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The ontogeny of the common carp (Cyprinus carpio L.) immune system
... Expression of the innate immune factors complement factor 3 (C3), α2macroglobulin (α2M), serum amyloid A (SAA) and a complement factor 1 r/s - mannose binding lectin associated serine protease-like molecule (C1/MASP2) was determined with real time quantitative PCR in carp (Cyprinus carpio L.) ontoge ...
... Expression of the innate immune factors complement factor 3 (C3), α2macroglobulin (α2M), serum amyloid A (SAA) and a complement factor 1 r/s - mannose binding lectin associated serine protease-like molecule (C1/MASP2) was determined with real time quantitative PCR in carp (Cyprinus carpio L.) ontoge ...
WCIT 2010-Invitation Letter1
... 2010 (WCIT-2010) with the theme of “Boosting Health and Vitality”, which will take place in Beijing, China on May 15-17, 2010. With your great contributions in the study and research on immunology, you are expected to take part in this international and compositive conference. The program track info ...
... 2010 (WCIT-2010) with the theme of “Boosting Health and Vitality”, which will take place in Beijing, China on May 15-17, 2010. With your great contributions in the study and research on immunology, you are expected to take part in this international and compositive conference. The program track info ...
NATURAL KILLER CELL ANTIBODY RECEPTOR ENGAGEMENT
... immunosuppression, ABMR remains difficult to control and is thus the major cause of late allograft failure (1). TCMR is perpetuated by the effects of T cell-derived soluble mediators and cell lysis mediated by CD8 T cells (CTL) against targets bearing donor antigens on class I HLA. Conversely, ABMR ...
... immunosuppression, ABMR remains difficult to control and is thus the major cause of late allograft failure (1). TCMR is perpetuated by the effects of T cell-derived soluble mediators and cell lysis mediated by CD8 T cells (CTL) against targets bearing donor antigens on class I HLA. Conversely, ABMR ...
ABSTRACT Title of Document:
... provides the initial protection, following which it facilitates the activation of the adaptive ...
... provides the initial protection, following which it facilitates the activation of the adaptive ...
Immune profile from high-risk to onset of Type 1 diabetes No. 1275
... years post diagnosis. In addition, we wanted to efficiently expand Tregs and detect any difference in T cell number and composition among T1D, high-risk and healthy individuals. We found that high-risk individuals that later developed T1D had a lower mRNA expression of the regulatory associated mark ...
... years post diagnosis. In addition, we wanted to efficiently expand Tregs and detect any difference in T cell number and composition among T1D, high-risk and healthy individuals. We found that high-risk individuals that later developed T1D had a lower mRNA expression of the regulatory associated mark ...
MONOCYTE AND MACROPHAGE HETEROGENEITY
... CD62L+CX3CR1lowLy6C+ mouse monocytes correspond to CD14hiCD16– (classic) human monocytes, which are also CCR2 + CX 3 CR1 low and that CCR2 – CD62L–CX3CR1hiLy6C– mouse monocytes correspond to CD14+CD16+CD64 – human monocytes, which also express large amounts of CX3CR1. These observations were the fir ...
... CD62L+CX3CR1lowLy6C+ mouse monocytes correspond to CD14hiCD16– (classic) human monocytes, which are also CCR2 + CX 3 CR1 low and that CCR2 – CD62L–CX3CR1hiLy6C– mouse monocytes correspond to CD14+CD16+CD64 – human monocytes, which also express large amounts of CX3CR1. These observations were the fir ...
ICH E10
... human pharmaceuticals are currently available for testing for respiratory or systemic allergenicity (antigenicity) or drug-specific autoimmunity; testing for these endpoints is not currently required in any region. There are no regional differences in testing approaches of skin sensitization. Immuno ...
... human pharmaceuticals are currently available for testing for respiratory or systemic allergenicity (antigenicity) or drug-specific autoimmunity; testing for these endpoints is not currently required in any region. There are no regional differences in testing approaches of skin sensitization. Immuno ...
The role of different monocyte subsets and macrophages in asthma
... suggested to be have independently accounted for development of airway hyper-responsiveness ...
