The Role of Intracellular Neutral Lipid Hydrolases in Immune Cell
... I would like to thank my supervisor Dagmar Kratky for her guidance, motivation and comprehensive support, for the trust in my ideas throughout my PhD project and for always having an open door. I owe my gratitude to the thesis committee members Akos Heinemann, Achim Lass and Ruth Birner-Gruenberger ...
... I would like to thank my supervisor Dagmar Kratky for her guidance, motivation and comprehensive support, for the trust in my ideas throughout my PhD project and for always having an open door. I owe my gratitude to the thesis committee members Akos Heinemann, Achim Lass and Ruth Birner-Gruenberger ...
R e v i s i ó n
... well as cellular ligands (4). Classically, subfamilies have been distinguished depending on the β subunit present in the heterodimer. Thus, β1 subfamily contains members that mainly recognize ECM proteins such as fibronectin, collagen, laminin, and others except α4β1 and α9β1 that can also bind the ...
... well as cellular ligands (4). Classically, subfamilies have been distinguished depending on the β subunit present in the heterodimer. Thus, β1 subfamily contains members that mainly recognize ECM proteins such as fibronectin, collagen, laminin, and others except α4β1 and α9β1 that can also bind the ...
Consumption of Rice Bran Increases Mucosal
... on control diet. No significant differences were detected in T or B cell populations (Table 3). These data suggested that rice bran–mediated induction of dendritic cell recruitment into the mucosal tissues resulted in increased antigen presentation and subsequent IgA production. Dietary rice bran in ...
... on control diet. No significant differences were detected in T or B cell populations (Table 3). These data suggested that rice bran–mediated induction of dendritic cell recruitment into the mucosal tissues resulted in increased antigen presentation and subsequent IgA production. Dietary rice bran in ...
Th1/Th2 Balance - Alternative Medicine Review
... ing and functionally integrating its numerous cell that travel to other cells (both immune and types for rapid response. The Th1/Th2 hypothesis nonimmune) and stimulate those cells to become in its modern incarnation endows these two types either more active (up-regulated) or less active of immune c ...
... ing and functionally integrating its numerous cell that travel to other cells (both immune and types for rapid response. The Th1/Th2 hypothesis nonimmune) and stimulate those cells to become in its modern incarnation endows these two types either more active (up-regulated) or less active of immune c ...
Unmasking tuberculosis in the era of antiretroviral treatment PERSPECTIVE
... programmes in high TB burden areas, mainly in southern Africa, has been associated with an unexpectedly high occurrence of TB during the first 3 months of cART, suggesting a potential role of cART-driven immune restoration in ‘‘unmasking’’ subclinical TB [3]. The underlying mechanisms through which ...
... programmes in high TB burden areas, mainly in southern Africa, has been associated with an unexpectedly high occurrence of TB during the first 3 months of cART, suggesting a potential role of cART-driven immune restoration in ‘‘unmasking’’ subclinical TB [3]. The underlying mechanisms through which ...
Hall - Autism Speaks
... that share a common behavioral profile. To make progress in identifying the causes of these disorders it will be essential to develop diagnostic markers that will lead to unequivocal differentiation of the various phenotypes. One area that has consistently been discussed as an important factor in au ...
... that share a common behavioral profile. To make progress in identifying the causes of these disorders it will be essential to develop diagnostic markers that will lead to unequivocal differentiation of the various phenotypes. One area that has consistently been discussed as an important factor in au ...
Full Text - Avicenna Journal of Dental Research
... H. pylori antigen-presenting cells have interactions with CD4-expressing cells, which bind to B-cells in the marginal zone leading to T-cell activation, lymphoid follicle formation, and B-cell proliferation in gastric mucosa and therefore development of gastric lymphoma (38). Patients with SS also h ...
... H. pylori antigen-presenting cells have interactions with CD4-expressing cells, which bind to B-cells in the marginal zone leading to T-cell activation, lymphoid follicle formation, and B-cell proliferation in gastric mucosa and therefore development of gastric lymphoma (38). Patients with SS also h ...
Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome
... control) and Salp15. As negative control beads we used antibody (anti-V5) coated beads. Immature DCs were incubated with the ligands and binding was measured by FACS analysis. Specificity was determined by preincubation of DCs with EDTA or mannan (significance determined by a two-sided one way ANOVA ...
... control) and Salp15. As negative control beads we used antibody (anti-V5) coated beads. Immature DCs were incubated with the ligands and binding was measured by FACS analysis. Specificity was determined by preincubation of DCs with EDTA or mannan (significance determined by a two-sided one way ANOVA ...
RCAI Annual Report 2011 (PDF 34.1M)
... Functional and developmental heterogeneity of invariant natural killer T cells. . . . . . . . . . . . . 14 Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation in mice. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
... Functional and developmental heterogeneity of invariant natural killer T cells. . . . . . . . . . . . . 14 Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation in mice. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
Activation-induced Cytidine Deaminase in B Cell Immunity and
... are important for the introduction of S region DSBs. AID binds cooperatively with UNG and Msh2-Msh6 to Ig S regions, and this depends on the AID carboxyl-terminus. Stavnezer's group demonstrated that the ability of AID to recruit UNG and Msh2-Msh6 proteins is important for DSB resolution during Ig C ...
