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helper T cells
helper T cells

... As depicted in Figure 57–3, B cells can perform two important functions during the induction process: (1) they recognize antigens with their surface IgM that acts as an antigen receptor (2) they present epitopes to helper T cells in association with class II MHC proteins. Note that the IgM antigen r ...
Document
Document

... Provides protection against disruption by pathogens or toxins Helps discriminate between “self” and “nonself” Pathogen - Definition: – Any disease causing agent (microorganisms) ...
Immune System
Immune System

... pathogens, or the toxins of these pathogens, by vaccination or injection of antibodies. ...
Immunity L.Saba Abood
Immunity L.Saba Abood

... is composed of a number of blood plasma proteins. which can bind to mast cells and trigger the histamine release other can attract phagocytes to the scene. Interferons are proteins produced by virus-infected cells as a warning to noninfected cells in the area. Interferon binds to receptors on non-in ...
40 -2 THE IMMUNE SYSTEM
40 -2 THE IMMUNE SYSTEM

... Fever – Raises body temperature & heart rate to destroy pathogens and increase WBC rate of response. Specific Defense 3. Immune Response – A series of specific defenses designed to attack a particular pathogen. Antigen – A foreign protein ID) that triggers an immune response. Lymphocytes – WBCs in b ...
Immune System Basics
Immune System Basics

... foreign antigen stuck in it) with its CD4 receptor.  Helper T cells have incredible variety of receptors that act like a “lock and key” in regards to the displayed antigen.  If the Helper T’s “key” fits the displayed antigen’s “lock”, the Helper T is activated.  Activation results in Helper T rel ...
An immune system is a collection of mechanisms within an organism
An immune system is a collection of mechanisms within an organism

... Passive memory Passive immunity is usually short-term, lasting between a few days and several months. Newborn infants have no prior exposure to microbes and are particularly vulnerable to infection. Several layers of passive protection are provided by the mother. During pregnancy, a particular type ...
Immune System Disorders
Immune System Disorders

... Occasionally the reactions of the immune system are harmful: Instead of producing a desirable result, such as immunity to disease, the immune system may over-react, react to the wrong substances, or not react when it should. The immune system may fail to detect an infectious agent that has penetrate ...
Immunology
Immunology

... • immune responsiveness maps to the MHC • MHC haplotye is inherited MHC alleles ...
2. seminar 2012
2. seminar 2012

... Simultaneous activation of BCR and other receptors on B cells (i.e. LPS binding protein /CD14) induces the B cells to proliferate and differentiate (extra activation signal) ...
types and functions of lymphocytes. learning objective
types and functions of lymphocytes. learning objective

...  This usually happens in a lymphoid organ, bloodstream, or lymph vessel.  (This could take quite some time…) ...
Cell Communication
Cell Communication

... • Play a key role in cell-cell recognition – ability of a cell to distinguish one cell from another • antigens – important in organ & tissue development – basis for rejection of foreign cells by immune system ...
Forensic Biology by Richard Li
Forensic Biology by Richard Li

... binding to the subsequently produced antibodies. Antigens are generally proteins or polysaccharides, but other substances such as nucleic acids can also be antigens. ...
Immune System - World of Teaching
Immune System - World of Teaching

... Section 6- Immune System ...
31.2 Immune System
31.2 Immune System

... • White blood cells attack infections inside the body. – Phagocytes: Cell that engulfs and destroys pathogens. – T cells: Destroys infected body cells. – B cells: Produces antibodies. ...
Computational Immunology An Introduction
Computational Immunology An Introduction

... Self-Reactive Protein • Multiple Sclerosis (MS) is caused by the destruction of the Myelin sheets which surround nerve cells • T cells erroneously attack the Myelin Basic Protein (MBP) on the surface of the Myelin cells • Well-studied protein; known which regions are immunogenic ...
Nobel Prize of physiology or medicine (1984) (4) Part I The
Nobel Prize of physiology or medicine (1984) (4) Part I The

... It was known that T cells & B cells communicate with each others. Jerns network theory (1974) postulated that the active sites of antibodies were attracted to both specific antigen (idiotype) & to other antibodies (anti-antibodies) to the same site The antibodies were imbalance until another antigen ...
Immune_11
Immune_11

... B-cell activated: antibody binds to antigen to mark it for destruction B-memory cells “remember” antigen in case of second infection Nooo! ...
Immunity - Honors
Immunity - Honors

... • 1st line of specific defense • Help recruit other immune cells & tell them to attack certain invaders ...
1. Describe the first non-specific line of defense the
1. Describe the first non-specific line of defense the

... B  memory cells which bear receptors specific for that antigen for a long time - called “cloning selection”  ...
Immune System Reading Notes Nonspecific Defenses and External
Immune System Reading Notes Nonspecific Defenses and External

Immune Memory and Vaccines
Immune Memory and Vaccines

... gene combination for a specific antibody), most will never encounter an antigen that their antibody or BCR “recognize” or that causes them to activate • For those who do, they begin undergoing mitosis, forming clones or cells that have the exact same antibody (or BCR) gene combination • The clone ce ...
File
File

... Marcophages recognize whether the cell is self or not-self – 2. Recognition is based on protein molecules that make up part of the surface of all cells & viruses 3. found in and outside the bloodstream C. Inflammatory Response 1. Local injury or infection 1. vasodilation near injury or infection inc ...
IMMUNE SYSTEM:
IMMUNE SYSTEM:

... 1. Barriers like your skin keep pathogens from getting into your body. Pathogens cause disease. 2. If pathogens get past the barrier of your skin, the inflammatory response helps attack the pathogens. It is called the body’s general defense. 3. A white blood cell that surrounds the pathogen and dest ...
Study guid Ch 15
Study guid Ch 15

... Is the adaptive immune response generally faster or slower than the innate? What are the two branches of the immune system? T cells and B cells are lymphocytes and largely responsible for the activities of the adaptive immune system. What are antigen presenting cells and what do they do? What is pha ...
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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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