... suggested to be have independently accounted for development of airway hyper-responsiveness ...
Modulating impact of human chorionic gonadotropin hormone on the maturation
... circumstance where self-tolerance plays a determining role in fetal maintenance. Moreover, many study groups regard Tregs to be actively engaged, not only in the prevention of autoimmunity but also in facilitating transplantation tolerance; targeting them therapeutically may help to potentiate tumor ...
... circumstance where self-tolerance plays a determining role in fetal maintenance. Moreover, many study groups regard Tregs to be actively engaged, not only in the prevention of autoimmunity but also in facilitating transplantation tolerance; targeting them therapeutically may help to potentiate tumor ...
Adlai E. Stevenson High School Course Description
... Explain the role of cytotoxic T-Cells in cell-mediated immunity (figures 43.16, 43.17, 43.18) Explain the role of MHC (class I MHC and class II MHC), antigen-presenting Cells (APC), T-helper Cells, and cytokines for the initiation of a specific immune response. (figures 43.12, 43.16, 43.17) Explore ...
... Explain the role of cytotoxic T-Cells in cell-mediated immunity (figures 43.16, 43.17, 43.18) Explain the role of MHC (class I MHC and class II MHC), antigen-presenting Cells (APC), T-helper Cells, and cytokines for the initiation of a specific immune response. (figures 43.12, 43.16, 43.17) Explore ...
Complement-targeted therapeutics
... Figure 2 Activation, regulation and therapeutic modulation of the complement system. (a) The complement cascade after activation by pathogens. In addition to a low level of constant activation by the alternative pathway (AP; tick-over via hydrolyzed C3 (C3w) results in the formation of the initial C ...
... Figure 2 Activation, regulation and therapeutic modulation of the complement system. (a) The complement cascade after activation by pathogens. In addition to a low level of constant activation by the alternative pathway (AP; tick-over via hydrolyzed C3 (C3w) results in the formation of the initial C ...
xia immune activation 1
... A, Real-time reverse transcription polymerase chain reaction analysis of Rae-1␦, Rae-1⑀, and H60b transcripts in RNA samples isolated from aortic arch regions of Western diet (WD)–fed ApoE⫺/⫺ mice. Samples of age-matched WD- and chow-fed wild-type (WT) mice were used as controls. The experiment incl ...
... A, Real-time reverse transcription polymerase chain reaction analysis of Rae-1␦, Rae-1⑀, and H60b transcripts in RNA samples isolated from aortic arch regions of Western diet (WD)–fed ApoE⫺/⫺ mice. Samples of age-matched WD- and chow-fed wild-type (WT) mice were used as controls. The experiment incl ...
case report measles-mumps-rubella vaccination induced
... in a faster increase in platelet counts. Intravenous immunoglobulin, which blocks Fc-receptors on the macrophages of the reticuloendothelial system, is also the first line treatment for ITP in an emergency setting and proves effective when used at a high dose of 1-2 g/kg (Labarque and Van Geet, 2014 ...
... in a faster increase in platelet counts. Intravenous immunoglobulin, which blocks Fc-receptors on the macrophages of the reticuloendothelial system, is also the first line treatment for ITP in an emergency setting and proves effective when used at a high dose of 1-2 g/kg (Labarque and Van Geet, 2014 ...
SERIES "RECENT DEVELOPMENTS IN PULMONARY INFECTIONS" Number 5 in this Series
... In vivo T-helper (Th)1 or Th2 cells act in concert with CD8z cells, and with numerous other cell types including macrophages, B cells and some stromal cells. Collectively these give rise to two patterns of cytokine release known as Type 1 (dominated by interleukin-2 (IL-2), interleukin-12 (IL-12), a ...
... In vivo T-helper (Th)1 or Th2 cells act in concert with CD8z cells, and with numerous other cell types including macrophages, B cells and some stromal cells. Collectively these give rise to two patterns of cytokine release known as Type 1 (dominated by interleukin-2 (IL-2), interleukin-12 (IL-12), a ...
