintain a consistent lamotrigine plasma level. (2) Starting Estrogen-Containing Oral Contraceptives: In women taking a stable dose of LAMICTAL XR and not taking carbamaze ...
MetroCream
... barrier and enters the fetal circulation rapidly. No fetotoxicity was observed after oral metronidazole in rats or mice. However, because animal reproduction studies are not always predictive of human response, this drug should only be used during pregnancy after careful assessment of the risk/benef ...
... barrier and enters the fetal circulation rapidly. No fetotoxicity was observed after oral metronidazole in rats or mice. However, because animal reproduction studies are not always predictive of human response, this drug should only be used during pregnancy after careful assessment of the risk/benef ...
Erythromycin delayed release capsules USP
... Blood levels obtained upon administration of ERYC (enteric-coated erythromycin pellets) in the presence of food are above minimum inhibitory concentrations (MIC's) of most organisms for which erythromycin is indicated. However, maximum blood levels are obtained in the fasting state (at least 30 minu ...
... Blood levels obtained upon administration of ERYC (enteric-coated erythromycin pellets) in the presence of food are above minimum inhibitory concentrations (MIC's) of most organisms for which erythromycin is indicated. However, maximum blood levels are obtained in the fasting state (at least 30 minu ...
CLINDAMYCIN Phosphate CLINDAMYCIN Hydrochloride
... 7. Septicemia and endocarditis - The effectiveness of Dalacin C in the treatment of selected cases of endocarditis has been documented when Dalacin C is determined to be bactericidal to the infecting organisms by in vitro testing of appropriate achievable serum concentrations. 8. Dental infection su ...
... 7. Septicemia and endocarditis - The effectiveness of Dalacin C in the treatment of selected cases of endocarditis has been documented when Dalacin C is determined to be bactericidal to the infecting organisms by in vitro testing of appropriate achievable serum concentrations. 8. Dental infection su ...
Salvia Divinorum
... medical studies undertaken to examine the drug's physiological effects have focused only on short-term effects. However, information provided by abusers indicates that the negative longterm effects of Salvia Divinorum may be similar to those produced by other hallucinogens such as LSD (lysergic acid ...
... medical studies undertaken to examine the drug's physiological effects have focused only on short-term effects. However, information provided by abusers indicates that the negative longterm effects of Salvia Divinorum may be similar to those produced by other hallucinogens such as LSD (lysergic acid ...
a new antiarrhythmic compound potent class iii
... activates the slow inward sodium current12. Ibutilide has been shown to be modestly effective in terminating both atrial flutter and atrial fibrillation, particularly if the arrhythmia is relatively short-lived, and may be more effective than other anti-arrhythmic drugs for this purpose13. This drug ...
... activates the slow inward sodium current12. Ibutilide has been shown to be modestly effective in terminating both atrial flutter and atrial fibrillation, particularly if the arrhythmia is relatively short-lived, and may be more effective than other anti-arrhythmic drugs for this purpose13. This drug ...
PRODUCT INFORMATION METHADONE SYRUP
... Care needs to be taken with methadone to avoid toxicity because the time to reach steadystate concentrations following a change in dosage may be up to 12 days. Dose conversion ratios from other opiods are not static, but are a function of previous opioid exposure. Incomplete cross-tolerance between ...
... Care needs to be taken with methadone to avoid toxicity because the time to reach steadystate concentrations following a change in dosage may be up to 12 days. Dose conversion ratios from other opiods are not static, but are a function of previous opioid exposure. Incomplete cross-tolerance between ...
they look for answers. Men don’t look for excuses.
... platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo. Pharmacokinetics and Metabolism VIAGRA is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41% (range 25-63%). Its pharmacokinetics are dose-proportional over the recommended dos ...
... platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo. Pharmacokinetics and Metabolism VIAGRA is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41% (range 25-63%). Its pharmacokinetics are dose-proportional over the recommended dos ...
T-61 Use in the Euthanasia of Domestic Animals: A Survey
... There were a number of comments on some of the perceived problems with T-61. Both users and non-users commented that the heart takes a long time to stop beating. Some talked of the heart continuing for as long as five minutes or more after brain death had apparently occurred. One respondent noted th ...
... There were a number of comments on some of the perceived problems with T-61. Both users and non-users commented that the heart takes a long time to stop beating. Some talked of the heart continuing for as long as five minutes or more after brain death had apparently occurred. One respondent noted th ...
Levitra - GSK Source
... LEVITRA should be used with caution by patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis, or Peyronie’s disease) or by patients who have conditions that may predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia). 5.4 Effects o ...
... LEVITRA should be used with caution by patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis, or Peyronie’s disease) or by patients who have conditions that may predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia). 5.4 Effects o ...
maxzide
... properties. It exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogen. With this action, triamterene increases sodium excretion and reduces the excessive loss of potassium and hydrogen associated with hydrochlorothiazide. Tr ...
... properties. It exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogen. With this action, triamterene increases sodium excretion and reduces the excessive loss of potassium and hydrogen associated with hydrochlorothiazide. Tr ...
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon ""drug"" and kinetikos ""moving, putting in motion""; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.