Nerve Cells
... • The nodes are the only regions along the axon where the axonal membrane is in direct contact with the extracellular fluid ...
... • The nodes are the only regions along the axon where the axonal membrane is in direct contact with the extracellular fluid ...
Missy Cavallin September 14, 2007
... Assigned Experimental Papers (structure, voltage sensor, inactivation) ...
... Assigned Experimental Papers (structure, voltage sensor, inactivation) ...
Functional Imaging Graduate Class
... multiple, spatially separated entities (molecules/cells/brain regions); whereas classical techniques (patch-clamp/microelectrode recording) monitor only one at a time. e.g. nominally identical nAChR channels (expressed from the same cloned gene) display widely varying properties ...
... multiple, spatially separated entities (molecules/cells/brain regions); whereas classical techniques (patch-clamp/microelectrode recording) monitor only one at a time. e.g. nominally identical nAChR channels (expressed from the same cloned gene) display widely varying properties ...
Lecture 1, Chapter 1 Overview: History and the neuron
... What is the nature of these chemicals? Hodgkin and Katz (1949) Working with giant squids can lead to problems “The values for spike height are in good agreement with those obtained by Hodgkin and Huxley (1945), but are considerably smaller than those reported by Curtis and Cole (1942). The average v ...
... What is the nature of these chemicals? Hodgkin and Katz (1949) Working with giant squids can lead to problems “The values for spike height are in good agreement with those obtained by Hodgkin and Huxley (1945), but are considerably smaller than those reported by Curtis and Cole (1942). The average v ...
Regulation of ion channels
... • voltage-gated Na+ channel is bell-shaped by electron microscopy • opening of channel coincides with measured displacement of charged amino acids (gating charge) – movement of positively charged S4 helices • mutation of inactivating sequence or its binding site abolishes refractory period ...
... • voltage-gated Na+ channel is bell-shaped by electron microscopy • opening of channel coincides with measured displacement of charged amino acids (gating charge) – movement of positively charged S4 helices • mutation of inactivating sequence or its binding site abolishes refractory period ...
Membrane transport
... The schematic is for a drug exporter. The drug-binding site (red) is high-affinity and faces the inner leaflet of the membrane. Step I: the transport cycle is initiated by binding of substrate to its high-affinity site on the TMDs from the inner leaflet of the membrane. The affinity of the NBDs for ...
... The schematic is for a drug exporter. The drug-binding site (red) is high-affinity and faces the inner leaflet of the membrane. Step I: the transport cycle is initiated by binding of substrate to its high-affinity site on the TMDs from the inner leaflet of the membrane. The affinity of the NBDs for ...
Protein Folding and Membrane Structure
... • Singer and Nicolson (1972) synthesized a variety of results that implied the unit membrane is a fluid and contains proteins as integral components • Today we recognize fluidity restrictions and local membrane domains (Domain Mosaic Model) ...
... • Singer and Nicolson (1972) synthesized a variety of results that implied the unit membrane is a fluid and contains proteins as integral components • Today we recognize fluidity restrictions and local membrane domains (Domain Mosaic Model) ...
Topic 8 Checkpoint Answers File
... The inside of the rod cell becomes more negative. The rod cell becomes hyperpolarised. Release of neurotransmitter stops. Neurotransmitter no longer inhibits cation channels in bipolar cells. Cation channels in bipolar cells open. The bipolar cell depolarises and produces an action potential. The im ...
... The inside of the rod cell becomes more negative. The rod cell becomes hyperpolarised. Release of neurotransmitter stops. Neurotransmitter no longer inhibits cation channels in bipolar cells. Cation channels in bipolar cells open. The bipolar cell depolarises and produces an action potential. The im ...
S U M M A R Y
... extracellular pH to 6.2. These characteristics indicate that TASK channels are likely present in OVCAR3 cells. Besides TASK, other K+ conducting channels must be present in OVCAR3 cells as well, as TASK channels are not known to have the large voltage gated single channel openings with a slope condu ...
... extracellular pH to 6.2. These characteristics indicate that TASK channels are likely present in OVCAR3 cells. Besides TASK, other K+ conducting channels must be present in OVCAR3 cells as well, as TASK channels are not known to have the large voltage gated single channel openings with a slope condu ...
Active transport
... consensus structure based on structures of several NBDs and modeled for P-gp17 is shown. The two ATP molecules and two magnesium ions, shown in ball-and-stick and colored by atom types, occupy the two nucleotide-binding pockets at the interface between the two NBDs and are coordinated by residues fr ...
... consensus structure based on structures of several NBDs and modeled for P-gp17 is shown. The two ATP molecules and two magnesium ions, shown in ball-and-stick and colored by atom types, occupy the two nucleotide-binding pockets at the interface between the two NBDs and are coordinated by residues fr ...
Test questions used for assessment
... 6. Which of the following are true? a. microtubules are important in the transport of vesicles and the movement of cilia and flagella b. microfilaments are important in cellular contractile systems and mechanical support c. the microtrabecular lattice suspends other cytoskeletal parts, organelles, a ...
... 6. Which of the following are true? a. microtubules are important in the transport of vesicles and the movement of cilia and flagella b. microfilaments are important in cellular contractile systems and mechanical support c. the microtrabecular lattice suspends other cytoskeletal parts, organelles, a ...
Maxi Potassium channel beta peptide ab5023 Product datasheet 1 References Overview
... General Info Relevance ...
... General Info Relevance ...
Active and Passive Transport
... Movement of molecules against the concentration gradient, with expenditure of energy. The process involves membrane proteins. Active Transport includes: Sodium Potassium Pump Proton Pump Passive Transport Diffusion- the movement of molecules, from a region of high concentration to a region of low co ...
