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Immunity and Autoimmune Disease
Immunity and Autoimmune Disease

... www.ncbi.nlm.nih.gov/ www.niaid.nih.gov/publications/autoimmune/autoimmune.html ...
File - Pennington AP Biology
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... Essential knowledge 3.D.2: Cells communicate with each other through direct contact with other cells or from a distance via chemical signaling. • a. Cells communicate by cell-to-cell contact. – Immune cells interact by cell-cell contact, and killer Tcells. Interaction of Antigen Presenting Cells an ...
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Powerpoint - UCSF Immunology Program

... • Adaptive immunity learns from previous experience and hence can protect better upon a second infection by the same agent. • Adaptive immunity has a very large number of distinct “antigen receptors” of T and B lymphocytes; generated by DNA rearrangements in each developing lymphocyte; clonal select ...
Microbiology 204: Cellular and Molecular Immunology
Microbiology 204: Cellular and Molecular Immunology

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Kuby Immunology 6/e

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Southern Methodist University

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...  Progressive muscle weakness. Antibodies block acetylcholine receptors at neuromuscular synapse.  Affects 25,000 Americans (mainly women).  Today most patients survive when treated with drugs or immunosuppressants. ...
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... This cell line known as Epithelioma papulosum cyprini (EPC) was originally reported to be from Carp (Cyprinus carpio) epidermal herpes virus-induced hyperplastic lesions. More recently EPC was found to be derived from Fathead Minnow (Pimephales promelas) see Winton et al., 2010. This has been confir ...
Auto-immune diseases – 19/03/03
Auto-immune diseases – 19/03/03

... Auto-immune diseases – 19/03/03 General information Basically, the immune system does not react to host cells. This is because it exhibits immunologic tolerance. Its ability to discriminate self from non-self is one of its cardinal features. If this is partially/fully lost, then you get self antigen ...
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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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