Pemphigus pathogenesis - Welcome!
... -Initially 2 cycles of rituximab given once weekly for 3 weeks and IVIg given in the 4th week; followed by monthly infusion of rituximab and IVIg for 4 consecutive months -Of 11 patients, 9 had complete and rapid resolution of lesions and a clinical remission lasting an average of 31 months. All imm ...
... -Initially 2 cycles of rituximab given once weekly for 3 weeks and IVIg given in the 4th week; followed by monthly infusion of rituximab and IVIg for 4 consecutive months -Of 11 patients, 9 had complete and rapid resolution of lesions and a clinical remission lasting an average of 31 months. All imm ...
MLAB 1315- Hematology Fall 2007 Keri Brophy
... the production and development of myeloid cells in the bone marrow ...
... the production and development of myeloid cells in the bone marrow ...
Pathogenic biofilm - Holistic Family Dentistry Steven N. Green, DDS
... However, since multiple species are present in most natural environments, we also need models that allow monitoring of possible antagonistic or synergistic interactions between community members (and even these copies cannot take the state of an individual host’s immune system into account). A diffu ...
... However, since multiple species are present in most natural environments, we also need models that allow monitoring of possible antagonistic or synergistic interactions between community members (and even these copies cannot take the state of an individual host’s immune system into account). A diffu ...
Introduction to AIS
... not self and defense against foreign organisms or substances (Dorland's Illustrated Medical Dictionary) The immune system is a cognitive system whose primary role is to provide body maintenance ...
... not self and defense against foreign organisms or substances (Dorland's Illustrated Medical Dictionary) The immune system is a cognitive system whose primary role is to provide body maintenance ...
The amphioxus immune system
... the MHC class I genes, named MHC class III region, which includes genes coding for the complement system and some members of the tumor necrosis factor (TNF) family (Flajnik and Du Pasquier, 2004). Moreover, further genes involved in MHC presentation have been found within the socalled MHC class I an ...
... the MHC class I genes, named MHC class III region, which includes genes coding for the complement system and some members of the tumor necrosis factor (TNF) family (Flajnik and Du Pasquier, 2004). Moreover, further genes involved in MHC presentation have been found within the socalled MHC class I an ...
Langerhans Cell Histiocytosis on the Vulva: A Case Report and
... the S-100 protein must be found, or the histiocytic cells in lesions consistent with LCH must be found to be positive for CD1 antibodies[3]. LCH is a very rare disease. The pathogenesis of most histiocytoses remains unclear. A possible cytokine-related pathway[4] and a potential role of granulocyte- ...
... the S-100 protein must be found, or the histiocytic cells in lesions consistent with LCH must be found to be positive for CD1 antibodies[3]. LCH is a very rare disease. The pathogenesis of most histiocytoses remains unclear. A possible cytokine-related pathway[4] and a potential role of granulocyte- ...
Expanding roles for CD4+ T cells in immunity to viruses
... almost exclusively on their ability to generate strong neutralizing antibody responses. Antibody-mediated protection can be extraordinarily long-lived 33, and neutralizing antibodies present at the time of pathogen encounter can prevent rather than combat infection, thereby achieving ‘sterilizing’ i ...
... almost exclusively on their ability to generate strong neutralizing antibody responses. Antibody-mediated protection can be extraordinarily long-lived 33, and neutralizing antibodies present at the time of pathogen encounter can prevent rather than combat infection, thereby achieving ‘sterilizing’ i ...
GABAergic System in b-Cells: From Autoimmunity Target
... GABA, baclofen, and muscimol reduced the percentage of apoptotic islet cells in dose-dependent mice (Fig. 1). To strengthen their hypothesis, Tian et al. next examined whether GABA administration limited b-cell apoptosis in a model of human islet transplantation. Two days following islet transplant, ...
... GABA, baclofen, and muscimol reduced the percentage of apoptotic islet cells in dose-dependent mice (Fig. 1). To strengthen their hypothesis, Tian et al. next examined whether GABA administration limited b-cell apoptosis in a model of human islet transplantation. Two days following islet transplant, ...
Roles of dopamine receptor subtypes in
... Dopamine receptors have been isolated, characterized and subdivided into two families, D1-like and D2-like receptors, on the basis of their biochemical and pharmacological properties (Vallone et al. 2000). The dopamine D1-like receptor family comprises D1 receptors (D1R) and D5R, and the D2-like rec ...
