ABSTRACT - Johns Hopkins University
... Several studies have demonstrated a critical role for stromal elements in the development of cancer. Interactions between mesenchymal cells and epithelial cells through direct cell-to-cell contact and soluble factors are necessary for maintenance of regulated cell growth and tissue architecture. Per ...
... Several studies have demonstrated a critical role for stromal elements in the development of cancer. Interactions between mesenchymal cells and epithelial cells through direct cell-to-cell contact and soluble factors are necessary for maintenance of regulated cell growth and tissue architecture. Per ...
... stable disulphide bonds. Reduced glutathione, a tripeptide consisting of cysteine, glutamic acid and glycine, is a low molecular weight thiol. In addition to its antioxidant properties, it can conjugate xenobiotics to aid their elimination [4–6]. Reduced glutathione reacts to form glutathione disulp ...
How Mycobacterium tuberculosis Manipulates Innate and Adaptive Immunity: New Views of
... receptors on the host cell surface, including the mannose receptor and the complement receptor (Le Cabec, Carreno et al. 2002; Kang, Azad et al. 2005) and during prolonged infection of cell cultures, the glycolipid is trafficked throughout the membrane compartments of the host cell (Xu, Cooper et al ...
... receptors on the host cell surface, including the mannose receptor and the complement receptor (Le Cabec, Carreno et al. 2002; Kang, Azad et al. 2005) and during prolonged infection of cell cultures, the glycolipid is trafficked throughout the membrane compartments of the host cell (Xu, Cooper et al ...
Epithelial antimicrobial peptides and proteins: their role in
... and propagation of a specific immune response. Inflammatory cells may cause tissue injury. Chemoattractants such as chemokines play a central role in the regulation of cell recruitment. Recent data suggest that not only chemokines and other chemoattractants but also α-defensins, β-defensins and LL-3 ...
... and propagation of a specific immune response. Inflammatory cells may cause tissue injury. Chemoattractants such as chemokines play a central role in the regulation of cell recruitment. Recent data suggest that not only chemokines and other chemoattractants but also α-defensins, β-defensins and LL-3 ...
Proteomics Analysis of Immunoprecipitated Proteins Associated with
... be largely responsible for the difference in activity. A putative PEST sequence was also found between residues 415 and 438. In this study, we attempted to determine potential binding partners to Cot and their region of association by separating proteins that were pulled-down with various Cot constr ...
... be largely responsible for the difference in activity. A putative PEST sequence was also found between residues 415 and 438. In this study, we attempted to determine potential binding partners to Cot and their region of association by separating proteins that were pulled-down with various Cot constr ...
Biological Activities of Complement
... proposed (Scheme 3). Recent reviews including information on this system are those by Fearon & Austen (1976) and Fothergill &Anderson (1978). This pathway is activated by certain immunoglobulins, such as immunoglobulin A, that do not activate the classical pathway, and by various polysaccharides, su ...
... proposed (Scheme 3). Recent reviews including information on this system are those by Fearon & Austen (1976) and Fothergill &Anderson (1978). This pathway is activated by certain immunoglobulins, such as immunoglobulin A, that do not activate the classical pathway, and by various polysaccharides, su ...
Instructions for Handling PDF Galley Proofs
... of infected cells in vivo—in which CD4+ Tcms are relatively spared, whereas CD4+ effector memory T cells (Tems) are the main viral targets (30)—has led to a model of AIDS pathogenesis that proposes that the subset of cells infected is more important than the total number of infected cells or the lev ...
... of infected cells in vivo—in which CD4+ Tcms are relatively spared, whereas CD4+ effector memory T cells (Tems) are the main viral targets (30)—has led to a model of AIDS pathogenesis that proposes that the subset of cells infected is more important than the total number of infected cells or the lev ...
Viral Vaccines - Molecular Immunology
... • Infects human cells but some do not replicate • Better presentation of antigen • Generate T cell response Minuses •Can cause bad reactions •Can be problems with pre-exisiting immunity to virus •Often can only accommodate one or two antigens ...
... • Infects human cells but some do not replicate • Better presentation of antigen • Generate T cell response Minuses •Can cause bad reactions •Can be problems with pre-exisiting immunity to virus •Often can only accommodate one or two antigens ...
determining the innate and adaptive immune responses to vesicular
... According to the Centers for Disease Control and Prevention there are vaccines targeting 27 different infectious diseases approved for use in the United States; 17 viral and 10 bacterial (11). Several vaccines have performed exceptionally and have reduced cases of the disease in the U.S. to zero; sm ...
... According to the Centers for Disease Control and Prevention there are vaccines targeting 27 different infectious diseases approved for use in the United States; 17 viral and 10 bacterial (11). Several vaccines have performed exceptionally and have reduced cases of the disease in the U.S. to zero; sm ...
Function The Structure of Avian CD5 Implies a Conserved
... In addition to the ORF, CD5 cDNA clone contained an 18nucleotide (nt) 59 untranslated region and a 513-nt long 39 untranslated region including a polyadenylation signal (AATAAA) 15 nt prior to the poly(A) tail. Analysis of the CD5 amino acid sequence The ORF in p2.191 encodes a 474 amino acid protei ...
... In addition to the ORF, CD5 cDNA clone contained an 18nucleotide (nt) 59 untranslated region and a 513-nt long 39 untranslated region including a polyadenylation signal (AATAAA) 15 nt prior to the poly(A) tail. Analysis of the CD5 amino acid sequence The ORF in p2.191 encodes a 474 amino acid protei ...
