Focus Article
... or wounding, generates a complex stress response that extends beyond the nervous system and contributes to the experience of pain. Through a common chemical language comprising neurotransmitters, peptides, endocannabinoids, cytokines, and hormones, an ensemble of interdependent nervous, endocrine, a ...
... or wounding, generates a complex stress response that extends beyond the nervous system and contributes to the experience of pain. Through a common chemical language comprising neurotransmitters, peptides, endocannabinoids, cytokines, and hormones, an ensemble of interdependent nervous, endocrine, a ...
Penetration of Stratified Mucosa Cytolysins Augment Superantigen
... of TSST-1 to penetrate the mucosa. Ex vivo porcine tissue is an excellent model of human vaginal tissue; vaginal tissue from both human and pig is a nonkeratinized stratified squamous epithelium with intercellular lipids, including ceramides, glucosyl ceramides, and cholesterol located in the surfac ...
... of TSST-1 to penetrate the mucosa. Ex vivo porcine tissue is an excellent model of human vaginal tissue; vaginal tissue from both human and pig is a nonkeratinized stratified squamous epithelium with intercellular lipids, including ceramides, glucosyl ceramides, and cholesterol located in the surfac ...
Inflammatory Monocytes Activate Memory CD8+ T and
... either in nonimmunized or immunized hosts documented that, similarly to natural killer (NK) cells (Chaix et al., 2008; Lucas et al., 2007; Nguyen et al., 2002), memory CD8+ T cells can respond to distinct inflammatory cytokines (Berg et al., 2003; Kambayashi et al., 2003; Kohlmeier et al., 2010; Liu ...
... either in nonimmunized or immunized hosts documented that, similarly to natural killer (NK) cells (Chaix et al., 2008; Lucas et al., 2007; Nguyen et al., 2002), memory CD8+ T cells can respond to distinct inflammatory cytokines (Berg et al., 2003; Kambayashi et al., 2003; Kohlmeier et al., 2010; Liu ...
Adhesion Proteins PCOL 582
... Depending on the association of alpha and beta subunits, integrins can bind to collagen, laminin, vitronectin, and fibronectin. ...
... Depending on the association of alpha and beta subunits, integrins can bind to collagen, laminin, vitronectin, and fibronectin. ...
TIR-Domain-Containing Adapter-Inducing Interferon
... signaling through either MyD88 (myeloid differentiation factor 88) or TRIF (Toll/interleukin-1 receptor domain-containing adapter inducing IFN-β) to initiate innate immune responses to pathogens and activate antigen-presenting cells. Mucosal B cells can be directly activated by antigens and TLR sign ...
... signaling through either MyD88 (myeloid differentiation factor 88) or TRIF (Toll/interleukin-1 receptor domain-containing adapter inducing IFN-β) to initiate innate immune responses to pathogens and activate antigen-presenting cells. Mucosal B cells can be directly activated by antigens and TLR sign ...
The presence of cytotoxic autoantibody to lacrimal gland cells
... spontaneously and develop diseases which mimic systemic lupus erythematosus and Sjogren's syndrome in humans.4-5'8'9 The predominant immunologic feature of NZB/W mice is the presence of hyperactive B-cells early in life. This results in the abundant production of various autoantibodies such as antin ...
... spontaneously and develop diseases which mimic systemic lupus erythematosus and Sjogren's syndrome in humans.4-5'8'9 The predominant immunologic feature of NZB/W mice is the presence of hyperactive B-cells early in life. This results in the abundant production of various autoantibodies such as antin ...
Naive B cells generate regulatory T cells in the
... served as negative controls. The immunoregulatory effect of adoptively transferred primed T cells was tested by intravenously transferring 0.5 to 5 ⫻ 106 MACS-separated DC–primed or B-cell–primed T cells at day 1 (for inhibition of priming) or at day 4 (for inhibition of challenge), or at d 10 (for ...
... served as negative controls. The immunoregulatory effect of adoptively transferred primed T cells was tested by intravenously transferring 0.5 to 5 ⫻ 106 MACS-separated DC–primed or B-cell–primed T cells at day 1 (for inhibition of priming) or at day 4 (for inhibition of challenge), or at d 10 (for ...
Thymus-Therapie in Practice
... The immune system is made up of a network of cellular and humoral systems to combat micro-organisms, parasites and viruses. The ability to do this is particularly important in the removal of cells that have degenerated within the body and become “foreign”. The first cancer cells to develop should be ...
... The immune system is made up of a network of cellular and humoral systems to combat micro-organisms, parasites and viruses. The ability to do this is particularly important in the removal of cells that have degenerated within the body and become “foreign”. The first cancer cells to develop should be ...
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T
... and proportions of T and B lymphocytes in both the naïve and memory compartments. T and B cell populations are independently regulated1 and the size of the naïve and memory T cell pools appear to be independently maintained2. Under normal circumstances, T cell homeostasis is probably mediated by mai ...
... and proportions of T and B lymphocytes in both the naïve and memory compartments. T and B cell populations are independently regulated1 and the size of the naïve and memory T cell pools appear to be independently maintained2. Under normal circumstances, T cell homeostasis is probably mediated by mai ...
- Journal of Allergy and Clinical Immunology
... hygiene hypothesis is the skewing of the TH1/TH2 balance away from allergy-promoting TH2 cells toward TH1 cells.1 The link between the TH1/TH2 balance and allergic diseases is mediated in part by IgE: TH2 cells, by secreting IL-4 and IL-13, promote immunoglobulin class-switch recombination to IgE (f ...
