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Human Anatomy. Power Point - Panhandle Area Educational
Human Anatomy. Power Point - Panhandle Area Educational

... • Pathogens, cancer cells, or foreign cells have protein markers on surface (antigens) that activate the immune system because foreign to body Types of White Blood Cells - all made in the bone marrow - All called in after the non-specific WBCs –B lymphocyte cells (mature in bone marrow) • produce an ...
Immunization www.AssignmentPoint.com Immunization, or
Immunization www.AssignmentPoint.com Immunization, or

... orchestrate an immune response, and it will also develop the ability to quickly respond to a subsequent encounter because of immunological memory. This is a function of the adaptive immune system. Therefore, by exposing an animal to an immunogen in a controlled way, its body can learn to protect its ...
T memory cells in a model of cell memory
T memory cells in a model of cell memory

... • This new model has achieved its goal, the distinction between in vivo and in vitro situations. There may be some problems with it, but is so far the best represen tation of the population dynamics of T helper cells an d antigens in the human body and in a culture. • Possible problems: – In this mo ...
Viruses, cancer and aids
Viruses, cancer and aids

Blood group A
Blood group A

... • Some globulins are produced in the liver and are transport proteins for lipids, metal ions, and fat-soluble vitamins. • Other globulins are produced by plasma cells (a type of leukocyte) during the immune response. These globulins are also known as antibodies. – Clotting proteins • Most produced i ...
Vaccine
Vaccine

... adaptive immunity against fungal infections. – CD4+ and CD8+ T cells cooperate to eliminate the yeast ...
Roche`s TECENTRIQ (atezolizumab) shows significant survival
Roche`s TECENTRIQ (atezolizumab) shows significant survival

BONE MARROW FAILURE SYNDROMES
BONE MARROW FAILURE SYNDROMES

... Maj Gen (R) Masood Anwar ...
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... your own cells. When these agglutinins attack foreign RBC they bind to them and clump in a process called agglutination People w/out the Rh antigen (Rh-) don’t necessarily carry an antibody against Rh. This antibody is produced when a person is exposed to Rh. ...
Immune response and regulation 免疫应答(immune response, Ir)
Immune response and regulation 免疫应答(immune response, Ir)

... MHC restriction recognition of Tc * TCR recognize peptide/MHC-I on target cell; requirement for Tc activation ...
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Toxins produced by gram positive bacteria(2)

... After LLO lyses the phagosome, the bacterium escapes into the cytosol, where it can grow intracellularly. LLO permits L. monocytogenes to escape from phagosomes into the cytosol without damaging the plasma membrane of the infected cell. This allows the bacteria to live intracellularly, where they ar ...


... • Large groups of lymph nodes, found in the neck, groin, and armpits, swell when your body increases its production of white blood cells to fight infection. ...
Yukon Immunization Manual: Section 14
Yukon Immunization Manual: Section 14

...  The most abundant class of antibody, constituting approximately 80% of all antibodies in serum  Produced slowly upon primary exposure to an antigen  Produced rapidly during secondary or subsequent exposure, becoming the major antibody present  The principal humoral component of immunological me ...
Yoga for Cancer - Healing Through Yoga
Yoga for Cancer - Healing Through Yoga

An Introduction to Artificial Immune Systems
An Introduction to Artificial Immune Systems

... The size of the detector set does not necessarily increase with the number of strings being protected The detection probability increases exponentially with the number of ...
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immuno chapter 4 [5-12

... nucleic acids, as well as simple small chemical groups and parts of macromolecules  Broad specificity of B cells enables antibodies to recognize diverse microbes and toxins in their native form o Most T cells see only peptides, and only when they are displayed on APCs bound to membrane proteins enc ...
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Therapeutic Proteins

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BiTEs - CARE

... -addition of the endodomain of CD28 co-stimulatory molecule increases in vivo persistence by activating the PI3K-AKT-mTOR pathway leading to proliferation and protein synthesis. ...
PHYSIOLOGY OF THE NEWBORN
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... • The cells of innate immunity interact with one another and with other host cells during the initiation and effector stages of innate and adaptive immune responses ...
Diapositiva 1
Diapositiva 1

... History of human immunodeficiency virus (HIV) infection or chronic hepatitis B or C. Patients who had prior chemotherapy, targeted small molecule therapy, or radiation therapy within 4 weeks prior to study Day 1 or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to a p ...
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... • The cells of innate immunity interact with one another and with other host cells during the initiation and effector stages of innate and adaptive immune responses ...
Paraneoplastic Cerebellar Degeneration
Paraneoplastic Cerebellar Degeneration

Scientific background  Activation of the immune system 
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... Humans as well as all other species are dependent on efficient defense systems against  invading microorganisms for their survival. Research on the immune system has  consequently been of great importance for our understanding of how we can defend  ourselves against microorganisms to survive their t ...
Chapter 21 The Lymphatic System
Chapter 21 The Lymphatic System

... Complement System • Complement (C) proteins in blood that must be activated by pathogens • Pathways of complement activation: C3 split into C3a and C3b – classical pathway • requires antibody; specific immunity ...
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Cancer immunotherapy



Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.
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