... are important for the introduction of S region DSBs. AID binds cooperatively with UNG and Msh2-Msh6 to Ig S regions, and this depends on the AID carboxyl-terminus. Stavnezer's group demonstrated that the ability of AID to recruit UNG and Msh2-Msh6 proteins is important for DSB resolution during Ig C ...
Autoimmune Responses to the Brain After Stroke Are Associated
... In this study, we defined a Th1(⫹) response to an antigen as a response that was ⬎75% percentile of the control response to that antigen. Patients with more severe strokes (NIHSS ⱖ17) were more likely to develop Th1(⫹) responses to PLP (P⫽0.026) and MBP (P⬍0.001) than patients with less severe strok ...
... In this study, we defined a Th1(⫹) response to an antigen as a response that was ⬎75% percentile of the control response to that antigen. Patients with more severe strokes (NIHSS ⱖ17) were more likely to develop Th1(⫹) responses to PLP (P⫽0.026) and MBP (P⬍0.001) than patients with less severe strok ...
Vitamin D deficiency(common) - Rajiv Gandhi University of Health
... Non classical actions of vitamin D were first recognized 30 years ago when receptors for active vitamin D3 were detected in various neoplastic cell lines (8). Other studies followed, showing that binding of the vitamin D3 to the Vitamin D receptor (VDR) promoted anti proliferative and prodifferentia ...
... Non classical actions of vitamin D were first recognized 30 years ago when receptors for active vitamin D3 were detected in various neoplastic cell lines (8). Other studies followed, showing that binding of the vitamin D3 to the Vitamin D receptor (VDR) promoted anti proliferative and prodifferentia ...
nk cell education and adhesion molecules
... B cells, dendritic cells (DC) and macrophages [1]. Therapy strategies that are based on the immune system include hematopoietic stem cell transplantation (HSCT) and adoptive transfer of specific immune cells, treatment with immune activating cytokines, vaccination, monoclonal antibodies (mAb) specif ...
... B cells, dendritic cells (DC) and macrophages [1]. Therapy strategies that are based on the immune system include hematopoietic stem cell transplantation (HSCT) and adoptive transfer of specific immune cells, treatment with immune activating cytokines, vaccination, monoclonal antibodies (mAb) specif ...
oral graft versus host disease
... In patients with xerostomia, the available treatment options, such as salivary substitutes, are largely palliative and usually offer only short-term relief. Pilocarpine, a cholinergic agonist, has been long known to stimulate salivary secretion. Additionally, careful diagnosis and appropriate treat ...
... In patients with xerostomia, the available treatment options, such as salivary substitutes, are largely palliative and usually offer only short-term relief. Pilocarpine, a cholinergic agonist, has been long known to stimulate salivary secretion. Additionally, careful diagnosis and appropriate treat ...
Licentiate thesis from the Department of Immunology,
... lytic enzymes in the lysosome 34; apoptosis 24 of infected macrophages which removes the niche for growth and therefore restricts multiplication of bacteria. ...
... lytic enzymes in the lysosome 34; apoptosis 24 of infected macrophages which removes the niche for growth and therefore restricts multiplication of bacteria. ...
Pathogenesis of the Helicobacter Induced Mucosal Disease: A
... inflammation. Human studies looking at single nucleotide polymorphism of cytokines, like IL-1β, IL-10 and TNF-α have clearly demonstrated how genotypes that result in high levels of IL-1β and TNF-α, but low IL-10 expression may confer a 50-fold higher risk in developing gastric cancer. The outcome ...
... inflammation. Human studies looking at single nucleotide polymorphism of cytokines, like IL-1β, IL-10 and TNF-α have clearly demonstrated how genotypes that result in high levels of IL-1β and TNF-α, but low IL-10 expression may confer a 50-fold higher risk in developing gastric cancer. The outcome ...
Characterisation of interleukin-10 expression on different vascular
... vascular anatomy. It consists of a dense subepithelial network of capillaries, a system of capacitance vessels or sinusoids and arteriovenous anastomoses; the arteries/ veins. Vascular activities are involved both in the mucosal defence and physiological functions of the nose, thereby also contribut ...
... vascular anatomy. It consists of a dense subepithelial network of capillaries, a system of capacitance vessels or sinusoids and arteriovenous anastomoses; the arteries/ veins. Vascular activities are involved both in the mucosal defence and physiological functions of the nose, thereby also contribut ...
¿Manipulan los ácaros el sistema inmunológico?
... • The synergistic effects of biologically active enzyme allergens on Th2 responses and allergic inflammation may explain why mites are the predominant allergens associated with asthma. • A central paradox remains that other important asthma-associated allergens (eg., cockroach and animal allergens) ...
... • The synergistic effects of biologically active enzyme allergens on Th2 responses and allergic inflammation may explain why mites are the predominant allergens associated with asthma. • A central paradox remains that other important asthma-associated allergens (eg., cockroach and animal allergens) ...
Infection T Cell Response during Chronic Viral +CD8 Exhaustion
... Induction of a monospecific antiviral CD8ⴙ T cell response may pose a risk to the host due to the narrow T cell response induced. At the individual level, this may result in selection of CD8ⴙ T cell escape variants, particularly during chronic viral infection. Second, prior immunization toward a sin ...
... Induction of a monospecific antiviral CD8ⴙ T cell response may pose a risk to the host due to the narrow T cell response induced. At the individual level, this may result in selection of CD8ⴙ T cell escape variants, particularly during chronic viral infection. Second, prior immunization toward a sin ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.