Mucus Properties and Goblet Cell Quantification in Mouse, Rat and
... them to the immune cells in the subepithelial dome of the patch [11,15,16]. Uptake and transport of antigen and bacteria over the FAE is increased compared to regular villus epithelium, which results in higher amounts of transported material reaching the subepithelial dome [16]. Transepithelial tran ...
... them to the immune cells in the subepithelial dome of the patch [11,15,16]. Uptake and transport of antigen and bacteria over the FAE is increased compared to regular villus epithelium, which results in higher amounts of transported material reaching the subepithelial dome [16]. Transepithelial tran ...
Single-cell analysis of the dynamics and functional outcomes of
... contacted by an NK cell.30 Analyses in microwells have also shown that individual primary human NK cells undergo dynamic changes in their migratory behavior by transitioning between directed migration, random migration, and periods of transient arrests in migration.32 Microscopy-based assays using m ...
... contacted by an NK cell.30 Analyses in microwells have also shown that individual primary human NK cells undergo dynamic changes in their migratory behavior by transitioning between directed migration, random migration, and periods of transient arrests in migration.32 Microscopy-based assays using m ...
FVIII Immunity: Early Events and Tolerance Mechanisms to FVIII
... C57BL/6 and Balb/c mice after 4 FVIII treatments………………..37 Figure 2.3 Detection of Th1 and Th2 cytokines release by splenocyte isolated from C57BL/6 and Balb/c after 120 hrs of culture with 1ug/mL of FVIII……………………………………………………………………..39 Figure 2.4 Detection of intracellular Th1 and Th2 cytokines prod ...
... C57BL/6 and Balb/c mice after 4 FVIII treatments………………..37 Figure 2.3 Detection of Th1 and Th2 cytokines release by splenocyte isolated from C57BL/6 and Balb/c after 120 hrs of culture with 1ug/mL of FVIII……………………………………………………………………..39 Figure 2.4 Detection of intracellular Th1 and Th2 cytokines prod ...
Artificial Immune Systems
... mechanisms exist to allow the immune system to remember the pathogen. This enables a faster and more effective secondary response that can be elicited against the pathogen if it is encountered again. The adaptive and innate arms of the immune system interact to provide the body with a comprehensive ...
... mechanisms exist to allow the immune system to remember the pathogen. This enables a faster and more effective secondary response that can be elicited against the pathogen if it is encountered again. The adaptive and innate arms of the immune system interact to provide the body with a comprehensive ...
Chemical basis of ABO subgroups
... ABO genetics The ABO gene is located at the long arm of chromosome 9q34 [14] and consists of seven exons and introns, covering approximately 20 kilobase pairs from the initiation to the stop codons. The nucleotide sequence of the A allele cDNA consists of 1062 base pairs, and encodes the enzyme prot ...
... ABO genetics The ABO gene is located at the long arm of chromosome 9q34 [14] and consists of seven exons and introns, covering approximately 20 kilobase pairs from the initiation to the stop codons. The nucleotide sequence of the A allele cDNA consists of 1062 base pairs, and encodes the enzyme prot ...
34130-Review
... immunoregulatory response, inducing apoptosis by cell-cell contact in CD43+ pro/pre-B cells. This cell death signal is regulated mainly via a specific soluble stromal cell-dependent death signal that is presumably regulated by its responsive AhR gene, CYP1A1[10,30,39,40]. Later, the authors of the ...
... immunoregulatory response, inducing apoptosis by cell-cell contact in CD43+ pro/pre-B cells. This cell death signal is regulated mainly via a specific soluble stromal cell-dependent death signal that is presumably regulated by its responsive AhR gene, CYP1A1[10,30,39,40]. Later, the authors of the ...
Hypersensitivity
... By derivation, what does allergy mean and what does hypersensitivity mean? Are they synonymous? The main difference between immediate and delayed types of hypersensivitiy is the time of appearance of the reactions. True/False? If false, name the main differences. What is the type II reaction de ...
... By derivation, what does allergy mean and what does hypersensitivity mean? Are they synonymous? The main difference between immediate and delayed types of hypersensivitiy is the time of appearance of the reactions. True/False? If false, name the main differences. What is the type II reaction de ...
INTERPLAY BETWEEN HELICOBACTER PYLORI AND THE
... neutrophils and monocytes to activate their inflammatory function (24). NAP activates both neutrophils and monocytes to produce reactive oxygen species (ROS) by activating the plasma membrane NADPH. On the other hand, H. pylori to neutralize negative effects of ROS produces enzymes e.g. catalase and ...
... neutrophils and monocytes to activate their inflammatory function (24). NAP activates both neutrophils and monocytes to produce reactive oxygen species (ROS) by activating the plasma membrane NADPH. On the other hand, H. pylori to neutralize negative effects of ROS produces enzymes e.g. catalase and ...
Nuclear Melatonin Receptors
... Key words: melatonin, orphan nuclear receptors, ROR/RZR, RORE hormone response elements, differentiation, regula tion, immune system, nervous system, lipid metabolism ...
... Key words: melatonin, orphan nuclear receptors, ROR/RZR, RORE hormone response elements, differentiation, regula tion, immune system, nervous system, lipid metabolism ...
Regulation of Granulocyte-Macrophage Colony
... included as DNA competitors, but only partially inhibited when an unrelated competitor (X) was used. NFATp appeared to be the major protein contributing to NFATpk-like complexes with the GM430 probe in C 11STH and HUVE extracts as antibodies raised against either recombinant NFATp or toan NFATp pept ...
... included as DNA competitors, but only partially inhibited when an unrelated competitor (X) was used. NFATp appeared to be the major protein contributing to NFATpk-like complexes with the GM430 probe in C 11STH and HUVE extracts as antibodies raised against either recombinant NFATp or toan NFATp pept ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.