... Dopamine receptors have been isolated, characterized and subdivided into two families, D1-like and D2-like receptors, on the basis of their biochemical and pharmacological properties (Vallone et al. 2000). The dopamine D1-like receptor family comprises D1 receptors (D1R) and D5R, and the D2-like rec ...
Regeneration or scarring: An immunologic perspective
... in the mother’s pouch. Despite the absence of a sterile aqueous environment, incisional wounds in newborn opossums heal with minimal inflammation and no scars (Armstrong and Ferguson, 1995). Conversely, it was shown, that sheep skin from an adult or late fetus grafted onto a young fetus and subsequen ...
... in the mother’s pouch. Despite the absence of a sterile aqueous environment, incisional wounds in newborn opossums heal with minimal inflammation and no scars (Armstrong and Ferguson, 1995). Conversely, it was shown, that sheep skin from an adult or late fetus grafted onto a young fetus and subsequen ...
STATE OF THE SCIENCE REPORT
... macroscale. For instance, there is more pressure in a small droplet of water than a larger one, because at the microscale, surface tension dominates over gravity. Thus, microscale physics can be leveraged for these unique properties. Dr. David Beebe discussed creating a microscale platform for s ...
... macroscale. For instance, there is more pressure in a small droplet of water than a larger one, because at the microscale, surface tension dominates over gravity. Thus, microscale physics can be leveraged for these unique properties. Dr. David Beebe discussed creating a microscale platform for s ...
Mycobacterium bovis Subsets following Infection with Virulent T Cell
... M. bovis–infected animals proliferate and produce IFN-g in specific and direct response to complex, as well as defined, nonprotein and protein mycobacterial Ags but that WC1.2+ gd T cells predominate in the lung lesions of animals infected with virulent strains of M. bovis. Importantly, to our knowl ...
... M. bovis–infected animals proliferate and produce IFN-g in specific and direct response to complex, as well as defined, nonprotein and protein mycobacterial Ags but that WC1.2+ gd T cells predominate in the lung lesions of animals infected with virulent strains of M. bovis. Importantly, to our knowl ...
Doctoral thesis from the Department of Immunology,
... incidence of 2 million new cases per year (0.5 million of visceral leishmaniasis (VL) and l.5 million of cutaneous leishmaniasis (CL). VL causes an estimated more than 50 000 deaths annually and 2 357 000 disability-adjusted life years lost, placing leishmaniasis ninth in a global analysis of infect ...
... incidence of 2 million new cases per year (0.5 million of visceral leishmaniasis (VL) and l.5 million of cutaneous leishmaniasis (CL). VL causes an estimated more than 50 000 deaths annually and 2 357 000 disability-adjusted life years lost, placing leishmaniasis ninth in a global analysis of infect ...
TLR3 Signaling in Macrophages Is Indispensable for the
... (TCR) and share a number of cell surface markers in common with NK cells. iNKT cells recognize glycolipid antigens presented by the invariant MHC class I-like molecule CD1d, which is expressed mainly on dendritic cells (DCs) and macrophages. Following lipid antigen stimulation, iNKT cells express CD ...
... (TCR) and share a number of cell surface markers in common with NK cells. iNKT cells recognize glycolipid antigens presented by the invariant MHC class I-like molecule CD1d, which is expressed mainly on dendritic cells (DCs) and macrophages. Following lipid antigen stimulation, iNKT cells express CD ...
Gastric Cancer Prevention
... Gastric Cancer: Risk Factors and Primary Prevention • Gastric Cancer is a very common disease that carries a high mortality. • The diagnosis in early phases, when better results should be expected, is difficult due to the unspecifity of early symptoms. ...
... Gastric Cancer: Risk Factors and Primary Prevention • Gastric Cancer is a very common disease that carries a high mortality. • The diagnosis in early phases, when better results should be expected, is difficult due to the unspecifity of early symptoms. ...
PowerPoint® Lecture Presentations prepared by Jason LaPres
... basis for ABO and Rh incompatibilities. • 19-5 Categorize white blood cell types based on their structures and functions, and discuss the factors that regulate the production of each type. • 19-6 Describe the structure, function, and production of platelets. • 19-7 Discuss the mechanisms that contro ...
... basis for ABO and Rh incompatibilities. • 19-5 Categorize white blood cell types based on their structures and functions, and discuss the factors that regulate the production of each type. • 19-6 Describe the structure, function, and production of platelets. • 19-7 Discuss the mechanisms that contro ...
Role of C-C chemokine receptor type 7 and its ligands during
... more potent than CCL21 for DC chemotaxis [38], and is also a more potent chemoattractant than CXCL12 for activated T cells [57]. By contrast, another recent study used microfluidics-based approaches to generate chemokine gradients on three-dimensional (3D) matrices mimicking the 3D tissue environmen ...