... Movement of molecules against the concentration gradient, with expenditure of energy. The process involves membrane proteins. Active Transport includes: Sodium Potassium Pump Proton Pump Passive Transport Diffusion- the movement of molecules, from a region of high concentration to a region of low co ...
Polarised membrane A membrane with a potential difference across
... Channels in the cell membrane that allow the passage of charged particles or ions. They have a mechanism called a gate which can open and close the channel. In these channels the gates respond to changes in the potential difference across the membrane. ...
... Channels in the cell membrane that allow the passage of charged particles or ions. They have a mechanism called a gate which can open and close the channel. In these channels the gates respond to changes in the potential difference across the membrane. ...
Biomedical applications
... Molecular self-assembly and bio-interfaces Bio-electronics (sensors) and bio-chips Drug delivery system (DDS) Synthesis, engineer and manipulate bio-materials Basic units: Lipid, protein, and DNA Other bio-compatible materials ...
... Molecular self-assembly and bio-interfaces Bio-electronics (sensors) and bio-chips Drug delivery system (DDS) Synthesis, engineer and manipulate bio-materials Basic units: Lipid, protein, and DNA Other bio-compatible materials ...
Fig. 4.3 - glenbrook s hs
... • Semi-permeable (selectively permeable) – allows some substances to pass through, but blocks the passgae of other substances • Membranes enclose and maintain the specific chemical environment • Every membrane carries out its specific functions ...
... • Semi-permeable (selectively permeable) – allows some substances to pass through, but blocks the passgae of other substances • Membranes enclose and maintain the specific chemical environment • Every membrane carries out its specific functions ...
Chapter 5 Section 1: Passive Transport
... 17. When water diffuses into a plant cell and builds up firm pressure, that is called _____________ _________________. (pg. 100) 18. When water diffuses out of a plant cell and causes the cell membrane to shrink, that is called _________________________. 19. Define facilitated diffusion: 20. In faci ...
... 17. When water diffuses into a plant cell and builds up firm pressure, that is called _____________ _________________. (pg. 100) 18. When water diffuses out of a plant cell and causes the cell membrane to shrink, that is called _________________________. 19. Define facilitated diffusion: 20. In faci ...
Slide ()
... numbers of channels at the cell surface, owing to a prolonged half-life of channels at the cell surface. Dominant-negative dynamin mutations result in phenocopies of Liddle syndrome, as do dominant-negative mutations of Nedd-4. Given the known role of dynamin in endocytosis via clathrin-coated pits ...
... numbers of channels at the cell surface, owing to a prolonged half-life of channels at the cell surface. Dominant-negative dynamin mutations result in phenocopies of Liddle syndrome, as do dominant-negative mutations of Nedd-4. Given the known role of dynamin in endocytosis via clathrin-coated pits ...
What should I know for the test with blanks
... DIFFUSIONFACILITATED DIFFUSION with CARRIERS - Glucose FACILITATED DIFFUSION with AQUAPORINS (OSMOSIS)FACILITATED DIFFUSION with ION CHANNELS - Ca++, Na+, K+, ClNa+-K+ PUMPPROTON PUMPENDOCYTOSIS (PHAGOCYTOSIS) ENDOCYTOSIS (PINOCYTOSIS)EXOCYTOSIS Which kind of transport do white blood cells use when ...
... DIFFUSIONFACILITATED DIFFUSION with CARRIERS - Glucose FACILITATED DIFFUSION with AQUAPORINS (OSMOSIS)FACILITATED DIFFUSION with ION CHANNELS - Ca++, Na+, K+, ClNa+-K+ PUMPPROTON PUMPENDOCYTOSIS (PHAGOCYTOSIS) ENDOCYTOSIS (PINOCYTOSIS)EXOCYTOSIS Which kind of transport do white blood cells use when ...
Exam 1 suggested answers (2010)
... 4.a. Expose the developing organism to an altered DNA nucleotide such as tritiated thymidine or bromodeoxyuridine at different developmental stages. Later locate cells containing the altered nucleotide; these cells must have been still dividing at the time of exposure to label; unlabelled cells must ...
... 4.a. Expose the developing organism to an altered DNA nucleotide such as tritiated thymidine or bromodeoxyuridine at different developmental stages. Later locate cells containing the altered nucleotide; these cells must have been still dividing at the time of exposure to label; unlabelled cells must ...
P215 - Basic Human Physiology
... • Depolarization caused by increased permeability to ions • Permeability typically increased by chemically-or physically-gated ion channels • Can also be affected by membrane perturbations, changes in ion gradients, etc. ...
... • Depolarization caused by increased permeability to ions • Permeability typically increased by chemically-or physically-gated ion channels • Can also be affected by membrane perturbations, changes in ion gradients, etc. ...
Mechanosensitive channels
Mechanosensitive channels or mechanosensitive ion channels are membrane proteins capable of responding to mechanical stress over a wide dynamic range of external mechanical stimuli. They are found in prokaryotes and eukaryotes. The channels vary in selectivity for the permeating ions from nonselective between anions and cations in bacteria, to cation selective allowing passage Ca2+, K+ and Na+ in eukaryotes, and highly selective K+ channels in bacteria and eukaryotes.All organisms, and apparently all cell types, sense and respond to mechanical stimuli. MSCs function as mechanotransducers capable of generating both electrical and ion flux signals as a response to external or internal stimuli. Under extreme turgor in bacteria, non selective MSCs such as MSCL and MSCS serve as safety valves to prevent lysis. In specialized cells of the higher organisms, other types of MSCs are probably the basis of the senses of hearing and touch and sense the stress needed for muscular coordination. However, none of these channels have been cloned. MSCs also allow plants to distinguish up from down by sensing the force of gravity. MSCs are not pressure-sensitive, but sensitive to local stress, most likely tension in the surrounding lipid bilayer.