Tissue after Acute Infection Ex Vivo Cytokine Gene Expression in
... Many reported in vitro findings are difficult to extrapolate to the in vivo situation. They were obtained in PBMC activated with Abs or polyclonal mitogens, monocyte-derived macrophages, or cell lines exposed to a high virus input or recombinant HIV proteins. However, the cytokine milieu generated i ...
... Many reported in vitro findings are difficult to extrapolate to the in vivo situation. They were obtained in PBMC activated with Abs or polyclonal mitogens, monocyte-derived macrophages, or cell lines exposed to a high virus input or recombinant HIV proteins. However, the cytokine milieu generated i ...
Temeyer 2016 tick salivary cholinesterase
... Acetylthiocholine delivered to unfed female ticks by microinjection resulted in rapid tick paralysis at final equivalent concentrations of 1–10 mM, while lesser concentrations resulted in slowed movement and rapid onset of copious salivation. After 3 h, approximately 50% of ticks exposed at calculat ...
... Acetylthiocholine delivered to unfed female ticks by microinjection resulted in rapid tick paralysis at final equivalent concentrations of 1–10 mM, while lesser concentrations resulted in slowed movement and rapid onset of copious salivation. After 3 h, approximately 50% of ticks exposed at calculat ...
Plasma Membrane Profiling Defines an Expanded Class of
... HCMV is the prototype betaherpesvirus and an important human pathogen. Following primary infection, HCMV persists for the lifetime of the host under constant control by the host immune system. In the face of this selective pressure, HCMV has evolved multiple mechanisms to evade immune detection and ...
... HCMV is the prototype betaherpesvirus and an important human pathogen. Following primary infection, HCMV persists for the lifetime of the host under constant control by the host immune system. In the face of this selective pressure, HCMV has evolved multiple mechanisms to evade immune detection and ...
The role of heat shock proteins in reproduction
... The amino acid composition of HSP has not changed very much during evolution. HSP of highly divergent organisms are very similar to one another (their structure has been conserved). Some members of the HSP families are strictly inducible by stress, whereas others are constitutively expressed at norm ...
... The amino acid composition of HSP has not changed very much during evolution. HSP of highly divergent organisms are very similar to one another (their structure has been conserved). Some members of the HSP families are strictly inducible by stress, whereas others are constitutively expressed at norm ...
Pathways Molecule-Dependent and
... receptors (CCR2, CCR5, and CCR7), and enhanced Ag presentation (6, 7). Because these events are crucial in the development of optimal antiviral responses, many viruses target these events to prevent the development of antiviral immunity and boost viral survival. The recognition mechanisms that initi ...
... receptors (CCR2, CCR5, and CCR7), and enhanced Ag presentation (6, 7). Because these events are crucial in the development of optimal antiviral responses, many viruses target these events to prevent the development of antiviral immunity and boost viral survival. The recognition mechanisms that initi ...
A1 - Ummafrapp
... Shifts in microbial communities are implicated in the pathogenesis of a number of gastrointestinal diseases, but we have limited understanding of the mechanisms that lead to altered community structures. One difficulty with studying these mechanisms in human subjects is the inherent baseline variabi ...
... Shifts in microbial communities are implicated in the pathogenesis of a number of gastrointestinal diseases, but we have limited understanding of the mechanisms that lead to altered community structures. One difficulty with studying these mechanisms in human subjects is the inherent baseline variabi ...
Th1, Th2 and Treg associated factors in relation to allergy Camilla Janefjord
... lymphocyte function-associated antigen mitogen-activated protein kinase major histocompatibility complex messenger ribonucleic acid natural killer cell non-obese diabetic mice no template control peripheral blood mononuclear cells polymerase chain reaction phytohaemagglutinin repressor of GATA ribos ...
... lymphocyte function-associated antigen mitogen-activated protein kinase major histocompatibility complex messenger ribonucleic acid natural killer cell non-obese diabetic mice no template control peripheral blood mononuclear cells polymerase chain reaction phytohaemagglutinin repressor of GATA ribos ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.