... more potent than CCL21 for DC chemotaxis [38], and is also a more potent chemoattractant than CXCL12 for activated T cells [57]. By contrast, another recent study used microfluidics-based approaches to generate chemokine gradients on three-dimensional (3D) matrices mimicking the 3D tissue environmen ...
Inflammation and Cellular Immune Responses in Abdominal Aortic
... Occlusive and Aneurysmal Disease Most AAA occur in the context of atherosclerosis, and all stages of atheromata contain T lymphocytes, with a predominance of CD4⫹ helper T cells.34,64,68 T cells and macrophages may affect atherogenesis by producing various cytokines that induce either matrix synthes ...
... Occlusive and Aneurysmal Disease Most AAA occur in the context of atherosclerosis, and all stages of atheromata contain T lymphocytes, with a predominance of CD4⫹ helper T cells.34,64,68 T cells and macrophages may affect atherogenesis by producing various cytokines that induce either matrix synthes ...
ch_19_lecture_presentation
... • 19-4 Explain the importance of blood typing, and the basis for ABO and Rh incompatibilities. • 19-5 Categorize white blood cell types based on their structures and functions, and discuss the factors that regulate the production of each type. • 19-6 Describe the structure, function, and production ...
... • 19-4 Explain the importance of blood typing, and the basis for ABO and Rh incompatibilities. • 19-5 Categorize white blood cell types based on their structures and functions, and discuss the factors that regulate the production of each type. • 19-6 Describe the structure, function, and production ...
The Usefulness of Rabbit Anti-QQQPP Peptide Antibodies to Wheat
... of creation of peptides with opiate activities or many other biological activities, for example other allergens. It can also cause a decrease in organoleptic quality of the product. Such a risk does not exist in the case of using transglutaminase to decrease the immunoreactivity. Transglutaminase ma ...
... of creation of peptides with opiate activities or many other biological activities, for example other allergens. It can also cause a decrease in organoleptic quality of the product. Such a risk does not exist in the case of using transglutaminase to decrease the immunoreactivity. Transglutaminase ma ...
INNOVATIONS IN CANCER RESEARCH
... It’s Time A second film, It’s Time, was also developed as a non-fictional nonnarrative alternative to Tamale Lesson. This film took a more traditional approach and involved doctors and health experts discussing the same key facts surrounding HPV and cervical cancer. It also includes a demonstration ...
... It’s Time A second film, It’s Time, was also developed as a non-fictional nonnarrative alternative to Tamale Lesson. This film took a more traditional approach and involved doctors and health experts discussing the same key facts surrounding HPV and cervical cancer. It also includes a demonstration ...
Immunogold Labeling of Rosette Terminal Cellulose
... bulk cytoplasm attached to the replicas, allowing the replicas to be clearly viewed. Replicas obtained in this manner appear similar to those obtained by using conventional freeze-fracture techniques, in which harsh acid treatments customarily have been used to remove cell and tissue components. Ant ...
... bulk cytoplasm attached to the replicas, allowing the replicas to be clearly viewed. Replicas obtained in this manner appear similar to those obtained by using conventional freeze-fracture techniques, in which harsh acid treatments customarily have been used to remove cell and tissue components. Ant ...
Management Of Cold Haemolytic Syndrome
... A transgenic strain of mice that expresses a pathogenic human cold agglutinin has been developed (Havouis et al, 2002). Experimental infections of these mice with mycoplasma resulted in a high antimycoplasma antibody response and induction of cold agglutinin production in the serum. This animal mode ...
... A transgenic strain of mice that expresses a pathogenic human cold agglutinin has been developed (Havouis et al, 2002). Experimental infections of these mice with mycoplasma resulted in a high antimycoplasma antibody response and induction of cold agglutinin production in the serum. This animal mode ...
Enhancement of Epithelial Barrier Function by Probiotics
... structural components, and microbial-produced metabolites. In particular, the NF-kB pathway is modulated by probiotics at many different levels with effects seen on IB degradation and ubiquitination, proteasome function, and nuclearcytoplasmic movement of RelA through a PPAR-gamma dependent pathway ...
... structural components, and microbial-produced metabolites. In particular, the NF-kB pathway is modulated by probiotics at many different levels with effects seen on IB degradation and ubiquitination, proteasome function, and nuclearcytoplasmic movement of RelA through a PPAR-gamma dependent pathway ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.