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Herpes viruses
Herpes viruses

...  Are ubiquitous and cause disease in plants and animals and are of economic importance.  Cause spectrum of diseases  Have ability for latency  Have ability for periodic activation  Also a vesicular rash is common except in CMV & EB viral diseases. ...
Hemolytic anemias
Hemolytic anemias

... • In a healthy person, a red blood cell survives 90 to 120 days in the circulation, so about 1% of human red blood cells break down each day. The bone marrow is the main organ that removes old and damaged RBCs from the circulation. In healthy individuals, the breakdown and removal of RBCs from the ...
Mechanisms of Danger-signal mediated Immune Modulation
Mechanisms of Danger-signal mediated Immune Modulation

The Human Immune System
The Human Immune System

... Macrophage engulfs the pathogen and displays the antigen for a T-cell T-cell learns pathogen and hunts out infected cells Once found, T-cells destroy infected cells (thru a process known as apoptosis) ...
Immunology: Animal Defense Systems
Immunology: Animal Defense Systems

... a TH cell binding to the exposed antigen on the B cell surface. The specific TH cell may come from a clone that was activated by the cellular immune response. Interaction between B cells and TH cells provides a connection between the cellular and humoral systems. The TH cell bound to the B cell secr ...
Comprehensive cancer care with a multidisciplinary approach
Comprehensive cancer care with a multidisciplinary approach

... of disease helps ensure that if a transplant is indicated, it is performed at an optimal time for the patient. We provide guidelines for timing of transplant consultation that specify which patients are at risk for disease progression and who should be referred for hematopoietic cell transplant. In ...
New Insights on Merkel Cell Carcinoma
New Insights on Merkel Cell Carcinoma

... Cyclic ADP ribose hydrolase; marker of T cell activation; functions in cell adhesion, signal transduction and calcium signaling ...
Concept Analysis Diagram
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Respiratory tract
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Blood Physiology Part 1 - e-SAFE
Blood Physiology Part 1 - e-SAFE

... of white cells, namely phagocytes and lymphocytes. Phagocytes are cells that engulf and destroy foreign material. They comprise monocytes (the precursors of macrophages) and granulocytes. Granulocytes consist of three cell types: neutrophils, eosinophils and basophils. Lymphocytes are the effector c ...
Blood Physiology – Part 1
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... of white cells, namely phagocytes and lymphocytes. Phagocytes are cells that engulf and destroy foreign material. They comprise monocytes (the precursors of macrophages) and granulocytes. Granulocytes consist of three cell types: neutrophils, eosinophils and basophils. Lymphocytes are the effector c ...
Presentation - Online Veterinary Anatomy Museum
Presentation - Online Veterinary Anatomy Museum

... a lymph node and all other lymphoid tissues. Label the connective tissue support represented by a capsule, trabeculae and reticular fibres. Also note the random scattering of lymphatic tissue (white pulp) centred around the branches of a central artery in the blood filled parenchyma called red pulp. ...
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... in subjects with evidence of active primary or metastatic lung cancer compared with those of subjects who had benign lung nodules and no evidence of active malignant disease. There was a statistically significant difference between mean SUV for organs noted above between the two groups (P<0.05). In ...
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... Laboratory in Edinburgh, Scotland revealed that cholesterol level reduces by 11 percent if seven ounces of raw carrots a day is taken for three weeks. High cholesterol is a major factor for heart disease. Since regular consumption of carrots reduces cholesterol level it is good to prevent heart rela ...
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... a) The antigen must be displayed to them by an antigen-presenting cell (APC), such as a dendritic cell or a macrophage. b) After phagocytizing a pathogen, APCs travel to a lymph node or the spleen where T cells congregate. c) The APC breaks the pathogen apart in a lysosome and displays a piece of th ...
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... And, there’s a growing body of clinical evidence to support including dietary interventions to support immune health on the training table. Whether you’re counseling a competitive or recreational athlete, stronger immunity can help keep them going strong. Immune health is of particular importance to ...
What is the importance of the immunological synapse? Daniel M. Davis
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... Self-assembly of protein clusters at the IS Specific patterns of MHC/KIR can assemble at an inhibitory NK-cell IS even in the presence of drugs that inhibit cytoskeletal or ATP-dependent processes [6,8]. Thus, supramolecular organization of some proteins can occur by mechanisms other than cytoskelet ...
Immunization www.AssignmentPoint.com Immunization, or
Immunization www.AssignmentPoint.com Immunization, or

... orchestrate an immune response, and it will also develop the ability to quickly respond to a subsequent encounter because of immunological memory. This is a function of the adaptive immune system. Therefore, by exposing an animal to an immunogen in a controlled way, its body can learn to protect its ...
Benchmark - Gulf Coast State College
Benchmark - Gulf Coast State College

... • Pathogens, cancer cells, or foreign cells have protein markers on surface (antigens) that activate the immune system because foreign to body Types of White Blood Cells - all made in the bone marrow - All called in after the non-specific WBCs –B lymphocyte cells (mature in bone marrow) • produce an ...
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Cancer immunotherapy



Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.
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