... hygiene hypothesis is the skewing of the TH1/TH2 balance away from allergy-promoting TH2 cells toward TH1 cells.1 The link between the TH1/TH2 balance and allergic diseases is mediated in part by IgE: TH2 cells, by secreting IL-4 and IL-13, promote immunoglobulin class-switch recombination to IgE (f ...
IMMUNOLOGY LEARNING OBJECTIVES
... Peptides produced as part of normal cell metabolism then degraded by proteosomes meanwhile: alpha an dbeta-2 class I chains synth with leader sequences that direct their translocation to ER where calnexin (ER transmembrane prot) physically associates with alpha chain and facilitates its dimeri ...
... Peptides produced as part of normal cell metabolism then degraded by proteosomes meanwhile: alpha an dbeta-2 class I chains synth with leader sequences that direct their translocation to ER where calnexin (ER transmembrane prot) physically associates with alpha chain and facilitates its dimeri ...
NIH Public Access - IUPUI ScholarWorks
... the innate and adaptive immune systems. Similar to viral PAMPs and cellular DAMPs, components of the complement pathway in the lung provide additional immunological cues to DC activation and antiviral immunity to IAV infection. Complements, however, affect DC migration rather than the DC’s T cell st ...
... the innate and adaptive immune systems. Similar to viral PAMPs and cellular DAMPs, components of the complement pathway in the lung provide additional immunological cues to DC activation and antiviral immunity to IAV infection. Complements, however, affect DC migration rather than the DC’s T cell st ...
Effects of intracellular and extracellular heat shock proteins on anti
... The adaptive immune system is a highly sophisticated and potent system and needs to be instructed and regulated by antigen-presenting cells (APCs). Dendritic cells (DC) are unique APCs because they are the only ones that are able to induce primary immune responses, thus permitting the establishment ...
... The adaptive immune system is a highly sophisticated and potent system and needs to be instructed and regulated by antigen-presenting cells (APCs). Dendritic cells (DC) are unique APCs because they are the only ones that are able to induce primary immune responses, thus permitting the establishment ...
Full Reviews Immunity in arterial hypertension
... As the most data are available on the action of TLR4 on hypertensive target organ damage and hypertension, the focus here is set primarily on TLR4 (Figure 1). The best-known source of TLR4 ligand is lipopolysaccharide (LPS) derived from Gram-negative bacteria. Other TLR4 ligands, such as HMGB-1 and ...
... As the most data are available on the action of TLR4 on hypertensive target organ damage and hypertension, the focus here is set primarily on TLR4 (Figure 1). The best-known source of TLR4 ligand is lipopolysaccharide (LPS) derived from Gram-negative bacteria. Other TLR4 ligands, such as HMGB-1 and ...
webinar 3
... bowel and immune health of infants between 1 month and 3 years old. • Suitable for babies suffering from colic type symptoms and immune based atopic conditions such as eczema. ...
... bowel and immune health of infants between 1 month and 3 years old. • Suitable for babies suffering from colic type symptoms and immune based atopic conditions such as eczema. ...
Document
... Elements of Adaptive Immunity • B Lymphocytes (B Cells) and Antibodies – Specificity of the B cell receptor (BCR) – Each B lymphocyte has multiple copies of a single type of protein called the B cell receptor – Each B cell generates a single BCR – The two variable regions of the BCR form the antige ...
... Elements of Adaptive Immunity • B Lymphocytes (B Cells) and Antibodies – Specificity of the B cell receptor (BCR) – Each B lymphocyte has multiple copies of a single type of protein called the B cell receptor – Each B cell generates a single BCR – The two variable regions of the BCR form the antige ...
The effects of HIV Tat DNA on regulating the Open Access
... and encodes a 72-amino acid peptide which mediates the virus trans-activation [15]. The C-terminal amino acids which are encoded by the second Tat exon contain the arginine-glycine-aspartic acid (RGD) motif and mediate cell adhesion and binding of extracellular Tat [16]. In most cases, HIV-1 Tat is ...
... and encodes a 72-amino acid peptide which mediates the virus trans-activation [15]. The C-terminal amino acids which are encoded by the second Tat exon contain the arginine-glycine-aspartic acid (RGD) motif and mediate cell adhesion and binding of extracellular Tat [16]. In most cases, HIV-1 Tat is ...
Sepsis
... Two types of sepsis Early-onset sepsis, with in the first 72 hours of life Late-onset sepsis, those infections acquired later by horizontal transmission. Highest risk for the first month of life ...
... Two types of sepsis Early-onset sepsis, with in the first 72 hours of life Late-onset sepsis, those infections acquired later by horizontal transmission. Highest risk for the first month of life ...
THE INTERLEUKIN-1β-MEDIATED REGULATION OF
... Abstract––Opioids have been found to modulate the function of the immune system by regulating the biochemical and proliferative properties of its cellular components. The interaction of opioid and immune systems, however, is not unidirectional, but rather, bidirectional in nature. In the CNS, one ce ...
... Abstract––Opioids have been found to modulate the function of the immune system by regulating the biochemical and proliferative properties of its cellular components. The interaction of opioid and immune systems, however, is not unidirectional, but rather, bidirectional in nature. In the CNS, one ce ...
Long-Term Protective Immunity Induced Against
... and T cell responses. Immunizations of mice with rAdASP2 and rAdTS induced high levels of serum antibodies specific for their recombinant products. In addition, both recombinant viruses were able to elicit a biased helper T cell type 1 (Th1) cellular immune response and a substantial CD8 T cell-med ...
... and T cell responses. Immunizations of mice with rAdASP2 and rAdTS induced high levels of serum antibodies specific for their recombinant products. In addition, both recombinant viruses were able to elicit a biased helper T cell type 1 (Th1) cellular immune response and a substantial CD8 T cell-med ...
Immune system
The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.